Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways

Schistosoma mansoniinfection has been linked with an increased risk of HIV acquisition in women. Here, the authors show that standard S. mansoniinfection treatment causes a reduction of HIV entry into cervical and blood CD4+ T cells, which is sustained for up to two months and is associated with de-...

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Autores principales:	Sergey Yegorov, Vineet Joag, Ronald M. Galiwango, Sara V. Good, Juliet Mpendo, Egbert Tannich, Andrea K. Boggild, Noah Kiwanuka, Bernard S. Bagaya, Rupert Kaul
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83e37d873e414aba9712be313021e6b2
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spelling	oai:doaj.org-article:83e37d873e414aba9712be313021e6b22021-12-02T14:39:58ZSchistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways10.1038/s41467-019-09900-92041-1723https://doaj.org/article/83e37d873e414aba9712be313021e6b22019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09900-9https://doaj.org/toc/2041-1723Schistosoma mansoniinfection has been linked with an increased risk of HIV acquisition in women. Here, the authors show that standard S. mansoniinfection treatment causes a reduction of HIV entry into cervical and blood CD4+ T cells, which is sustained for up to two months and is associated with de-repression of IFN-I signaling. Sergey YegorovVineet JoagRonald M. GaliwangoSara V. GoodJuliet MpendoEgbert TannichAndrea K. BoggildNoah KiwanukaBernard S. BagayaRupert KaulNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sergey Yegorov Vineet Joag Ronald M. Galiwango Sara V. Good Juliet Mpendo Egbert Tannich Andrea K. Boggild Noah Kiwanuka Bernard S. Bagaya Rupert Kaul Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways
description	Schistosoma mansoniinfection has been linked with an increased risk of HIV acquisition in women. Here, the authors show that standard S. mansoniinfection treatment causes a reduction of HIV entry into cervical and blood CD4+ T cells, which is sustained for up to two months and is associated with de-repression of IFN-I signaling.
format	article
author	Sergey Yegorov Vineet Joag Ronald M. Galiwango Sara V. Good Juliet Mpendo Egbert Tannich Andrea K. Boggild Noah Kiwanuka Bernard S. Bagaya Rupert Kaul
author_facet	Sergey Yegorov Vineet Joag Ronald M. Galiwango Sara V. Good Juliet Mpendo Egbert Tannich Andrea K. Boggild Noah Kiwanuka Bernard S. Bagaya Rupert Kaul
author_sort	Sergey Yegorov
title	Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways
title_short	Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways
title_full	Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways
title_fullStr	Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways
title_full_unstemmed	Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways
title_sort	schistosoma mansoni treatment reduces hiv entry into cervical cd4+ t cells and induces ifn-i pathways
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/83e37d873e414aba9712be313021e6b2
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Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways

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