A decomposable silica-based antibacterial coating for percutaneous titanium implant

Jia Wang,1,* Guofeng Wu,2,* Xiangwei Liu,3,* Guanyang Sun,1 Dehua Li,3 Hongbo Wei3 1State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Mili...

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Autores principales:	Wang J, Wu G, Liu X, Sun G, Li D, Wei H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	silica nanoparticles microarc-oxidation gentamycin control release fibroblasts Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/83ef0e551da0407c888ca09b27c90e57
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spelling	oai:doaj.org-article:83ef0e551da0407c888ca09b27c90e572021-12-02T05:00:27ZA decomposable silica-based antibacterial coating for percutaneous titanium implant1178-2013https://doaj.org/article/83ef0e551da0407c888ca09b27c90e572017-01-01T00:00:00Zhttps://www.dovepress.com/a-decomposable-silica-based-antibacterial-coating-for-percutaneous-tit-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jia Wang,1,* Guofeng Wu,2,* Xiangwei Liu,3,* Guanyang Sun,1 Dehua Li,3 Hongbo Wei3 1State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, 2Department of Prosthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 3State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China *These authors contributed equally to this work Abstract: Although percutaneous titanium implants have become one of the best choices as retainers in the facial defects, peri-implantitis still occurs at a significant rate. This unwanted complication occurs due to adhesion of bacteria and subsequent biofilm formation. To solve this problem, we have developed a novel antibiotic nanodelivery system based on self-decomposable silica nanoparticles. In this study, silica-gentamycin (SG) nanoparticles were successfully fabricated using an innovative one-pot solution. The nanoparticles were incorporated within a gelatin matrix and cross-linked on microarc-oxidized titanium. To characterize the SG nanoparticles, their particle size, zeta potential, surface morphology, in vitro drug release, and decomposition process were sequentially evaluated. The antibacterial properties against the gram-positive Staphylococcus aureus, including bacterial viability, antibacterial rate, and bacteria morphology, were analyzed using SG-loaded titanium specimens. Any possible influence of released gentamycin on the viability of human fibroblasts, which are the main component of soft tissues, was investigated. SG nanoparticles from the antibacterial titanium coating continuously released gentamycin and inhibited S. aureus growth. In vitro investigation showed that the obtained nanodelivery system has good biocompatibility. Therefore, this design can be further investigated as a method to prevent infection around percutaneous implants. Keywords: silica nanoparticles, microarc oxidation, gentamycin, control release, fibroblastsWang JWu GLiu XSun GLi DWei HDove Medical Pressarticlesilica nanoparticlesmicroarc-oxidationgentamycincontrol releasefibroblastsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 371-379 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	silica nanoparticles microarc-oxidation gentamycin control release fibroblasts Medicine (General) R5-920
spellingShingle	silica nanoparticles microarc-oxidation gentamycin control release fibroblasts Medicine (General) R5-920 Wang J Wu G Liu X Sun G Li D Wei H A decomposable silica-based antibacterial coating for percutaneous titanium implant
description	Jia Wang,1,* Guofeng Wu,2,* Xiangwei Liu,3,* Guanyang Sun,1 Dehua Li,3 Hongbo Wei3 1State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, 2Department of Prosthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 3State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China *These authors contributed equally to this work Abstract: Although percutaneous titanium implants have become one of the best choices as retainers in the facial defects, peri-implantitis still occurs at a significant rate. This unwanted complication occurs due to adhesion of bacteria and subsequent biofilm formation. To solve this problem, we have developed a novel antibiotic nanodelivery system based on self-decomposable silica nanoparticles. In this study, silica-gentamycin (SG) nanoparticles were successfully fabricated using an innovative one-pot solution. The nanoparticles were incorporated within a gelatin matrix and cross-linked on microarc-oxidized titanium. To characterize the SG nanoparticles, their particle size, zeta potential, surface morphology, in vitro drug release, and decomposition process were sequentially evaluated. The antibacterial properties against the gram-positive Staphylococcus aureus, including bacterial viability, antibacterial rate, and bacteria morphology, were analyzed using SG-loaded titanium specimens. Any possible influence of released gentamycin on the viability of human fibroblasts, which are the main component of soft tissues, was investigated. SG nanoparticles from the antibacterial titanium coating continuously released gentamycin and inhibited S. aureus growth. In vitro investigation showed that the obtained nanodelivery system has good biocompatibility. Therefore, this design can be further investigated as a method to prevent infection around percutaneous implants. Keywords: silica nanoparticles, microarc oxidation, gentamycin, control release, fibroblasts
format	article
author	Wang J Wu G Liu X Sun G Li D Wei H
author_facet	Wang J Wu G Liu X Sun G Li D Wei H
author_sort	Wang J
title	A decomposable silica-based antibacterial coating for percutaneous titanium implant
title_short	A decomposable silica-based antibacterial coating for percutaneous titanium implant
title_full	A decomposable silica-based antibacterial coating for percutaneous titanium implant
title_fullStr	A decomposable silica-based antibacterial coating for percutaneous titanium implant
title_full_unstemmed	A decomposable silica-based antibacterial coating for percutaneous titanium implant
title_sort	decomposable silica-based antibacterial coating for percutaneous titanium implant
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/83ef0e551da0407c888ca09b27c90e57
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A decomposable silica-based antibacterial coating for percutaneous titanium implant

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