Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder

Yichen Huang,1,* Xing Shi,2,* Zhiyong Li,1,* Yang Shen,1,* Xinxin Shi,1 Liying Wang,3 Gaofei Li,3 Ye Yuan,2 Jixiang Wang,4 Yongchao Zhang,4 Lei Zhao,4 Meng Zhang,4 Yu Kang,2 Ying Liang1 1National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental He...

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Autores principales: Huang YC, Shi X, Li ZY, Shen Y, Shi XX, Wang LY, Li GF, Yuan Y, Wang JX, Zhang YC, Zhao L, Zhang M, Kang Y, Liang Y
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Publicado: Dove Medical Press 2018
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spelling oai:doaj.org-article:83d1f3c6f057478eae9fc4578bc759052021-12-02T12:20:17ZPossible association of Firmicutes in the gut microbiota of patients with major depressive disorder1178-2021https://doaj.org/article/83d1f3c6f057478eae9fc4578bc759052018-12-01T00:00:00Zhttps://www.dovepress.com/possible-association-of-firmicutes-in-the-gut-microbiota-of-patients-w-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yichen Huang,1,* Xing Shi,2,* Zhiyong Li,1,* Yang Shen,1,* Xinxin Shi,1 Liying Wang,3 Gaofei Li,3 Ye Yuan,2 Jixiang Wang,4 Yongchao Zhang,4 Lei Zhao,4 Meng Zhang,4 Yu Kang,2 Ying Liang1 1National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China; 2CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; 3Department of Psychiatry, Beijing Hospital of Chinese Traditional and Western Medicine, Beijing, China; 4Beijing Gene Tangram Technology Co. Ltd, Beijing, China *These authors contributed equally to this work Background: Gut microbiota can affect human behavior and mood in many ways. Several studies have shown that patients with depression were also accompanied with gut microbiota disorder, in which Firmicutes are related to the protective function of intestinal barrier. In this study, we explore the changes and effects of Firmicutes in the patients with major depressive disorder (MDD). Method: We recruited 54 subjects, including 27 patients with MDD. Fecal samples were collected for identification by 16S rRNA sequencing and bioinformatics analysis. Results: The study shows that the alpha diversity indices of MDD patients are lower than those of the healthy controls. Firmicutes is the most significantly decreased phylum in the MDD samples. There are totally 13 taxonomic biomarkers with P-value <0.01 from Firmicutes. There are differences in 17 KEGG pathways between the two groups. Conclusion: This study found that there is a significant disorder of gut microbiota in the patients with depression, in which the Firmicutes decreased significantly. Defects of the Firmicutes may lead to the depression in short-chain fatty acids, which could account for the physiological basis of low-level inflammation of depression.Limitations: This is a cross-sectional study and the sample size is comparatively small. Though several diet-related factors were controlled in the study, there is no quantified assessment of it. Keywords: gut microbiota, brain–gut axis, depression, Firmicutes, short-chain fatty acidsHuang YCShi XLi ZYShen YShi XXWang LYLi GFYuan YWang JXZhang YCZhao LZhang MKang YLiang YDove Medical PressarticleGut microbiotaBrain-gut axisDepressionFirmicutesShort chain fatty acidsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3329-3337 (2018)
institution DOAJ
collection DOAJ
language EN
topic Gut microbiota
Brain-gut axis
Depression
Firmicutes
Short chain fatty acids
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Gut microbiota
Brain-gut axis
Depression
Firmicutes
Short chain fatty acids
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Huang YC
Shi X
Li ZY
Shen Y
Shi XX
Wang LY
Li GF
Yuan Y
Wang JX
Zhang YC
Zhao L
Zhang M
Kang Y
Liang Y
Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder
description Yichen Huang,1,* Xing Shi,2,* Zhiyong Li,1,* Yang Shen,1,* Xinxin Shi,1 Liying Wang,3 Gaofei Li,3 Ye Yuan,2 Jixiang Wang,4 Yongchao Zhang,4 Lei Zhao,4 Meng Zhang,4 Yu Kang,2 Ying Liang1 1National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China; 2CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; 3Department of Psychiatry, Beijing Hospital of Chinese Traditional and Western Medicine, Beijing, China; 4Beijing Gene Tangram Technology Co. Ltd, Beijing, China *These authors contributed equally to this work Background: Gut microbiota can affect human behavior and mood in many ways. Several studies have shown that patients with depression were also accompanied with gut microbiota disorder, in which Firmicutes are related to the protective function of intestinal barrier. In this study, we explore the changes and effects of Firmicutes in the patients with major depressive disorder (MDD). Method: We recruited 54 subjects, including 27 patients with MDD. Fecal samples were collected for identification by 16S rRNA sequencing and bioinformatics analysis. Results: The study shows that the alpha diversity indices of MDD patients are lower than those of the healthy controls. Firmicutes is the most significantly decreased phylum in the MDD samples. There are totally 13 taxonomic biomarkers with P-value <0.01 from Firmicutes. There are differences in 17 KEGG pathways between the two groups. Conclusion: This study found that there is a significant disorder of gut microbiota in the patients with depression, in which the Firmicutes decreased significantly. Defects of the Firmicutes may lead to the depression in short-chain fatty acids, which could account for the physiological basis of low-level inflammation of depression.Limitations: This is a cross-sectional study and the sample size is comparatively small. Though several diet-related factors were controlled in the study, there is no quantified assessment of it. Keywords: gut microbiota, brain–gut axis, depression, Firmicutes, short-chain fatty acids
format article
author Huang YC
Shi X
Li ZY
Shen Y
Shi XX
Wang LY
Li GF
Yuan Y
Wang JX
Zhang YC
Zhao L
Zhang M
Kang Y
Liang Y
author_facet Huang YC
Shi X
Li ZY
Shen Y
Shi XX
Wang LY
Li GF
Yuan Y
Wang JX
Zhang YC
Zhao L
Zhang M
Kang Y
Liang Y
author_sort Huang YC
title Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder
title_short Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder
title_full Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder
title_fullStr Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder
title_full_unstemmed Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder
title_sort possible association of firmicutes in the gut microbiota of patients with major depressive disorder
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/83d1f3c6f057478eae9fc4578bc75905
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