Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.

The fast-paced evolution of viruses enables them to quickly adapt to the organisms they infect by constantly exploring the potential functional landscape of the proteins encoded in their genomes. Geminiviruses, DNA viruses infecting plants and causing devastating crop diseases worldwide, produce a l...

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Autores principales:	Laura Medina-Puche, Anelise F Orílio, F Murilo Zerbini, Rosa Lozano-Durán
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/83e74eb90a2b44a8be2d4f8d77d51848
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spelling	oai:doaj.org-article:83e74eb90a2b44a8be2d4f8d77d518482021-12-02T20:00:03ZSmall but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.1553-73661553-737410.1371/journal.ppat.1009915https://doaj.org/article/83e74eb90a2b44a8be2d4f8d77d518482021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009915https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The fast-paced evolution of viruses enables them to quickly adapt to the organisms they infect by constantly exploring the potential functional landscape of the proteins encoded in their genomes. Geminiviruses, DNA viruses infecting plants and causing devastating crop diseases worldwide, produce a limited number of multifunctional proteins that mediate the manipulation of the cellular environment to the virus' advantage. Among the proteins produced by the members of this family, C4, the smallest one described to date, is emerging as a powerful viral effector with unexpected versatility. C4 is the only geminiviral protein consistently subjected to positive selection and displays a number of dynamic subcellular localizations, interacting partners, and functions, which can vary between viral species. In this review, we aim to summarize our current knowledge on this remarkable viral protein, encompassing the different aspects of its multilayered diversity, and discuss what it can teach us about geminivirus evolution, invasion requirements, and virulence strategies.Laura Medina-PucheAnelise F OrílioF Murilo ZerbiniRosa Lozano-DuránPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 10, p e1009915 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Laura Medina-Puche Anelise F Orílio F Murilo Zerbini Rosa Lozano-Durán Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.
description	The fast-paced evolution of viruses enables them to quickly adapt to the organisms they infect by constantly exploring the potential functional landscape of the proteins encoded in their genomes. Geminiviruses, DNA viruses infecting plants and causing devastating crop diseases worldwide, produce a limited number of multifunctional proteins that mediate the manipulation of the cellular environment to the virus' advantage. Among the proteins produced by the members of this family, C4, the smallest one described to date, is emerging as a powerful viral effector with unexpected versatility. C4 is the only geminiviral protein consistently subjected to positive selection and displays a number of dynamic subcellular localizations, interacting partners, and functions, which can vary between viral species. In this review, we aim to summarize our current knowledge on this remarkable viral protein, encompassing the different aspects of its multilayered diversity, and discuss what it can teach us about geminivirus evolution, invasion requirements, and virulence strategies.
format	article
author	Laura Medina-Puche Anelise F Orílio F Murilo Zerbini Rosa Lozano-Durán
author_facet	Laura Medina-Puche Anelise F Orílio F Murilo Zerbini Rosa Lozano-Durán
author_sort	Laura Medina-Puche
title	Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.
title_short	Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.
title_full	Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.
title_fullStr	Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.
title_full_unstemmed	Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.
title_sort	small but mighty: functional landscape of the versatile geminivirus-encoded c4 protein.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/83e74eb90a2b44a8be2d4f8d77d51848
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Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.

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