Prevalence of celiac disease in low and high risk population in Asia–Pacific region: a systematic review and meta-analysis

Abstract This systematic review and meta-analysis study was conducted to estimate the pooled prevalence of CD in low and high risk groups in this region. Following keywords were searched in the Medline, PubMed, Scopus, Web of Science and Cochrane database according to the MeSH terms; celiac disease,...

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Autores principales:	Sara Ashtari, Hadis Najafimehr, Mohamad Amin Pourhoseingholi, Kamran Rostami, Hamid Asadzadeh-Aghdaei, Mohammad Rostami-Nejad, Mostafa Rezaei Tavirani, Meysam Olfatifar, Govind K. Makharia, Mohammad Reza Zali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83cd2d4b8eac4f91b07dcb04c0af8d77
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spelling	oai:doaj.org-article:83cd2d4b8eac4f91b07dcb04c0af8d772021-12-02T10:48:31ZPrevalence of celiac disease in low and high risk population in Asia–Pacific region: a systematic review and meta-analysis10.1038/s41598-021-82023-82045-2322https://doaj.org/article/83cd2d4b8eac4f91b07dcb04c0af8d772021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82023-8https://doaj.org/toc/2045-2322Abstract This systematic review and meta-analysis study was conducted to estimate the pooled prevalence of CD in low and high risk groups in this region. Following keywords were searched in the Medline, PubMed, Scopus, Web of Science and Cochrane database according to the MeSH terms; celiac disease, prevalence, high risk population and Asian-Pacific region. Prevalence studies published from January 1991 to March 2018 were selected. Prevalence of CD with 95% confidence interval (CI) was calculated using STATA software, version 14. The pooled sero-prevalence of CD among low risk group in Asia–Pacific region was 1.2% (95% CI 0.8–1.7%) in 96,099 individuals based on positive anti-tissue transglutaminase (anti-t-TG Ab) and/or anti-endomysial antibodies (EMA). The pooled prevalence of biopsy proven CD in Asia–Pacific among high and low risk groups was 4.3% (95% CI 3.3–5.5%) and 0.61% (95% CI 0.4–0.8%) in 10,719 and 70,344 subjects, respectively. In addition, the pooled sero-prevalence and prevalence of CD in general population was significantly higher in children compared with adults and it was significantly greater in female vs. male (P < 0.05). Our results suggest high risk individuals of CD are key group that should be specifically targeted for prevention and control measures, and screening may prove to have an optimal cost–benefit ratio.Sara AshtariHadis NajafimehrMohamad Amin PourhoseingholiKamran RostamiHamid Asadzadeh-AghdaeiMohammad Rostami-NejadMostafa Rezaei TaviraniMeysam OlfatifarGovind K. MakhariaMohammad Reza ZaliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sara Ashtari Hadis Najafimehr Mohamad Amin Pourhoseingholi Kamran Rostami Hamid Asadzadeh-Aghdaei Mohammad Rostami-Nejad Mostafa Rezaei Tavirani Meysam Olfatifar Govind K. Makharia Mohammad Reza Zali Prevalence of celiac disease in low and high risk population in Asia–Pacific region: a systematic review and meta-analysis
description	Abstract This systematic review and meta-analysis study was conducted to estimate the pooled prevalence of CD in low and high risk groups in this region. Following keywords were searched in the Medline, PubMed, Scopus, Web of Science and Cochrane database according to the MeSH terms; celiac disease, prevalence, high risk population and Asian-Pacific region. Prevalence studies published from January 1991 to March 2018 were selected. Prevalence of CD with 95% confidence interval (CI) was calculated using STATA software, version 14. The pooled sero-prevalence of CD among low risk group in Asia–Pacific region was 1.2% (95% CI 0.8–1.7%) in 96,099 individuals based on positive anti-tissue transglutaminase (anti-t-TG Ab) and/or anti-endomysial antibodies (EMA). The pooled prevalence of biopsy proven CD in Asia–Pacific among high and low risk groups was 4.3% (95% CI 3.3–5.5%) and 0.61% (95% CI 0.4–0.8%) in 10,719 and 70,344 subjects, respectively. In addition, the pooled sero-prevalence and prevalence of CD in general population was significantly higher in children compared with adults and it was significantly greater in female vs. male (P < 0.05). Our results suggest high risk individuals of CD are key group that should be specifically targeted for prevention and control measures, and screening may prove to have an optimal cost–benefit ratio.
format	article
author	Sara Ashtari Hadis Najafimehr Mohamad Amin Pourhoseingholi Kamran Rostami Hamid Asadzadeh-Aghdaei Mohammad Rostami-Nejad Mostafa Rezaei Tavirani Meysam Olfatifar Govind K. Makharia Mohammad Reza Zali
author_facet	Sara Ashtari Hadis Najafimehr Mohamad Amin Pourhoseingholi Kamran Rostami Hamid Asadzadeh-Aghdaei Mohammad Rostami-Nejad Mostafa Rezaei Tavirani Meysam Olfatifar Govind K. Makharia Mohammad Reza Zali
author_sort	Sara Ashtari
title	Prevalence of celiac disease in low and high risk population in Asia–Pacific region: a systematic review and meta-analysis
title_short	Prevalence of celiac disease in low and high risk population in Asia–Pacific region: a systematic review and meta-analysis
title_full	Prevalence of celiac disease in low and high risk population in Asia–Pacific region: a systematic review and meta-analysis
title_fullStr	Prevalence of celiac disease in low and high risk population in Asia–Pacific region: a systematic review and meta-analysis
title_full_unstemmed	Prevalence of celiac disease in low and high risk population in Asia–Pacific region: a systematic review and meta-analysis
title_sort	prevalence of celiac disease in low and high risk population in asia–pacific region: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/83cd2d4b8eac4f91b07dcb04c0af8d77
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Prevalence of celiac disease in low and high risk population in Asia–Pacific region: a systematic review and meta-analysis

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