The Association between Sarcoidosis and Ischemic Heart Disease—A Healthcare Analysis of a Large Israeli Population

(1) Background: Inflammation plays a pivotal role in atherosclerosis, and the association between chronic inflammatory states and ischemic heart disease (IHD) has been shown in several rheumatic diseases. Persistent inflammation might also be a risk factor for IHD in sarcoidosis patients. (2) Method...

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Autores principales:	Tal Gonen, Daphna Katz-Talmor, Howard Amital, Doron Comaneshter, Arnon D. Cohen, Shmuel Tiosano
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sarcoidosis ischemic heart disease comorbidities Medicine R
Acceso en línea:	https://doaj.org/article/83ddf8c3f9d74625bf8be63e4d2e4040
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spelling	oai:doaj.org-article:83ddf8c3f9d74625bf8be63e4d2e40402021-11-11T17:41:37ZThe Association between Sarcoidosis and Ischemic Heart Disease—A Healthcare Analysis of a Large Israeli Population10.3390/jcm102150672077-0383https://doaj.org/article/83ddf8c3f9d74625bf8be63e4d2e40402021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5067https://doaj.org/toc/2077-0383(1) Background: Inflammation plays a pivotal role in atherosclerosis, and the association between chronic inflammatory states and ischemic heart disease (IHD) has been shown in several rheumatic diseases. Persistent inflammation might also be a risk factor for IHD in sarcoidosis patients. (2) Methods: Demographic and clinical data of 3750 sarcoidosis patients and 18,139 age- and sex-matched controls were retrieved from the database of Clalit Health Services, Israel’s largest healthcare organization. Variables associated with IHD were assessed by a logistic regression model. To assess for variables that were related to increased risk of all-cause mortality, the Cox proportional hazards method was used, and a log-rank test was performed for survival analysis. (3) Results: Both groups were composed of 64% females with a median age of 56 years. An association between sarcoidosis and IHD was demonstrated by a multivariate analysis (adjusted odds ratio (OR) 1.5; 95% confidence interval (CI) 1.36–1.66). Long-term follow-up revealed increased mortality among sarcoidosis patients: 561 (15%) deaths compared to 1636 (9%) deaths among controls (<i>p</i> < 0.001). Survival analysis demonstrated that sarcoidosis patients were also at increased risk for all-cause mortality compared to controls (multivariate model, adjusted HR 1.93; 95% CI 1.76–2.13).Tal GonenDaphna Katz-TalmorHoward AmitalDoron ComaneshterArnon D. CohenShmuel TiosanoMDPI AGarticlesarcoidosisischemic heart diseasecomorbiditiesMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5067, p 5067 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcoidosis ischemic heart disease comorbidities Medicine R
spellingShingle	sarcoidosis ischemic heart disease comorbidities Medicine R Tal Gonen Daphna Katz-Talmor Howard Amital Doron Comaneshter Arnon D. Cohen Shmuel Tiosano The Association between Sarcoidosis and Ischemic Heart Disease—A Healthcare Analysis of a Large Israeli Population
description	(1) Background: Inflammation plays a pivotal role in atherosclerosis, and the association between chronic inflammatory states and ischemic heart disease (IHD) has been shown in several rheumatic diseases. Persistent inflammation might also be a risk factor for IHD in sarcoidosis patients. (2) Methods: Demographic and clinical data of 3750 sarcoidosis patients and 18,139 age- and sex-matched controls were retrieved from the database of Clalit Health Services, Israel’s largest healthcare organization. Variables associated with IHD were assessed by a logistic regression model. To assess for variables that were related to increased risk of all-cause mortality, the Cox proportional hazards method was used, and a log-rank test was performed for survival analysis. (3) Results: Both groups were composed of 64% females with a median age of 56 years. An association between sarcoidosis and IHD was demonstrated by a multivariate analysis (adjusted odds ratio (OR) 1.5; 95% confidence interval (CI) 1.36–1.66). Long-term follow-up revealed increased mortality among sarcoidosis patients: 561 (15%) deaths compared to 1636 (9%) deaths among controls (<i>p</i> < 0.001). Survival analysis demonstrated that sarcoidosis patients were also at increased risk for all-cause mortality compared to controls (multivariate model, adjusted HR 1.93; 95% CI 1.76–2.13).
format	article
author	Tal Gonen Daphna Katz-Talmor Howard Amital Doron Comaneshter Arnon D. Cohen Shmuel Tiosano
author_facet	Tal Gonen Daphna Katz-Talmor Howard Amital Doron Comaneshter Arnon D. Cohen Shmuel Tiosano
author_sort	Tal Gonen
title	The Association between Sarcoidosis and Ischemic Heart Disease—A Healthcare Analysis of a Large Israeli Population
title_short	The Association between Sarcoidosis and Ischemic Heart Disease—A Healthcare Analysis of a Large Israeli Population
title_full	The Association between Sarcoidosis and Ischemic Heart Disease—A Healthcare Analysis of a Large Israeli Population
title_fullStr	The Association between Sarcoidosis and Ischemic Heart Disease—A Healthcare Analysis of a Large Israeli Population
title_full_unstemmed	The Association between Sarcoidosis and Ischemic Heart Disease—A Healthcare Analysis of a Large Israeli Population
title_sort	association between sarcoidosis and ischemic heart disease—a healthcare analysis of a large israeli population
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/83ddf8c3f9d74625bf8be63e4d2e4040
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The Association between Sarcoidosis and Ischemic Heart Disease—A Healthcare Analysis of a Large Israeli Population

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