Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

Semaphorin-plexin interactions regulate various developmental processes in Drosophila but the structural basis of these signaling events is unclear. Here, the authors present crystal structures of all Drosophila class 1 and 2 semaphorins, and elucidate determinants for their plexin binding specifici...

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Autores principales:	Daniel Rozbesky, Ross A. Robinson, Vitul Jain, Max Renner, Tomas Malinauskas, Karl Harlos, Christian Siebold, E. Yvonne Jones
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83d5a240211049d4bd6a9086ef4edd87
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spelling	oai:doaj.org-article:83d5a240211049d4bd6a9086ef4edd872021-12-02T16:58:01ZDiversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning10.1038/s41467-019-11683-y2041-1723https://doaj.org/article/83d5a240211049d4bd6a9086ef4edd872019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11683-yhttps://doaj.org/toc/2041-1723Semaphorin-plexin interactions regulate various developmental processes in Drosophila but the structural basis of these signaling events is unclear. Here, the authors present crystal structures of all Drosophila class 1 and 2 semaphorins, and elucidate determinants for their plexin binding specificities.Daniel RozbeskyRoss A. RobinsonVitul JainMax RennerTomas MalinauskasKarl HarlosChristian SieboldE. Yvonne JonesNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Rozbesky Ross A. Robinson Vitul Jain Max Renner Tomas Malinauskas Karl Harlos Christian Siebold E. Yvonne Jones Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
description	Semaphorin-plexin interactions regulate various developmental processes in Drosophila but the structural basis of these signaling events is unclear. Here, the authors present crystal structures of all Drosophila class 1 and 2 semaphorins, and elucidate determinants for their plexin binding specificities.
format	article
author	Daniel Rozbesky Ross A. Robinson Vitul Jain Max Renner Tomas Malinauskas Karl Harlos Christian Siebold E. Yvonne Jones
author_facet	Daniel Rozbesky Ross A. Robinson Vitul Jain Max Renner Tomas Malinauskas Karl Harlos Christian Siebold E. Yvonne Jones
author_sort	Daniel Rozbesky
title	Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
title_short	Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
title_full	Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
title_fullStr	Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
title_full_unstemmed	Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
title_sort	diversity of oligomerization in drosophila semaphorins suggests a mechanism of functional fine-tuning
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/83d5a240211049d4bd6a9086ef4edd87
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Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

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