Status epilepticus in patients with genetic (idiopathic) generalized epilepsy

Magdalena Bosak,1 Dominika Pawełczak,2 Agnieszka Słowik11Department of Neurology, Jagiellonian University Medical College, Krakow, Poland; 2Department of Neurology, Jagiellonian University Medical College, Krakow, PolandAim of the study: Genetic (idiopathic) generalized epilepsies (GGEs) account for...

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Autores principales:	Bosak M, Pawełczak D, Słowik A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	absence status epilepticus myoclonic status epilepticus genetic generalized epilepsy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/83dfd9e1f3944a10808b667fabd22b5d
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spelling	oai:doaj.org-article:83dfd9e1f3944a10808b667fabd22b5d2021-12-02T06:43:15ZStatus epilepticus in patients with genetic (idiopathic) generalized epilepsy1178-2021https://doaj.org/article/83dfd9e1f3944a10808b667fabd22b5d2019-06-01T00:00:00Zhttps://www.dovepress.com/status-epilepticus-in-patients-with-genetic-idiopathic-generalized-epi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Magdalena Bosak,1 Dominika Pawełczak,2 Agnieszka Słowik11Department of Neurology, Jagiellonian University Medical College, Krakow, Poland; 2Department of Neurology, Jagiellonian University Medical College, Krakow, PolandAim of the study: Genetic (idiopathic) generalized epilepsies (GGEs) account for nearly one-third of all epilepsies. The frequency of status epilepticus (SE) in patients with GGEs has been poorly studied. Therefore, this study aimed to evaluate the frequency of different forms of SE in a cohort of patients with GGEs.Materials and methods: Among 153 patients with GGEs treated at the university epilepsy clinic in the period between 1998 and 2018, those with SE were retrospectively identified.Results: Absence SE was diagnosed in 8 patients (13 episodes), while myoclonic SE was found in 2 patients (2 episodes). No cases of tonic–clonic SE were detected in the study cohort. Most SE episodes were found to be provoked by ill-advised antiepileptic drugs or changes in drug regimen. In all the subjects, SE was stopped by intravenous administration of diazepam and/or valproate. Long-term outcome of epilepsy was good, with most patients (70%) being seizure-free.Conclusion: Status epilepticus is not a rare phenomenon in patients with genetic generalized epilepsies, with absence SE being the most common type. Most cases of SE are provoked by ill-advised AEDs or changes in drug regimen. Status epilepticus in GGEs can be easily treated with benozdiazepines and/or valproate. Status epilepticus in GGEs can be easily treated with benozdiazepines and/or valproate.Keywords: absence status epilepticus, myoclonic status epilepticus, genetic generalized epilepsyBosak MPawełczak DSłowik ADove Medical Pressarticleabsence status epilepticusmyoclonic status epilepticusgenetic generalized epilepsyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1585-1592 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	absence status epilepticus myoclonic status epilepticus genetic generalized epilepsy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	absence status epilepticus myoclonic status epilepticus genetic generalized epilepsy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Bosak M Pawełczak D Słowik A Status epilepticus in patients with genetic (idiopathic) generalized epilepsy
description	Magdalena Bosak,1 Dominika Pawełczak,2 Agnieszka Słowik11Department of Neurology, Jagiellonian University Medical College, Krakow, Poland; 2Department of Neurology, Jagiellonian University Medical College, Krakow, PolandAim of the study: Genetic (idiopathic) generalized epilepsies (GGEs) account for nearly one-third of all epilepsies. The frequency of status epilepticus (SE) in patients with GGEs has been poorly studied. Therefore, this study aimed to evaluate the frequency of different forms of SE in a cohort of patients with GGEs.Materials and methods: Among 153 patients with GGEs treated at the university epilepsy clinic in the period between 1998 and 2018, those with SE were retrospectively identified.Results: Absence SE was diagnosed in 8 patients (13 episodes), while myoclonic SE was found in 2 patients (2 episodes). No cases of tonic–clonic SE were detected in the study cohort. Most SE episodes were found to be provoked by ill-advised antiepileptic drugs or changes in drug regimen. In all the subjects, SE was stopped by intravenous administration of diazepam and/or valproate. Long-term outcome of epilepsy was good, with most patients (70%) being seizure-free.Conclusion: Status epilepticus is not a rare phenomenon in patients with genetic generalized epilepsies, with absence SE being the most common type. Most cases of SE are provoked by ill-advised AEDs or changes in drug regimen. Status epilepticus in GGEs can be easily treated with benozdiazepines and/or valproate. Status epilepticus in GGEs can be easily treated with benozdiazepines and/or valproate.Keywords: absence status epilepticus, myoclonic status epilepticus, genetic generalized epilepsy
format	article
author	Bosak M Pawełczak D Słowik A
author_facet	Bosak M Pawełczak D Słowik A
author_sort	Bosak M
title	Status epilepticus in patients with genetic (idiopathic) generalized epilepsy
title_short	Status epilepticus in patients with genetic (idiopathic) generalized epilepsy
title_full	Status epilepticus in patients with genetic (idiopathic) generalized epilepsy
title_fullStr	Status epilepticus in patients with genetic (idiopathic) generalized epilepsy
title_full_unstemmed	Status epilepticus in patients with genetic (idiopathic) generalized epilepsy
title_sort	status epilepticus in patients with genetic (idiopathic) generalized epilepsy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/83dfd9e1f3944a10808b667fabd22b5d
work_keys_str_mv	AT bosakm statusepilepticusinpatientswithgeneticidiopathicgeneralizedepilepsy AT pawełczakd statusepilepticusinpatientswithgeneticidiopathicgeneralizedepilepsy AT słowika statusepilepticusinpatientswithgeneticidiopathicgeneralizedepilepsy
_version_	1718399762007326720

Status epilepticus in patients with genetic (idiopathic) generalized epilepsy

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