Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

Min Li,1 Weiyue Zhang,2 Birong Wang,3 Yang Gao,1 Zifang Song,1 Qi Chang Zheng1 1Department of Hepatobiliary Surgery, Union Hospital, 2The First Clinic Institute, Tongji Medical College, Huazhong University of Science and Technology, 3Department of Breast and Thyroid Surgery, Puai Hospital, Wuhan, T...

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Autores principales:	Li M, Zhang W, Wang B, Gao Y, Song Z, Zheng QC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	targeted therapy hepatocellular carcinoma ligand drug delivery system nanoparticle Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/83cdef968cbc411081c9586f923e4b98
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spelling	oai:doaj.org-article:83cdef968cbc411081c9586f923e4b982021-12-02T04:53:02ZLigand-based targeted therapy: a novel strategy for hepatocellular carcinoma1178-2013https://doaj.org/article/83cdef968cbc411081c9586f923e4b982016-10-01T00:00:00Zhttps://www.dovepress.com/ligand-based-targeted-therapy-a-novel-strategy-for-hepatocellular-carc-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Min Li,1 Weiyue Zhang,2 Birong Wang,3 Yang Gao,1 Zifang Song,1 Qi Chang Zheng1 1Department of Hepatobiliary Surgery, Union Hospital, 2The First Clinic Institute, Tongji Medical College, Huazhong University of Science and Technology, 3Department of Breast and Thyroid Surgery, Puai Hospital, Wuhan, The People’s Republic of China Abstract: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with high morbidity and mortality worldwide. Chemotherapy is recommended to patients with intermediate or advanced stage cancer. However, the conventional chemotherapy yields low desired response rates due to multidrug resistance, fast clearance rate, nonspecific delivery, severe side effects, low drug concentration in cancer cells, and so on. Nanoparticle-mediated targeted drug delivery system can surmount the aforementioned obstacles through enhanced permeability and retention effect and active targeting as a novel approach of therapeutics for HCC in recent years. The active targeting is triggered by ligands on the delivery system, which recognize with and internalize into hepatoma cells with high specificity and efficiency. This review focuses on the latest targeted delivery systems for HCC and summarizes the ligands that can enhance the capacity of active targeting, to provide some insight into future research in nanomedicine for HCC. Keywords: targeted therapy, hepatocellular carcinoma, ligand, drug delivery system, nanoparticleLi MZhang WWang BGao YSong ZZheng QCDove Medical Pressarticletargeted therapyhepatocellular carcinomaliganddrug delivery systemnanoparticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 5645-5669 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	targeted therapy hepatocellular carcinoma ligand drug delivery system nanoparticle Medicine (General) R5-920
spellingShingle	targeted therapy hepatocellular carcinoma ligand drug delivery system nanoparticle Medicine (General) R5-920 Li M Zhang W Wang B Gao Y Song Z Zheng QC Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma
description	Min Li,1 Weiyue Zhang,2 Birong Wang,3 Yang Gao,1 Zifang Song,1 Qi Chang Zheng1 1Department of Hepatobiliary Surgery, Union Hospital, 2The First Clinic Institute, Tongji Medical College, Huazhong University of Science and Technology, 3Department of Breast and Thyroid Surgery, Puai Hospital, Wuhan, The People’s Republic of China Abstract: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with high morbidity and mortality worldwide. Chemotherapy is recommended to patients with intermediate or advanced stage cancer. However, the conventional chemotherapy yields low desired response rates due to multidrug resistance, fast clearance rate, nonspecific delivery, severe side effects, low drug concentration in cancer cells, and so on. Nanoparticle-mediated targeted drug delivery system can surmount the aforementioned obstacles through enhanced permeability and retention effect and active targeting as a novel approach of therapeutics for HCC in recent years. The active targeting is triggered by ligands on the delivery system, which recognize with and internalize into hepatoma cells with high specificity and efficiency. This review focuses on the latest targeted delivery systems for HCC and summarizes the ligands that can enhance the capacity of active targeting, to provide some insight into future research in nanomedicine for HCC. Keywords: targeted therapy, hepatocellular carcinoma, ligand, drug delivery system, nanoparticle
format	article
author	Li M Zhang W Wang B Gao Y Song Z Zheng QC
author_facet	Li M Zhang W Wang B Gao Y Song Z Zheng QC
author_sort	Li M
title	Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma
title_short	Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma
title_full	Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma
title_fullStr	Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma
title_full_unstemmed	Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma
title_sort	ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/83cdef968cbc411081c9586f923e4b98
work_keys_str_mv	AT lim ligandbasedtargetedtherapyanovelstrategyforhepatocellularcarcinoma AT zhangw ligandbasedtargetedtherapyanovelstrategyforhepatocellularcarcinoma AT wangb ligandbasedtargetedtherapyanovelstrategyforhepatocellularcarcinoma AT gaoy ligandbasedtargetedtherapyanovelstrategyforhepatocellularcarcinoma AT songz ligandbasedtargetedtherapyanovelstrategyforhepatocellularcarcinoma AT zhengqc ligandbasedtargetedtherapyanovelstrategyforhepatocellularcarcinoma
_version_	1718401018115391488

Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

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