Programmed Death-Ligand 1 Expression in Breast Cancer Patients: Clinicopathological Associations from a Single-Institution Study

Nehad M Ayoub,1 Mona Fares,1 Raya Marji,2 Samir M Al Bashir,2 Rami J Yaghan3 1Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology (JUST), Irbid, 22110, Jordan; 2Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science a...

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Autores principales:	Ayoub NM, Fares M, Marji R, Al Bashir SM, Yaghan RJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	breast cancer pd-l1 immunohistochemistry clinicopathologic prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/83e1a3366e854e76a196dee39bd6d8d2
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spelling	oai:doaj.org-article:83e1a3366e854e76a196dee39bd6d8d22021-12-02T18:25:51ZProgrammed Death-Ligand 1 Expression in Breast Cancer Patients: Clinicopathological Associations from a Single-Institution Study1179-1314https://doaj.org/article/83e1a3366e854e76a196dee39bd6d8d22021-11-01T00:00:00Zhttps://www.dovepress.com/programmed-death-ligand-1-expression-in-breast-cancer-patients-clinico-peer-reviewed-fulltext-article-BCTThttps://doaj.org/toc/1179-1314Nehad M Ayoub,1 Mona Fares,1 Raya Marji,2 Samir M Al Bashir,2 Rami J Yaghan3 1Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology (JUST), Irbid, 22110, Jordan; 2Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan; 3Department of Surgery, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, BahrainCorrespondence: Nehad M AyoubDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology (JUST), Irbid, 22110, JordanTel +962-2-7201000 Ext. 23809Fax +962-2-7095123Email nmayoub@just.edu.joPurpose: Tumor expression of programmed death-ligand 1 (PD-L1) is associated with evasion of immune response in several types of malignancies and such expression may render patients eligible for PD-L1 inhibitors. The use of immune checkpoint blockade therapy has been recently approved for the treatment of breast cancer. However, PD-L1 expression data are lacking among Jordanian breast cancer patients. In this study, the tumor PD-L1 expression was characterized in breast cancer patients to assess their eligibility for immune checkpoint blockade therapy. The study also aimed to explore the association between tumoral PD-L1 expression and the clinicopathologic characteristics and the prognostic factors in patients with breast cancer.Patients and Methods: Tissue samples were available from 153 female patients with primary invasive breast cancer. Immunohistochemistry was performed on paraffin-embedded tumor sections that were stained with a PD-L1 antibody. Expression of tumor PD-L1 was correlated with demographics, clinicopathologic characteristics, and prognosis.Results: The mean age at diagnosis was 54.2± 12.8 years (median 52, interquartile range 45– 65). The percentage of PD-L1-positive tumors was 26.1%. PD-L1 expression on tumor cells significantly and positively correlated with tumor size (rho=0.174, p=0.032). PD-L1 positivity was significantly associated with the grade of carcinoma (p=0.001), HER2-positivity (p=0.015), and lymphovascular invasion (p=0.036). PD-L1 intensity was significantly associated with tumor stage (p=0.046). No significant associations were observed for the PD-L1 expression status or intensity with patient menopausal status, hormone receptor expression, and molecular subtypes. PD-L1 expression significantly correlated with a worse prognosis of breast cancer patients at the time of diagnosis (rho=0.230, p=0.005).Conclusion: Tumor PD-L1 expression was associated with advanced clinicopathologic features and worse prognosis in this cohort of Jordanian breast cancer patients. Future studies are needed to better understand the impact of PD-L1 blockade therapy on treatment outcomes in eligible breast cancer patients in Jordan.Keywords: breast cancer, PD-L1, immunohistochemistry, clinicopathologic, prognosisAyoub NMFares MMarji RAl Bashir SMYaghan RJDove Medical Pressarticlebreast cancerpd-l1immunohistochemistryclinicopathologicprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 13, Pp 603-615 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer pd-l1 immunohistochemistry clinicopathologic prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer pd-l1 immunohistochemistry clinicopathologic prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ayoub NM Fares M Marji R Al Bashir SM Yaghan RJ Programmed Death-Ligand 1 Expression in Breast Cancer Patients: Clinicopathological Associations from a Single-Institution Study
