Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.

The use of cannabis can impair cognitive function, especially short-term memory. A controversial question is whether long-term cannabis use during the late-adolescence period can cause irreversible deficits in higher brain function that persist after drug use stops. In order to examine the short- an...

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Autores principales:	Hila Abush, Irit Akirav
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/83ea674a27594e9c9d163ecf8439f85c
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spelling	oai:doaj.org-article:83ea674a27594e9c9d163ecf8439f85c2021-11-18T07:28:24ZShort- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.1932-620310.1371/journal.pone.0031731https://doaj.org/article/83ea674a27594e9c9d163ecf8439f85c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22348124/?tool=EBIhttps://doaj.org/toc/1932-6203The use of cannabis can impair cognitive function, especially short-term memory. A controversial question is whether long-term cannabis use during the late-adolescence period can cause irreversible deficits in higher brain function that persist after drug use stops. In order to examine the short- and long-term effects of chronic exposure to cannabinoids, rats were administered chronic i.p. treatment with the CB1/CB2 receptor agonist WIN55,212-2 (WIN; 1.2 mg/kg) for two weeks during the late adolescence period (post-natal days 45-60) and tested for behavioral and electrophysiological measures of cognitive performance 24 hrs, 10 and 30 days after the last drug injection. The impairing effects of chronic WIN on short-term memory in the water maze and the object recognition tasks as well as long-term potentiation (LTP) in the ventral subiculum (vSub)-nucleus accumbens (NAc) pathway were temporary as they lasted only 24 h or 10 d after withdrawal. However, chronic WIN significantly impaired hippocampal dependent short-term memory measured in the object location task 24 hrs, 10, 30, and 75 days after the last drug injection. Our findings suggest that some forms of hippocampal-dependent short-term memory are sensitive to chronic cannabinoid administration but other cognitive impairments are temporary and probably result from a residue of cannabinoids in the brain or acute withdrawal effects from cannabinoids. Understanding the effects of cannabinoids on cognitive function may provide us with tools to overcome these impairments and for cannabinoids to be more favorably considered for clinical use.Hila AbushIrit AkiravPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31731 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hila Abush Irit Akirav Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.
description	The use of cannabis can impair cognitive function, especially short-term memory. A controversial question is whether long-term cannabis use during the late-adolescence period can cause irreversible deficits in higher brain function that persist after drug use stops. In order to examine the short- and long-term effects of chronic exposure to cannabinoids, rats were administered chronic i.p. treatment with the CB1/CB2 receptor agonist WIN55,212-2 (WIN; 1.2 mg/kg) for two weeks during the late adolescence period (post-natal days 45-60) and tested for behavioral and electrophysiological measures of cognitive performance 24 hrs, 10 and 30 days after the last drug injection. The impairing effects of chronic WIN on short-term memory in the water maze and the object recognition tasks as well as long-term potentiation (LTP) in the ventral subiculum (vSub)-nucleus accumbens (NAc) pathway were temporary as they lasted only 24 h or 10 d after withdrawal. However, chronic WIN significantly impaired hippocampal dependent short-term memory measured in the object location task 24 hrs, 10, 30, and 75 days after the last drug injection. Our findings suggest that some forms of hippocampal-dependent short-term memory are sensitive to chronic cannabinoid administration but other cognitive impairments are temporary and probably result from a residue of cannabinoids in the brain or acute withdrawal effects from cannabinoids. Understanding the effects of cannabinoids on cognitive function may provide us with tools to overcome these impairments and for cannabinoids to be more favorably considered for clinical use.
format	article
author	Hila Abush Irit Akirav
author_facet	Hila Abush Irit Akirav
author_sort	Hila Abush
title	Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.
title_short	Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.
title_full	Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.
title_fullStr	Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.
title_full_unstemmed	Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.
title_sort	short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/83ea674a27594e9c9d163ecf8439f85c
work_keys_str_mv	AT hilaabush shortandlongtermcognitiveeffectsofchroniccannabinoidsadministrationinlateadolescencerats AT iritakirav shortandlongtermcognitiveeffectsofchroniccannabinoidsadministrationinlateadolescencerats
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Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats.

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