IMMUNOLOGICAL MONITORING OF SLOW DOWN OSTHEOGENESIS

Abstract. We have performed clinical and immunological investigation in the patients with trauma of face bones before and after stable mandibular ostheosynthesis. Blood samples for analysis were taken upon admission of the patient to clinics, and following treatment (3, 10, and 1-2 months). The pati...

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Autor principal:	O. V. Berdugina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immunological monitoring ostheogenesis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/83e8aabf881f4b73a93c9cee967ab8c3
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spelling	oai:doaj.org-article:83e8aabf881f4b73a93c9cee967ab8c32021-11-18T08:03:39ZIMMUNOLOGICAL MONITORING OF SLOW DOWN OSTHEOGENESIS1563-06252313-741X10.15789/1563-0625-2008-4-5-371-378https://doaj.org/article/83e8aabf881f4b73a93c9cee967ab8c32014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/194https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have performed clinical and immunological investigation in the patients with trauma of face bones before and after stable mandibular ostheosynthesis. Blood samples for analysis were taken upon admission of the patient to clinics, and following treatment (3, 10, and 1-2 months). The patients with initially retarded bone consolidation exhibited low levels of monocytes and lactoferrine before surgical treatment. It was shown that the consecutive stages of bone regeneration (inflammation, osteoblastic proliferation, collagenogenesis, and ossification) are accompanied by certain changes in immune parameters. In particular, we observed increased levels of IgМ, TNF, and activation of leucopoiesis after treatment. The results obtained allow us of discriminating some natural reactions of immune system in cases of normal and retarded bone consolidation. For each of these criteria, diagnostic sensitivity and informativity of tests are calculated, thus providing an opportunity to predict retarded consolidation in surgical treatment of the face bones. (Med. Immunol., 2007, vol. 10, N 4-5, pp 371-388).O. V. BerduginaSPb RAACIarticleimmunological monitoringostheogenesisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 371-378 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunological monitoring ostheogenesis Immunologic diseases. Allergy RC581-607
spellingShingle	immunological monitoring ostheogenesis Immunologic diseases. Allergy RC581-607 O. V. Berdugina IMMUNOLOGICAL MONITORING OF SLOW DOWN OSTHEOGENESIS
description	Abstract. We have performed clinical and immunological investigation in the patients with trauma of face bones before and after stable mandibular ostheosynthesis. Blood samples for analysis were taken upon admission of the patient to clinics, and following treatment (3, 10, and 1-2 months). The patients with initially retarded bone consolidation exhibited low levels of monocytes and lactoferrine before surgical treatment. It was shown that the consecutive stages of bone regeneration (inflammation, osteoblastic proliferation, collagenogenesis, and ossification) are accompanied by certain changes in immune parameters. In particular, we observed increased levels of IgМ, TNF, and activation of leucopoiesis after treatment. The results obtained allow us of discriminating some natural reactions of immune system in cases of normal and retarded bone consolidation. For each of these criteria, diagnostic sensitivity and informativity of tests are calculated, thus providing an opportunity to predict retarded consolidation in surgical treatment of the face bones. (Med. Immunol., 2007, vol. 10, N 4-5, pp 371-388).
format	article
author	O. V. Berdugina
author_facet	O. V. Berdugina
author_sort	O. V. Berdugina
title	IMMUNOLOGICAL MONITORING OF SLOW DOWN OSTHEOGENESIS
title_short	IMMUNOLOGICAL MONITORING OF SLOW DOWN OSTHEOGENESIS
title_full	IMMUNOLOGICAL MONITORING OF SLOW DOWN OSTHEOGENESIS
title_fullStr	IMMUNOLOGICAL MONITORING OF SLOW DOWN OSTHEOGENESIS
title_full_unstemmed	IMMUNOLOGICAL MONITORING OF SLOW DOWN OSTHEOGENESIS
title_sort	immunological monitoring of slow down ostheogenesis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/83e8aabf881f4b73a93c9cee967ab8c3
work_keys_str_mv	AT ovberdugina immunologicalmonitoringofslowdownostheogenesis
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IMMUNOLOGICAL MONITORING OF SLOW DOWN OSTHEOGENESIS

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