description	Nehad M Ayoub,1 Mona Fares,1 Raya Marji,2 Samir M Al Bashir,2 Rami J Yaghan3 1Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology (JUST), Irbid, 22110, Jordan; 2Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan; 3Department of Surgery, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, BahrainCorrespondence: Nehad M AyoubDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology (JUST), Irbid, 22110, JordanTel +962-2-7201000 Ext. 23809Fax +962-2-7095123Email nmayoub@just.edu.joPurpose: Tumor expression of programmed death-ligand 1 (PD-L1) is associated with evasion of immune response in several types of malignancies and such expression may render patients eligible for PD-L1 inhibitors. The use of immune checkpoint blockade therapy has been recently approved for the treatment of breast cancer. However, PD-L1 expression data are lacking among Jordanian breast cancer patients. In this study, the tumor PD-L1 expression was characterized in breast cancer patients to assess their eligibility for immune checkpoint blockade therapy. The study also aimed to explore the association between tumoral PD-L1 expression and the clinicopathologic characteristics and the prognostic factors in patients with breast cancer.Patients and Methods: Tissue samples were available from 153 female patients with primary invasive breast cancer. Immunohistochemistry was performed on paraffin-embedded tumor sections that were stained with a PD-L1 antibody. Expression of tumor PD-L1 was correlated with demographics, clinicopathologic characteristics, and prognosis.Results: The mean age at diagnosis was 54.2± 12.8 years (median 52, interquartile range 45– 65). The percentage of PD-L1-positive tumors was 26.1%. PD-L1 expression on tumor cells significantly and positively correlated with tumor size (rho=0.174, p=0.032). PD-L1 positivity was significantly associated with the grade of carcinoma (p=0.001), HER2-positivity (p=0.015), and lymphovascular invasion (p=0.036). PD-L1 intensity was significantly associated with tumor stage (p=0.046). No significant associations were observed for the PD-L1 expression status or intensity with patient menopausal status, hormone receptor expression, and molecular subtypes. PD-L1 expression significantly correlated with a worse prognosis of breast cancer patients at the time of diagnosis (rho=0.230, p=0.005).Conclusion: Tumor PD-L1 expression was associated with advanced clinicopathologic features and worse prognosis in this cohort of Jordanian breast cancer patients. Future studies are needed to better understand the impact of PD-L1 blockade therapy on treatment outcomes in eligible breast cancer patients in Jordan.Keywords: breast cancer, PD-L1, immunohistochemistry, clinicopathologic, prognosis
format	article
author	Ayoub NM Fares M Marji R Al Bashir SM Yaghan RJ
author_facet	Ayoub NM Fares M Marji R Al Bashir SM Yaghan RJ
author_sort	Ayoub NM
title	Programmed Death-Ligand 1 Expression in Breast Cancer Patients: Clinicopathological Associations from a Single-Institution Study
title_short	Programmed Death-Ligand 1 Expression in Breast Cancer Patients: Clinicopathological Associations from a Single-Institution Study
title_full	Programmed Death-Ligand 1 Expression in Breast Cancer Patients: Clinicopathological Associations from a Single-Institution Study
title_fullStr	Programmed Death-Ligand 1 Expression in Breast Cancer Patients: Clinicopathological Associations from a Single-Institution Study
title_full_unstemmed	Programmed Death-Ligand 1 Expression in Breast Cancer Patients: Clinicopathological Associations from a Single-Institution Study
title_sort	programmed death-ligand 1 expression in breast cancer patients: clinicopathological associations from a single-institution study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/83e1a3366e854e76a196dee39bd6d8d2
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Programmed Death-Ligand 1 Expression in Breast Cancer Patients: Clinicopathological Associations from a Single-Institution Study

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