Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications

Nima Pourhabibi Zarandi,1,* Guillermo Galdon,1,* Stanley Kogan,1,2 Anthony Atala,1,2 Hooman Sadri-Ardekani1,2 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Urology, Wake Forest School of Medicine, Winston-Salem, NC, USA *Thes...

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Autores principales:	Pourhabibi Zarandi N, Galdon G, Kogan S, Atala A, Sadri-Ardekani H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Testis Spermatogonial stem cell Tissue banking Cryopreservation Male infertility transplantation Cytology QH573-671
Acceso en línea:	https://doaj.org/article/83e823bad81a4b95ba6256d2324c1d9f
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spelling	oai:doaj.org-article:83e823bad81a4b95ba6256d2324c1d9f2021-12-02T01:15:54ZCryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications1178-6957https://doaj.org/article/83e823bad81a4b95ba6256d2324c1d9f2018-07-01T00:00:00Zhttps://www.dovepress.com/cryostorage-of-immature-and-mature-human-testis-tissue-to-preserve-spe-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Nima Pourhabibi Zarandi,1,* Guillermo Galdon,1,* Stanley Kogan,1,2 Anthony Atala,1,2 Hooman Sadri-Ardekani1,2 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Urology, Wake Forest School of Medicine, Winston-Salem, NC, USA *These authors contributed equally to this work Abstract: While the survival rate of children with cancer is increasing, preserving fertility for prepubertal boys is still a challenge. Although intracytoplasmic sperm injection (ICSI) using frozen sperms has revolutionized infertility treatment, it is not applicable for the patients who undergo chemotherapy before puberty since spermatogenesis has not begun. Therefore, preserving spermatogonial stem cells (SSCs) as an experimental option can be provided to prepubertal patients at a risk of damage or loss of their SSCs due to cancer treatments and developmental or genetic disorders. Using frozen SSCs in testicular tissue, successful SSC autotransplantation in mouse and nonhuman primates has shown a promising future for SSC-based cell therapy. Cryopreservation of testicular tissue containing SSCs is the first step to translate SSC-based cell therapy into clinical male infertility treatment, and in the investigation into SSCs, it is very important to evaluate their quantity and functionality during this process. This systematic review summarizes the published data on cryopreservation techniques in human testis tissue for potential utilization in future clinical applications. Keywords: testis, spermatogonial stem cell, tissue banking, cryopreservation, male infertility, transplantationPourhabibi Zarandi NGaldon GKogan SAtala ASadri-Ardekani HDove Medical PressarticleTestisSpermatogonial stem cellTissue bankingCryopreservationMale infertilitytransplantationCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol Volume 11, Pp 23-38 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Testis Spermatogonial stem cell Tissue banking Cryopreservation Male infertility transplantation Cytology QH573-671
spellingShingle	Testis Spermatogonial stem cell Tissue banking Cryopreservation Male infertility transplantation Cytology QH573-671 Pourhabibi Zarandi N Galdon G Kogan S Atala A Sadri-Ardekani H Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications
description	Nima Pourhabibi Zarandi,1,* Guillermo Galdon,1,* Stanley Kogan,1,2 Anthony Atala,1,2 Hooman Sadri-Ardekani1,2 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Urology, Wake Forest School of Medicine, Winston-Salem, NC, USA *These authors contributed equally to this work Abstract: While the survival rate of children with cancer is increasing, preserving fertility for prepubertal boys is still a challenge. Although intracytoplasmic sperm injection (ICSI) using frozen sperms has revolutionized infertility treatment, it is not applicable for the patients who undergo chemotherapy before puberty since spermatogenesis has not begun. Therefore, preserving spermatogonial stem cells (SSCs) as an experimental option can be provided to prepubertal patients at a risk of damage or loss of their SSCs due to cancer treatments and developmental or genetic disorders. Using frozen SSCs in testicular tissue, successful SSC autotransplantation in mouse and nonhuman primates has shown a promising future for SSC-based cell therapy. Cryopreservation of testicular tissue containing SSCs is the first step to translate SSC-based cell therapy into clinical male infertility treatment, and in the investigation into SSCs, it is very important to evaluate their quantity and functionality during this process. This systematic review summarizes the published data on cryopreservation techniques in human testis tissue for potential utilization in future clinical applications. Keywords: testis, spermatogonial stem cell, tissue banking, cryopreservation, male infertility, transplantation
format	article
author	Pourhabibi Zarandi N Galdon G Kogan S Atala A Sadri-Ardekani H
author_facet	Pourhabibi Zarandi N Galdon G Kogan S Atala A Sadri-Ardekani H
author_sort	Pourhabibi Zarandi N
title	Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications
title_short	Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications
title_full	Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications
title_fullStr	Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications
title_full_unstemmed	Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications
title_sort	cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (sscs): a systematic review of current experiences toward clinical applications
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/83e823bad81a4b95ba6256d2324c1d9f
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Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications

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