Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

The cytokines IL-1β and IL-6 mediate the systemic acute phase response (APR). Here, the authors provide evidence that these cytokines lead to both synergistic and antagonistic gene expression during APR; synergistic induction occurs by assisted loading of STAT3 on chromatin by NF-κB.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ido Goldstein, Ville Paakinaho, Songjoon Baek, Myong-Hee Sung, Gordon L. Hager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83dd9a360d454efdb91e2a2f30859fb8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:83dd9a360d454efdb91e2a2f30859fb8
record_format	dspace
spelling	oai:doaj.org-article:83dd9a360d454efdb91e2a2f30859fb82021-12-02T14:42:08ZSynergistic gene expression during the acute phase response is characterized by transcription factor assisted loading10.1038/s41467-017-02055-52041-1723https://doaj.org/article/83dd9a360d454efdb91e2a2f30859fb82017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02055-5https://doaj.org/toc/2041-1723The cytokines IL-1β and IL-6 mediate the systemic acute phase response (APR). Here, the authors provide evidence that these cytokines lead to both synergistic and antagonistic gene expression during APR; synergistic induction occurs by assisted loading of STAT3 on chromatin by NF-κB.Ido GoldsteinVille PaakinahoSongjoon BaekMyong-Hee SungGordon L. HagerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ido Goldstein Ville Paakinaho Songjoon Baek Myong-Hee Sung Gordon L. Hager Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading
description	The cytokines IL-1β and IL-6 mediate the systemic acute phase response (APR). Here, the authors provide evidence that these cytokines lead to both synergistic and antagonistic gene expression during APR; synergistic induction occurs by assisted loading of STAT3 on chromatin by NF-κB.
format	article
author	Ido Goldstein Ville Paakinaho Songjoon Baek Myong-Hee Sung Gordon L. Hager
author_facet	Ido Goldstein Ville Paakinaho Songjoon Baek Myong-Hee Sung Gordon L. Hager
author_sort	Ido Goldstein
title	Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading
title_short	Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading
title_full	Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading
title_fullStr	Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading
title_full_unstemmed	Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading
title_sort	synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/83dd9a360d454efdb91e2a2f30859fb8
work_keys_str_mv	AT idogoldstein synergisticgeneexpressionduringtheacutephaseresponseischaracterizedbytranscriptionfactorassistedloading AT villepaakinaho synergisticgeneexpressionduringtheacutephaseresponseischaracterizedbytranscriptionfactorassistedloading AT songjoonbaek synergisticgeneexpressionduringtheacutephaseresponseischaracterizedbytranscriptionfactorassistedloading AT myongheesung synergisticgeneexpressionduringtheacutephaseresponseischaracterizedbytranscriptionfactorassistedloading AT gordonlhager synergisticgeneexpressionduringtheacutephaseresponseischaracterizedbytranscriptionfactorassistedloading
_version_	1718389762156396544

Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

Ejemplares similares