STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis

Autosomal dominant hyper-immunoglobulin E syndrome (AD-HIES) is associated with mutations in STAT3, and clinical manifestations include skeletal deformities. Here, the authors show that inactivation of STAT3 in osteoblast induces AD-HIES-like skeletal defects by impairing osteogenesis, and show that...

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Autores principales:	Siru Zhou, Qinggang Dai, Xiangru Huang, Anting Jin, Yiling Yang, Xinyi Gong, Hongyuan Xu, Xin Gao, Lingyong Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83d48e76096c44808ad628e730bb12b5
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spelling	oai:doaj.org-article:83d48e76096c44808ad628e730bb12b52021-11-28T12:35:04ZSTAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis10.1038/s41467-021-27273-w2041-1723https://doaj.org/article/83d48e76096c44808ad628e730bb12b52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27273-whttps://doaj.org/toc/2041-1723Autosomal dominant hyper-immunoglobulin E syndrome (AD-HIES) is associated with mutations in STAT3, and clinical manifestations include skeletal deformities. Here, the authors show that inactivation of STAT3 in osteoblast induces AD-HIES-like skeletal defects by impairing osteogenesis, and show that pharmacological STAT3 activation rescues the phenotype.Siru ZhouQinggang DaiXiangru HuangAnting JinYiling YangXinyi GongHongyuan XuXin GaoLingyong JiangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siru Zhou Qinggang Dai Xiangru Huang Anting Jin Yiling Yang Xinyi Gong Hongyuan Xu Xin Gao Lingyong Jiang STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
description	Autosomal dominant hyper-immunoglobulin E syndrome (AD-HIES) is associated with mutations in STAT3, and clinical manifestations include skeletal deformities. Here, the authors show that inactivation of STAT3 in osteoblast induces AD-HIES-like skeletal defects by impairing osteogenesis, and show that pharmacological STAT3 activation rescues the phenotype.
format	article
author	Siru Zhou Qinggang Dai Xiangru Huang Anting Jin Yiling Yang Xinyi Gong Hongyuan Xu Xin Gao Lingyong Jiang
author_facet	Siru Zhou Qinggang Dai Xiangru Huang Anting Jin Yiling Yang Xinyi Gong Hongyuan Xu Xin Gao Lingyong Jiang
author_sort	Siru Zhou
title	STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
title_short	STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
title_full	STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
title_fullStr	STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
title_full_unstemmed	STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
title_sort	stat3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/83d48e76096c44808ad628e730bb12b5
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STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis

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