The incidence of myocardial infarction and stroke in head and neck cancer patients

Abstract Various treatment modalities are used for head and neck cancer (HNC). This study analyzed the incidence and risks of myocardial infarction (MI) and stroke by cancer site and treatment modality in 22,737 patients newly diagnosed with HNC registered in the Korean National Health Insurance Ser...

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Autores principales:	Hyun-Keun Kwon, Kyung-Do Han, Yong-Il Cheon, Sung-Chan Shin, Minhyung Lee, Eui-Suk Sung, Jin-Choon Lee, Byung-Joo Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83e77e773f3c40a8a02d4abcf04ce990
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spelling	oai:doaj.org-article:83e77e773f3c40a8a02d4abcf04ce9902021-12-02T14:21:59ZThe incidence of myocardial infarction and stroke in head and neck cancer patients10.1038/s41598-021-83665-42045-2322https://doaj.org/article/83e77e773f3c40a8a02d4abcf04ce9902021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83665-4https://doaj.org/toc/2045-2322Abstract Various treatment modalities are used for head and neck cancer (HNC). This study analyzed the incidence and risks of myocardial infarction (MI) and stroke by cancer site and treatment modality in 22,737 patients newly diagnosed with HNC registered in the Korean National Health Insurance Service database in 2007–2013. An additional 68,211 patients without HNC, stroke, or MI were identified as the control group. The risks for MI (hazard ratio [HR] = 1.38, 95% confidence interval [CI] 1.24–1.53), stroke (HR = 1.48, 95% CI 1.37–1.60), and mortality (HR = 5.30, 95% CI 5.14–5.47) were significantly higher in the HNC group. Analysis by cancer site showed the risk of MI and mortality was highest in hypopharynx cancer, while the risk of stroke was highest in nasopharynx and paranasal sinus cancer. Analysis by treatment modality showed the highest risks for MI (HR = 1.88, 95% CI 1.31–2.69) and mortality (HR = 2.95, 95% CI 2.75–3.17) in HNC patients receiving chemotherapy (CT) alone, while HNC patients receiving CT with surgery had the highest risk for stroke (HR = 1.81, 95% CI 1.14–2.88). Careful attention to MI and stroke risks in HNC patients is suggested, especially those who received both CT and radiotherapy.Hyun-Keun KwonKyung-Do HanYong-Il CheonSung-Chan ShinMinhyung LeeEui-Suk SungJin-Choon LeeByung-Joo LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyun-Keun Kwon Kyung-Do Han Yong-Il Cheon Sung-Chan Shin Minhyung Lee Eui-Suk Sung Jin-Choon Lee Byung-Joo Lee The incidence of myocardial infarction and stroke in head and neck cancer patients
description	Abstract Various treatment modalities are used for head and neck cancer (HNC). This study analyzed the incidence and risks of myocardial infarction (MI) and stroke by cancer site and treatment modality in 22,737 patients newly diagnosed with HNC registered in the Korean National Health Insurance Service database in 2007–2013. An additional 68,211 patients without HNC, stroke, or MI were identified as the control group. The risks for MI (hazard ratio [HR] = 1.38, 95% confidence interval [CI] 1.24–1.53), stroke (HR = 1.48, 95% CI 1.37–1.60), and mortality (HR = 5.30, 95% CI 5.14–5.47) were significantly higher in the HNC group. Analysis by cancer site showed the risk of MI and mortality was highest in hypopharynx cancer, while the risk of stroke was highest in nasopharynx and paranasal sinus cancer. Analysis by treatment modality showed the highest risks for MI (HR = 1.88, 95% CI 1.31–2.69) and mortality (HR = 2.95, 95% CI 2.75–3.17) in HNC patients receiving chemotherapy (CT) alone, while HNC patients receiving CT with surgery had the highest risk for stroke (HR = 1.81, 95% CI 1.14–2.88). Careful attention to MI and stroke risks in HNC patients is suggested, especially those who received both CT and radiotherapy.
format	article
author	Hyun-Keun Kwon Kyung-Do Han Yong-Il Cheon Sung-Chan Shin Minhyung Lee Eui-Suk Sung Jin-Choon Lee Byung-Joo Lee
author_facet	Hyun-Keun Kwon Kyung-Do Han Yong-Il Cheon Sung-Chan Shin Minhyung Lee Eui-Suk Sung Jin-Choon Lee Byung-Joo Lee
author_sort	Hyun-Keun Kwon
title	The incidence of myocardial infarction and stroke in head and neck cancer patients
title_short	The incidence of myocardial infarction and stroke in head and neck cancer patients
title_full	The incidence of myocardial infarction and stroke in head and neck cancer patients
title_fullStr	The incidence of myocardial infarction and stroke in head and neck cancer patients
title_full_unstemmed	The incidence of myocardial infarction and stroke in head and neck cancer patients
title_sort	incidence of myocardial infarction and stroke in head and neck cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/83e77e773f3c40a8a02d4abcf04ce990
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The incidence of myocardial infarction and stroke in head and neck cancer patients

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