Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

PCNA is essential for DNA replication and cellular proliferation. Here, the authors reveal that PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation via regulation of Okazaki fragment maturation and chromatin assembly.

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Autores principales: Tanay Thakar, Wendy Leung, Claudia M. Nicolae, Kristen E. Clements, Binghui Shen, Anja-Katrin Bielinsky, George-Lucian Moldovan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/83d73c42ce554d03b39eb16def8e823b
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spelling oai:doaj.org-article:83d73c42ce554d03b39eb16def8e823b2021-12-02T17:31:42ZUbiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly10.1038/s41467-020-16096-w2041-1723https://doaj.org/article/83d73c42ce554d03b39eb16def8e823b2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16096-whttps://doaj.org/toc/2041-1723PCNA is essential for DNA replication and cellular proliferation. Here, the authors reveal that PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation via regulation of Okazaki fragment maturation and chromatin assembly.Tanay ThakarWendy LeungClaudia M. NicolaeKristen E. ClementsBinghui ShenAnja-Katrin BielinskyGeorge-Lucian MoldovanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tanay Thakar
Wendy Leung
Claudia M. Nicolae
Kristen E. Clements
Binghui Shen
Anja-Katrin Bielinsky
George-Lucian Moldovan
Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly
description PCNA is essential for DNA replication and cellular proliferation. Here, the authors reveal that PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation via regulation of Okazaki fragment maturation and chromatin assembly.
format article
author Tanay Thakar
Wendy Leung
Claudia M. Nicolae
Kristen E. Clements
Binghui Shen
Anja-Katrin Bielinsky
George-Lucian Moldovan
author_facet Tanay Thakar
Wendy Leung
Claudia M. Nicolae
Kristen E. Clements
Binghui Shen
Anja-Katrin Bielinsky
George-Lucian Moldovan
author_sort Tanay Thakar
title Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly
title_short Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly
title_full Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly
title_fullStr Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly
title_full_unstemmed Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly
title_sort ubiquitinated-pcna protects replication forks from dna2-mediated degradation by regulating okazaki fragment maturation and chromatin assembly
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/83d73c42ce554d03b39eb16def8e823b
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AT wendyleung ubiquitinatedpcnaprotectsreplicationforksfromdna2mediateddegradationbyregulatingokazakifragmentmaturationandchromatinassembly
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