Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with genetic loci associated with cardiac phenotyp...

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Autores principales:	Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser, Bernard D. Keavney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/83ebcba231fa46148d8363dbe91cb2fe
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spelling	oai:doaj.org-article:83ebcba231fa46148d8363dbe91cb2fe2021-12-02T16:49:36ZPromoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks10.1038/s41467-018-04931-02041-1723https://doaj.org/article/83ebcba231fa46148d8363dbe91cb2fe2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04931-0https://doaj.org/toc/2041-1723Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with genetic loci associated with cardiac phenotypes.Mun-Kit ChoyBiola M. JavierreSimon G. WilliamsStephanie L. BarossYingjuan LiuSteven W. WingettArtur AkbarovChris WallacePaula Freire-PritchettPeter J. Rugg-GunnMikhail SpivakovPeter FraserBernard D. KeavneyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mun-Kit Choy Biola M. Javierre Simon G. Williams Stephanie L. Baross Yingjuan Liu Steven W. Wingett Artur Akbarov Chris Wallace Paula Freire-Pritchett Peter J. Rugg-Gunn Mikhail Spivakov Peter Fraser Bernard D. Keavney Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
description	Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with genetic loci associated with cardiac phenotypes.
format	article
author	Mun-Kit Choy Biola M. Javierre Simon G. Williams Stephanie L. Baross Yingjuan Liu Steven W. Wingett Artur Akbarov Chris Wallace Paula Freire-Pritchett Peter J. Rugg-Gunn Mikhail Spivakov Peter Fraser Bernard D. Keavney
author_facet	Mun-Kit Choy Biola M. Javierre Simon G. Williams Stephanie L. Baross Yingjuan Liu Steven W. Wingett Artur Akbarov Chris Wallace Paula Freire-Pritchett Peter J. Rugg-Gunn Mikhail Spivakov Peter Fraser Bernard D. Keavney
author_sort	Mun-Kit Choy
title	Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
title_short	Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
title_full	Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
title_fullStr	Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
title_full_unstemmed	Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
title_sort	promoter interactome of human embryonic stem cell-derived cardiomyocytes connects gwas regions to cardiac gene networks
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/83ebcba231fa46148d8363dbe91cb2fe
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Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

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