The spatial and temporal dynamics of rabies in China.

<h4>Background and objectives</h4>Recent years have seen a rapid increase in the number of rabies cases in China and an expansion in the geographic distribution of the virus. In spite of the seriousness of the outbreak and increasing number of fatalities, little is known about the phylog...

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Autores principales:	Jinning Yu, Hao Li, Qing Tang, Simon Rayner, Na Han, Zhenyang Guo, Haizhou Liu, James Adams, Wei Fang, Xiaoyan Tao, Shumei Wang, Guodong Liang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/83e8c7aefce54fd780a24964c55c8211
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spelling	oai:doaj.org-article:83e8c7aefce54fd780a24964c55c82112021-11-18T09:14:13ZThe spatial and temporal dynamics of rabies in China.1935-27271935-273510.1371/journal.pntd.0001640https://doaj.org/article/83e8c7aefce54fd780a24964c55c82112012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22563518/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background and objectives</h4>Recent years have seen a rapid increase in the number of rabies cases in China and an expansion in the geographic distribution of the virus. In spite of the seriousness of the outbreak and increasing number of fatalities, little is known about the phylogeography of the disease in China. In this study, we report an analysis of a set of Nucleocapsid sequences consisting of samples collected through the trial Chinese National Surveillance System as well as publicly available sequences. This sequence set represents the most comprehensive dataset from China to date, comprising 210 sequences (including 57 new samples) from 15 provinces and covering all epidemic regions. Using this dataset we investigated genetic diversity, patterns of distribution, and evolutionary history.<h4>Results</h4>Our analysis indicates that the rabies virus in China is primarily defined by two clades that exhibit distinct population subdivision and translocation patterns and that contributed to the epidemic in different ways. The younger clade originated around 1992 and has properties that closely match the observed spread of the recent epidemic. The older clade originated around 1960 and has a dispersion pattern that suggests it represents a strain associated with a previous outbreak that remained at low levels throughout the country and reemerged in the current epidemic.<h4>Conclusions</h4>Our findings provide new insight into factors associated with the recent epidemic and are relevant to determining an effective policy for controlling the virus.Jinning YuHao LiQing TangSimon RaynerNa HanZhenyang GuoHaizhou LiuJames AdamsWei FangXiaoyan TaoShumei WangGuodong LiangPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 6, Iss 5, p e1640 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jinning Yu Hao Li Qing Tang Simon Rayner Na Han Zhenyang Guo Haizhou Liu James Adams Wei Fang Xiaoyan Tao Shumei Wang Guodong Liang The spatial and temporal dynamics of rabies in China.
description	<h4>Background and objectives</h4>Recent years have seen a rapid increase in the number of rabies cases in China and an expansion in the geographic distribution of the virus. In spite of the seriousness of the outbreak and increasing number of fatalities, little is known about the phylogeography of the disease in China. In this study, we report an analysis of a set of Nucleocapsid sequences consisting of samples collected through the trial Chinese National Surveillance System as well as publicly available sequences. This sequence set represents the most comprehensive dataset from China to date, comprising 210 sequences (including 57 new samples) from 15 provinces and covering all epidemic regions. Using this dataset we investigated genetic diversity, patterns of distribution, and evolutionary history.<h4>Results</h4>Our analysis indicates that the rabies virus in China is primarily defined by two clades that exhibit distinct population subdivision and translocation patterns and that contributed to the epidemic in different ways. The younger clade originated around 1992 and has properties that closely match the observed spread of the recent epidemic. The older clade originated around 1960 and has a dispersion pattern that suggests it represents a strain associated with a previous outbreak that remained at low levels throughout the country and reemerged in the current epidemic.<h4>Conclusions</h4>Our findings provide new insight into factors associated with the recent epidemic and are relevant to determining an effective policy for controlling the virus.
format	article
author	Jinning Yu Hao Li Qing Tang Simon Rayner Na Han Zhenyang Guo Haizhou Liu James Adams Wei Fang Xiaoyan Tao Shumei Wang Guodong Liang
author_facet	Jinning Yu Hao Li Qing Tang Simon Rayner Na Han Zhenyang Guo Haizhou Liu James Adams Wei Fang Xiaoyan Tao Shumei Wang Guodong Liang
author_sort	Jinning Yu
title	The spatial and temporal dynamics of rabies in China.
title_short	The spatial and temporal dynamics of rabies in China.
title_full	The spatial and temporal dynamics of rabies in China.
title_fullStr	The spatial and temporal dynamics of rabies in China.
title_full_unstemmed	The spatial and temporal dynamics of rabies in China.
title_sort	spatial and temporal dynamics of rabies in china.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/83e8c7aefce54fd780a24964c55c8211
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The spatial and temporal dynamics of rabies in China.

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