Real-world gait speed estimation, frailty and handgrip strength: a cohort-based study

Abstract Gait speed is a reliable outcome measure across multiple diagnoses, recognized as the 6th vital sign. The focus of the present study was on assessment of gait speed in long-term real-life settings with the aim to: (1) demonstrate feasibility in large cohort studies, using data recorded with...

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Autores principales:	Abolfazl Soltani, Nazanin Abolhassani, Pedro Marques-Vidal, Kamiar Aminian, Peter Vollenweider, Anisoara Paraschiv-Ionescu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83cb6f71751140c6ae31b58b52bf6921
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spelling	oai:doaj.org-article:83cb6f71751140c6ae31b58b52bf69212021-12-02T18:48:09ZReal-world gait speed estimation, frailty and handgrip strength: a cohort-based study10.1038/s41598-021-98359-02045-2322https://doaj.org/article/83cb6f71751140c6ae31b58b52bf69212021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98359-0https://doaj.org/toc/2045-2322Abstract Gait speed is a reliable outcome measure across multiple diagnoses, recognized as the 6th vital sign. The focus of the present study was on assessment of gait speed in long-term real-life settings with the aim to: (1) demonstrate feasibility in large cohort studies, using data recorded with a wrist-worn accelerometer device; (2) investigate whether the walking speed assessed in the real-world is consistent with expected trends, and associated with clinical scores such as frailty/handgrip strength. This cross-sectional study included n = 2809 participants (1508 women, 1301 men, [45–75] years old), monitored with a wrist-worn device for 13 consecutive days. Validated algorithms were used to detect the gait bouts and estimate speed. A set of metrics were derived from the statistical distribution of speed of gait bouts categorized by duration (short, medium, long). The estimated usual gait speed (1–1.6 m/s) appears consistent with normative values and expected trends with age, gender, BMI and physical activity levels. Speed metrics significantly improved detection of frailty: AUC increase from 0.763 (no speed metrics) to 0.798, 0.800 and 0.793 for the 95th percentile of individual’s gait speed for bout durations < 30, 30–120 and > 120 s, respectively (all p < 0.001). Similarly, speed metrics also improved the prediction of handgrip strength: AUC increase from 0.669 (no speed metrics) to 0.696, 0.696 and 0.691 for the 95th percentile of individual’s gait speed for bout durations < 30, 30–120 and > 120 s, respectively (all p < 0.001). Forward stepwise regression showed that the 95th percentile speed of gait bouts with medium duration (30–120 s) to be the best predictor for both conditions. The study provides evidence that real-world gait speed can be estimated using a wrist-worn wearable system, and can be used as reliable indicator of age-related functional decline.Abolfazl SoltaniNazanin AbolhassaniPedro Marques-VidalKamiar AminianPeter VollenweiderAnisoara Paraschiv-IonescuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abolfazl Soltani Nazanin Abolhassani Pedro Marques-Vidal Kamiar Aminian Peter Vollenweider Anisoara Paraschiv-Ionescu Real-world gait speed estimation, frailty and handgrip strength: a cohort-based study
description	Abstract Gait speed is a reliable outcome measure across multiple diagnoses, recognized as the 6th vital sign. The focus of the present study was on assessment of gait speed in long-term real-life settings with the aim to: (1) demonstrate feasibility in large cohort studies, using data recorded with a wrist-worn accelerometer device; (2) investigate whether the walking speed assessed in the real-world is consistent with expected trends, and associated with clinical scores such as frailty/handgrip strength. This cross-sectional study included n = 2809 participants (1508 women, 1301 men, [45–75] years old), monitored with a wrist-worn device for 13 consecutive days. Validated algorithms were used to detect the gait bouts and estimate speed. A set of metrics were derived from the statistical distribution of speed of gait bouts categorized by duration (short, medium, long). The estimated usual gait speed (1–1.6 m/s) appears consistent with normative values and expected trends with age, gender, BMI and physical activity levels. Speed metrics significantly improved detection of frailty: AUC increase from 0.763 (no speed metrics) to 0.798, 0.800 and 0.793 for the 95th percentile of individual’s gait speed for bout durations < 30, 30–120 and > 120 s, respectively (all p < 0.001). Similarly, speed metrics also improved the prediction of handgrip strength: AUC increase from 0.669 (no speed metrics) to 0.696, 0.696 and 0.691 for the 95th percentile of individual’s gait speed for bout durations < 30, 30–120 and > 120 s, respectively (all p < 0.001). Forward stepwise regression showed that the 95th percentile speed of gait bouts with medium duration (30–120 s) to be the best predictor for both conditions. The study provides evidence that real-world gait speed can be estimated using a wrist-worn wearable system, and can be used as reliable indicator of age-related functional decline.
format	article
author	Abolfazl Soltani Nazanin Abolhassani Pedro Marques-Vidal Kamiar Aminian Peter Vollenweider Anisoara Paraschiv-Ionescu
author_facet	Abolfazl Soltani Nazanin Abolhassani Pedro Marques-Vidal Kamiar Aminian Peter Vollenweider Anisoara Paraschiv-Ionescu
author_sort	Abolfazl Soltani
title	Real-world gait speed estimation, frailty and handgrip strength: a cohort-based study
title_short	Real-world gait speed estimation, frailty and handgrip strength: a cohort-based study
title_full	Real-world gait speed estimation, frailty and handgrip strength: a cohort-based study
title_fullStr	Real-world gait speed estimation, frailty and handgrip strength: a cohort-based study
title_full_unstemmed	Real-world gait speed estimation, frailty and handgrip strength: a cohort-based study
title_sort	real-world gait speed estimation, frailty and handgrip strength: a cohort-based study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/83cb6f71751140c6ae31b58b52bf6921
work_keys_str_mv	AT abolfazlsoltani realworldgaitspeedestimationfrailtyandhandgripstrengthacohortbasedstudy AT nazaninabolhassani realworldgaitspeedestimationfrailtyandhandgripstrengthacohortbasedstudy AT pedromarquesvidal realworldgaitspeedestimationfrailtyandhandgripstrengthacohortbasedstudy AT kamiaraminian realworldgaitspeedestimationfrailtyandhandgripstrengthacohortbasedstudy AT petervollenweider realworldgaitspeedestimationfrailtyandhandgripstrengthacohortbasedstudy AT anisoaraparaschivionescu realworldgaitspeedestimationfrailtyandhandgripstrengthacohortbasedstudy
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Real-world gait speed estimation, frailty and handgrip strength: a cohort-based study

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