Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion.

Concussion is associated with disrupted cerebral blood flow (CBF), although there appears to be substantial inter-individual variability in CBF response. At present, the mechanisms of variable CBF response remain incompletely understood, but one potential contributor is matrix metalloproteinase (MMP...

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Autores principales:	Nathan W Churchill, Alex P Di Battista, Shawn G Rhind, Doug Richards, Tom A Schweizer, Michael G Hutchison
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83e55dcef8ee4ae7a29d9c54684ef690
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spelling	oai:doaj.org-article:83e55dcef8ee4ae7a29d9c54684ef6902021-12-02T20:04:34ZCerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion.1932-620310.1371/journal.pone.0253134https://doaj.org/article/83e55dcef8ee4ae7a29d9c54684ef6902021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253134https://doaj.org/toc/1932-6203Concussion is associated with disrupted cerebral blood flow (CBF), although there appears to be substantial inter-individual variability in CBF response. At present, the mechanisms of variable CBF response remain incompletely understood, but one potential contributor is matrix metalloproteinase (MMP) expression. In more severe forms of acquired brain injury, MMP up-regulation contributes to CBF impairments via increased blood-brain barrier permeability. A similar relationship is hypothesized for concussion, where recently concussed individuals with higher MMP levels have lower CBF. To test this hypothesis, 35 concussed athletes were assessed longitudinally at early symptomatic injury (median: 5 days post-injury) and at medical clearance (median: 24 days post-injury), along with 71 athletic controls. For all athletes, plasma MMPs were measured and arterial spin labelling was used to measure CBF. Consistent with our hypothesis, higher concentrations of MMP-2 and MMP-3 were correlated with lower global CBF. The correlations between MMPs and global CBF were also significantly diminished for concussed athletes at medical clearance and for athletic controls. These results indicate an inverse relationship between plasma MMP levels and CBF that is specific to the symptomatic phase of concussion. Analyses of regional CBF further showed that correlations with MMP levels exhibited some spatial specificity, with greatest effects in occipital, parietal and temporal lobes. These findings provide new insights into the mechanisms of post-concussion cerebrovascular dysfunction.Nathan W ChurchillAlex P Di BattistaShawn G RhindDoug RichardsTom A SchweizerMichael G HutchisonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0253134 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nathan W Churchill Alex P Di Battista Shawn G Rhind Doug Richards Tom A Schweizer Michael G Hutchison Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion.
description	Concussion is associated with disrupted cerebral blood flow (CBF), although there appears to be substantial inter-individual variability in CBF response. At present, the mechanisms of variable CBF response remain incompletely understood, but one potential contributor is matrix metalloproteinase (MMP) expression. In more severe forms of acquired brain injury, MMP up-regulation contributes to CBF impairments via increased blood-brain barrier permeability. A similar relationship is hypothesized for concussion, where recently concussed individuals with higher MMP levels have lower CBF. To test this hypothesis, 35 concussed athletes were assessed longitudinally at early symptomatic injury (median: 5 days post-injury) and at medical clearance (median: 24 days post-injury), along with 71 athletic controls. For all athletes, plasma MMPs were measured and arterial spin labelling was used to measure CBF. Consistent with our hypothesis, higher concentrations of MMP-2 and MMP-3 were correlated with lower global CBF. The correlations between MMPs and global CBF were also significantly diminished for concussed athletes at medical clearance and for athletic controls. These results indicate an inverse relationship between plasma MMP levels and CBF that is specific to the symptomatic phase of concussion. Analyses of regional CBF further showed that correlations with MMP levels exhibited some spatial specificity, with greatest effects in occipital, parietal and temporal lobes. These findings provide new insights into the mechanisms of post-concussion cerebrovascular dysfunction.
format	article
author	Nathan W Churchill Alex P Di Battista Shawn G Rhind Doug Richards Tom A Schweizer Michael G Hutchison
author_facet	Nathan W Churchill Alex P Di Battista Shawn G Rhind Doug Richards Tom A Schweizer Michael G Hutchison
author_sort	Nathan W Churchill
title	Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion.
title_short	Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion.
title_full	Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion.
title_fullStr	Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion.
title_full_unstemmed	Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion.
title_sort	cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/83e55dcef8ee4ae7a29d9c54684ef690
work_keys_str_mv	AT nathanwchurchill cerebralbloodflowisassociatedwithmatrixmetalloproteinaselevelsduringtheearlysymptomaticphaseofconcussion AT alexpdibattista cerebralbloodflowisassociatedwithmatrixmetalloproteinaselevelsduringtheearlysymptomaticphaseofconcussion AT shawngrhind cerebralbloodflowisassociatedwithmatrixmetalloproteinaselevelsduringtheearlysymptomaticphaseofconcussion AT dougrichards cerebralbloodflowisassociatedwithmatrixmetalloproteinaselevelsduringtheearlysymptomaticphaseofconcussion AT tomaschweizer cerebralbloodflowisassociatedwithmatrixmetalloproteinaselevelsduringtheearlysymptomaticphaseofconcussion AT michaelghutchison cerebralbloodflowisassociatedwithmatrixmetalloproteinaselevelsduringtheearlysymptomaticphaseofconcussion
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Cerebral blood flow is associated with matrix metalloproteinase levels during the early symptomatic phase of concussion.

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