The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health

East Asians (EAs) experience worse metabolic health outcomes compared to other ethnic groups at lower body mass indices; however, the potential role of the gut microbiota in contributing to these health disparities remains unknown. We conducted a multi-omic study of 46 lean and obese East Asian and...

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Autores principales:	Qi Yan Ang, Diana L Alba, Vaibhav Upadhyay, Jordan E Bisanz, Jingwei Cai, Ho Lim Lee, Eliseo Barajas, Grace Wei, Cecilia Noecker, Andrew D Patterson, Suneil K Koliwad, Peter J Turnbaugh
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	human gut microbiome ethnicity multi-omics metabolic syndrome obesity biogeography Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/83d0bc1c7af04b4c88d291ca551b57b2
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spelling	oai:doaj.org-article:83d0bc1c7af04b4c88d291ca551b57b22021-11-24T11:45:53ZThe East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health10.7554/eLife.703492050-084Xe70349https://doaj.org/article/83d0bc1c7af04b4c88d291ca551b57b22021-10-01T00:00:00Zhttps://elifesciences.org/articles/70349https://doaj.org/toc/2050-084XEast Asians (EAs) experience worse metabolic health outcomes compared to other ethnic groups at lower body mass indices; however, the potential role of the gut microbiota in contributing to these health disparities remains unknown. We conducted a multi-omic study of 46 lean and obese East Asian and White participants living in the San Francisco Bay Area, revealing marked differences between ethnic groups in bacterial richness and community structure. White individuals were enriched for the mucin-degrading Akkermansia muciniphila. East Asian subjects had increased levels of multiple bacterial phyla, fermentative pathways detected by metagenomics, and the short-chain fatty acid end-products acetate, propionate, and isobutyrate. Differences in the gut microbiota between the East Asian and White subjects could not be explained by dietary intake, were more pronounced in lean individuals, and were associated with current geographical location. Microbiome transplantations into germ-free mice demonstrated stable diet- and host genotype-independent differences between the gut microbiotas of East Asian and White individuals that differentially impact host body composition. Taken together, our findings add to the growing body of literature describing microbiome variations between ethnicities and provide a starting point for defining the mechanisms through which the microbiome may shape disparate health outcomes in East Asians.Qi Yan AngDiana L AlbaVaibhav UpadhyayJordan E BisanzJingwei CaiHo Lim LeeEliseo BarajasGrace WeiCecilia NoeckerAndrew D PattersonSuneil K KoliwadPeter J TurnbaugheLife Sciences Publications Ltdarticlehuman gut microbiomeethnicitymulti-omicsmetabolic syndromeobesitybiogeographyMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human gut microbiome ethnicity multi-omics metabolic syndrome obesity biogeography Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	human gut microbiome ethnicity multi-omics metabolic syndrome obesity biogeography Medicine R Science Q Biology (General) QH301-705.5 Qi Yan Ang Diana L Alba Vaibhav Upadhyay Jordan E Bisanz Jingwei Cai Ho Lim Lee Eliseo Barajas Grace Wei Cecilia Noecker Andrew D Patterson Suneil K Koliwad Peter J Turnbaugh The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health
description	East Asians (EAs) experience worse metabolic health outcomes compared to other ethnic groups at lower body mass indices; however, the potential role of the gut microbiota in contributing to these health disparities remains unknown. We conducted a multi-omic study of 46 lean and obese East Asian and White participants living in the San Francisco Bay Area, revealing marked differences between ethnic groups in bacterial richness and community structure. White individuals were enriched for the mucin-degrading Akkermansia muciniphila. East Asian subjects had increased levels of multiple bacterial phyla, fermentative pathways detected by metagenomics, and the short-chain fatty acid end-products acetate, propionate, and isobutyrate. Differences in the gut microbiota between the East Asian and White subjects could not be explained by dietary intake, were more pronounced in lean individuals, and were associated with current geographical location. Microbiome transplantations into germ-free mice demonstrated stable diet- and host genotype-independent differences between the gut microbiotas of East Asian and White individuals that differentially impact host body composition. Taken together, our findings add to the growing body of literature describing microbiome variations between ethnicities and provide a starting point for defining the mechanisms through which the microbiome may shape disparate health outcomes in East Asians.
format	article
author	Qi Yan Ang Diana L Alba Vaibhav Upadhyay Jordan E Bisanz Jingwei Cai Ho Lim Lee Eliseo Barajas Grace Wei Cecilia Noecker Andrew D Patterson Suneil K Koliwad Peter J Turnbaugh
author_facet	Qi Yan Ang Diana L Alba Vaibhav Upadhyay Jordan E Bisanz Jingwei Cai Ho Lim Lee Eliseo Barajas Grace Wei Cecilia Noecker Andrew D Patterson Suneil K Koliwad Peter J Turnbaugh
author_sort	Qi Yan Ang
title	The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health
title_short	The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health
title_full	The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health
title_fullStr	The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health
title_full_unstemmed	The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health
title_sort	east asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/83d0bc1c7af04b4c88d291ca551b57b2
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The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health

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