The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors

NK cells are an attractive target for cancer immunotherapy due to their potent antitumor activity. The main advantage of using NK cells as cytotoxic effectors over T cells is a reduced risk of graft versus host disease. At present, several variants of NK-cell-based therapies are undergoing clinical...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rodion A. Velichinskii, Maria A. Streltsova, Sofya A. Kust, Alexander M. Sapozhnikov, Elena I. Kovalenko
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	NK cells hematological tumors NK cell immunotherapy genetic modification Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/83ca3865322b4cc78ed811691b3cbe1c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:83ca3865322b4cc78ed811691b3cbe1c
record_format	dspace
spelling	oai:doaj.org-article:83ca3865322b4cc78ed811691b3cbe1c2021-11-11T16:51:26ZThe Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors10.3390/ijms2221113851422-00671661-6596https://doaj.org/article/83ca3865322b4cc78ed811691b3cbe1c2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11385https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067NK cells are an attractive target for cancer immunotherapy due to their potent antitumor activity. The main advantage of using NK cells as cytotoxic effectors over T cells is a reduced risk of graft versus host disease. At present, several variants of NK-cell-based therapies are undergoing clinical trials and show considerable effectiveness for hematological tumors. In these types of cancers, the immune cells themselves often undergo malignant transformation, which determines the features of the disease. In contrast, the current use of NK cells as therapeutic agents for the treatment of solid tumors is much less promising. Most studies are at the stage of preclinical investigation, but few progress to clinical trials. Low efficiency of NK cell migration and functional activity in the tumor environment are currently considered the major barriers to NK cell anti-tumor therapies. Various therapeutic combinations, genetic engineering methods, alternative sources for obtaining NK cells, and other techniques are aiming at the development of promising NK cell anticancer therapies, regardless of tumorigenesis. In this review, we compare the role of NK cells in the pathogenesis of hematological and solid tumors and discuss current prospects of NK-cell-based therapy for hematological and solid tumors.Rodion A. VelichinskiiMaria A. StreltsovaSofya A. KustAlexander M. SapozhnikovElena I. KovalenkoMDPI AGarticleNK cellshematological tumorshematological tumorsNK cell immunotherapygenetic modificationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11385, p 11385 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NK cells hematological tumors hematological tumors NK cell immunotherapy genetic modification Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	NK cells hematological tumors hematological tumors NK cell immunotherapy genetic modification Biology (General) QH301-705.5 Chemistry QD1-999 Rodion A. Velichinskii Maria A. Streltsova Sofya A. Kust Alexander M. Sapozhnikov Elena I. Kovalenko The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors
description	NK cells are an attractive target for cancer immunotherapy due to their potent antitumor activity. The main advantage of using NK cells as cytotoxic effectors over T cells is a reduced risk of graft versus host disease. At present, several variants of NK-cell-based therapies are undergoing clinical trials and show considerable effectiveness for hematological tumors. In these types of cancers, the immune cells themselves often undergo malignant transformation, which determines the features of the disease. In contrast, the current use of NK cells as therapeutic agents for the treatment of solid tumors is much less promising. Most studies are at the stage of preclinical investigation, but few progress to clinical trials. Low efficiency of NK cell migration and functional activity in the tumor environment are currently considered the major barriers to NK cell anti-tumor therapies. Various therapeutic combinations, genetic engineering methods, alternative sources for obtaining NK cells, and other techniques are aiming at the development of promising NK cell anticancer therapies, regardless of tumorigenesis. In this review, we compare the role of NK cells in the pathogenesis of hematological and solid tumors and discuss current prospects of NK-cell-based therapy for hematological and solid tumors.
format	article
author	Rodion A. Velichinskii Maria A. Streltsova Sofya A. Kust Alexander M. Sapozhnikov Elena I. Kovalenko
author_facet	Rodion A. Velichinskii Maria A. Streltsova Sofya A. Kust Alexander M. Sapozhnikov Elena I. Kovalenko
author_sort	Rodion A. Velichinskii
title	The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors
title_short	The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors
title_full	The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors
title_fullStr	The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors
title_full_unstemmed	The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors
title_sort	biological role and therapeutic potential of nk cells in hematological and solid tumors
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/83ca3865322b4cc78ed811691b3cbe1c
work_keys_str_mv	AT rodionavelichinskii thebiologicalroleandtherapeuticpotentialofnkcellsinhematologicalandsolidtumors AT mariaastreltsova thebiologicalroleandtherapeuticpotentialofnkcellsinhematologicalandsolidtumors AT sofyaakust thebiologicalroleandtherapeuticpotentialofnkcellsinhematologicalandsolidtumors AT alexandermsapozhnikov thebiologicalroleandtherapeuticpotentialofnkcellsinhematologicalandsolidtumors AT elenaikovalenko thebiologicalroleandtherapeuticpotentialofnkcellsinhematologicalandsolidtumors AT rodionavelichinskii biologicalroleandtherapeuticpotentialofnkcellsinhematologicalandsolidtumors AT mariaastreltsova biologicalroleandtherapeuticpotentialofnkcellsinhematologicalandsolidtumors AT sofyaakust biologicalroleandtherapeuticpotentialofnkcellsinhematologicalandsolidtumors AT alexandermsapozhnikov biologicalroleandtherapeuticpotentialofnkcellsinhematologicalandsolidtumors AT elenaikovalenko biologicalroleandtherapeuticpotentialofnkcellsinhematologicalandsolidtumors
_version_	1718432249367494656

The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors

Ejemplares similares