Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase

O-linked β-N-acetyl glucosamine (O-GlcNAc) is an important protein modification that is hydrolyzed by O-GlcNAcase (OGA). Here the authors give insights into OGA substrate recognition by presenting four human OGA structures complexed with glycopeptide substrates containing a single O-GlcNAc modificat...

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Autores principales:	Baobin Li, Hao Li, Chia-Wei Hu, Jiaoyang Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83dd0423da5d4c818b6d5f0359d95d24
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spelling	oai:doaj.org-article:83dd0423da5d4c818b6d5f0359d95d242021-12-02T17:06:12ZStructural insights into the substrate binding adaptability and specificity of human O-GlcNAcase10.1038/s41467-017-00865-12041-1723https://doaj.org/article/83dd0423da5d4c818b6d5f0359d95d242017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00865-1https://doaj.org/toc/2041-1723O-linked β-N-acetyl glucosamine (O-GlcNAc) is an important protein modification that is hydrolyzed by O-GlcNAcase (OGA). Here the authors give insights into OGA substrate recognition by presenting four human OGA structures complexed with glycopeptide substrates containing a single O-GlcNAc modification on either a serine or threonine.Baobin LiHao LiChia-Wei HuJiaoyang JiangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baobin Li Hao Li Chia-Wei Hu Jiaoyang Jiang Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase
description	O-linked β-N-acetyl glucosamine (O-GlcNAc) is an important protein modification that is hydrolyzed by O-GlcNAcase (OGA). Here the authors give insights into OGA substrate recognition by presenting four human OGA structures complexed with glycopeptide substrates containing a single O-GlcNAc modification on either a serine or threonine.
format	article
author	Baobin Li Hao Li Chia-Wei Hu Jiaoyang Jiang
author_facet	Baobin Li Hao Li Chia-Wei Hu Jiaoyang Jiang
author_sort	Baobin Li
title	Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase
title_short	Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase
title_full	Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase
title_fullStr	Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase
title_full_unstemmed	Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase
title_sort	structural insights into the substrate binding adaptability and specificity of human o-glcnacase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/83dd0423da5d4c818b6d5f0359d95d24
work_keys_str_mv	AT baobinli structuralinsightsintothesubstratebindingadaptabilityandspecificityofhumanoglcnacase AT haoli structuralinsightsintothesubstratebindingadaptabilityandspecificityofhumanoglcnacase AT chiaweihu structuralinsightsintothesubstratebindingadaptabilityandspecificityofhumanoglcnacase AT jiaoyangjiang structuralinsightsintothesubstratebindingadaptabilityandspecificityofhumanoglcnacase
_version_	1718381684936671232

Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase

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