A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents
Yongting Yuan,1,* Hong Xie,1,2,* Lili Sun,1 Bangxuan Wang,1 Li Zhang,1 Hui Han,1 Rongying Yao,1 Yehuan Sun,2 Lianguo Fu1 1Department of Child and Adolescent Health, School of Public Health, Bengbu Medical College, Bengbu, People’s Republic of China; 2Department of Epidemiology and Health S...
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Dove Medical Press
2020
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oai:doaj.org-article:83da8257f1804938b3c3d6d5afd5e6d52021-12-02T12:08:17ZA Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents1178-7007https://doaj.org/article/83da8257f1804938b3c3d6d5afd5e6d52020-05-01T00:00:00Zhttps://www.dovepress.com/a-novel-indicator-of-childrenrsquos-lipid-accumulation-product-associa-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Yongting Yuan,1,* Hong Xie,1,2,* Lili Sun,1 Bangxuan Wang,1 Li Zhang,1 Hui Han,1 Rongying Yao,1 Yehuan Sun,2 Lianguo Fu1 1Department of Child and Adolescent Health, School of Public Health, Bengbu Medical College, Bengbu, People’s Republic of China; 2Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lianguo FuDepartment of Child and Adolescents Health, School of Public Health, Bengbu Medical College, 2600 East Sea Avenue, Bengbu 233030, Anhui, People’s Republic of ChinaTel +8613195529639Fax +86-5523175215Email lianguofu@163.comYehuan SunDepartment of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Meishan Road, Hefei 230032, Anhui, People’s Republic of ChinaEmail yhsun_ahmu_edu@yeah.netBackground: Diabetes is one of the most prevalent noncommunicable diseases worldwide. Children’s lipid accumulation product (CLAP) is a novel indicator to show children’s lipid accumulation and is effectively associated with metabolic syndrome among children and adolescents. The aim of the present study was to explore an association between CLAP and impaired fasting glucose (IFG) in Chinese children and adolescents.Methods: A total of 683 children and adolescents aged 8– 15 years were recruited using the stratified cluster sampling method in this cross-sectional study and were measured for body height, weight, waist circumference (WC), abdominal skinfold thickness (AST), triglycerides (TG), fasting plasma glucose, dietary behaviors and physical activities. A logistic regression model and receiver operating characteristic (ROC) curve were used to compare the effects of CLAP for predicting IFG.Results: The prevalence of IFG in children and adolescents was 13.8%: 16.9% in boys and 10.1% in girls (P< 0.05). The CLAP, height, weight, WC, AST, waist-to-height ratio (WHtR), and TG among boys with IFG were significantly higher than those among boys without IFG (P< 0.05). The area under the ROC curve of CLAP for predicting IFG (0.637 (0.562– 0.712)) was higher than those of WC, WHtR, AST, and TG. The cutoff point of P75 CLAP was the optimal value to predict IFG among boys, and the OR (95% CI) was 2.48 (1.40– 4.42) and area under the ROC curve was 0.595 (0.513– 0.676).Conclusion: The CLAP was a novel indicator associated with IFG in Chinese boys, and it performed better than WC, WHtR, AST and TG.Keywords: impaired fasting glucose, children’s lipid accumulation product, children and adolescentsYuan YXie HSun LWang BZhang LHan HYao RSun YFu LDove Medical Pressarticleimpaired fasting glucosechildren lipid accumulation productchildren and adolescentsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1653-1660 (2020) |
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EN |
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impaired fasting glucose children lipid accumulation product children and adolescents Specialties of internal medicine RC581-951 |
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impaired fasting glucose children lipid accumulation product children and adolescents Specialties of internal medicine RC581-951 Yuan Y Xie H Sun L Wang B Zhang L Han H Yao R Sun Y Fu L A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents |
| description |
Yongting Yuan,1,* Hong Xie,1,2,* Lili Sun,1 Bangxuan Wang,1 Li Zhang,1 Hui Han,1 Rongying Yao,1 Yehuan Sun,2 Lianguo Fu1 1Department of Child and Adolescent Health, School of Public Health, Bengbu Medical College, Bengbu, People’s Republic of China; 2Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lianguo FuDepartment of Child and Adolescents Health, School of Public Health, Bengbu Medical College, 2600 East Sea Avenue, Bengbu 233030, Anhui, People’s Republic of ChinaTel +8613195529639Fax +86-5523175215Email lianguofu@163.comYehuan SunDepartment of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Meishan Road, Hefei 230032, Anhui, People’s Republic of ChinaEmail yhsun_ahmu_edu@yeah.netBackground: Diabetes is one of the most prevalent noncommunicable diseases worldwide. Children’s lipid accumulation product (CLAP) is a novel indicator to show children’s lipid accumulation and is effectively associated with metabolic syndrome among children and adolescents. The aim of the present study was to explore an association between CLAP and impaired fasting glucose (IFG) in Chinese children and adolescents.Methods: A total of 683 children and adolescents aged 8– 15 years were recruited using the stratified cluster sampling method in this cross-sectional study and were measured for body height, weight, waist circumference (WC), abdominal skinfold thickness (AST), triglycerides (TG), fasting plasma glucose, dietary behaviors and physical activities. A logistic regression model and receiver operating characteristic (ROC) curve were used to compare the effects of CLAP for predicting IFG.Results: The prevalence of IFG in children and adolescents was 13.8%: 16.9% in boys and 10.1% in girls (P< 0.05). The CLAP, height, weight, WC, AST, waist-to-height ratio (WHtR), and TG among boys with IFG were significantly higher than those among boys without IFG (P< 0.05). The area under the ROC curve of CLAP for predicting IFG (0.637 (0.562– 0.712)) was higher than those of WC, WHtR, AST, and TG. The cutoff point of P75 CLAP was the optimal value to predict IFG among boys, and the OR (95% CI) was 2.48 (1.40– 4.42) and area under the ROC curve was 0.595 (0.513– 0.676).Conclusion: The CLAP was a novel indicator associated with IFG in Chinese boys, and it performed better than WC, WHtR, AST and TG.Keywords: impaired fasting glucose, children’s lipid accumulation product, children and adolescents |
| format |
article |
| author |
Yuan Y Xie H Sun L Wang B Zhang L Han H Yao R Sun Y Fu L |
| author_facet |
Yuan Y Xie H Sun L Wang B Zhang L Han H Yao R Sun Y Fu L |
| author_sort |
Yuan Y |
| title |
A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents |
| title_short |
A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents |
| title_full |
A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents |
| title_fullStr |
A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents |
| title_full_unstemmed |
A Novel Indicator of Children’s Lipid Accumulation Product Associated with Impaired Fasting Glucose in Chinese Children and Adolescents |
| title_sort |
novel indicator of children’s lipid accumulation product associated with impaired fasting glucose in chinese children and adolescents |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/83da8257f1804938b3c3d6d5afd5e6d5 |
| work_keys_str_mv |
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