The chromatin remodeler SPLAYED regulates specific stress signaling pathways.

Organisms are continuously exposed to a myriad of environmental stresses. Central to an organism's survival is the ability to mount a robust transcriptional response to the imposed stress. An emerging mechanism of transcriptional control involves dynamic changes in chromatin structure. Alterati...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Justin W Walley, Heather C Rowe, Yanmei Xiao, E Wassim Chehab, Daniel J Kliebenstein, Doris Wagner, Katayoon Dehesh
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/83ef6c7e387f476f9f5e1ef88553419f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:83ef6c7e387f476f9f5e1ef88553419f
record_format	dspace
spelling	oai:doaj.org-article:83ef6c7e387f476f9f5e1ef88553419f2021-11-25T05:47:23ZThe chromatin remodeler SPLAYED regulates specific stress signaling pathways.1553-73661553-737410.1371/journal.ppat.1000237https://doaj.org/article/83ef6c7e387f476f9f5e1ef88553419f2008-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19079584/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Organisms are continuously exposed to a myriad of environmental stresses. Central to an organism's survival is the ability to mount a robust transcriptional response to the imposed stress. An emerging mechanism of transcriptional control involves dynamic changes in chromatin structure. Alterations in chromatin structure are brought about by a number of different mechanisms, including chromatin modifications, which covalently modify histone proteins; incorporation of histone variants; and chromatin remodeling, which utilizes ATP hydrolysis to alter histone-DNA contacts. While considerable insight into the mechanisms of chromatin remodeling has been gained, the biological role of chromatin remodeling complexes beyond their function as regulators of cellular differentiation and development has remained poorly understood. Here, we provide genetic, biochemical, and biological evidence for the critical role of chromatin remodeling in mediating plant defense against specific biotic stresses. We found that the Arabidopsis SWI/SNF class chromatin remodeling ATPase SPLAYED (SYD) is required for the expression of selected genes downstream of the jasmonate (JA) and ethylene (ET) signaling pathways. SYD is also directly recruited to the promoters of several of these genes. Furthermore, we show that SYD is required for resistance against the necrotrophic pathogen Botrytis cinerea but not the biotrophic pathogen Pseudomonas syringae. These findings demonstrate not only that chromatin remodeling is required for selective pathogen resistance, but also that chromatin remodelers such as SYD can regulate specific pathways within biotic stress signaling networks.Justin W WalleyHeather C RoweYanmei XiaoE Wassim ChehabDaniel J KliebensteinDoris WagnerKatayoon DeheshPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 12, p e1000237 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Justin W Walley Heather C Rowe Yanmei Xiao E Wassim Chehab Daniel J Kliebenstein Doris Wagner Katayoon Dehesh The chromatin remodeler SPLAYED regulates specific stress signaling pathways.
description	Organisms are continuously exposed to a myriad of environmental stresses. Central to an organism's survival is the ability to mount a robust transcriptional response to the imposed stress. An emerging mechanism of transcriptional control involves dynamic changes in chromatin structure. Alterations in chromatin structure are brought about by a number of different mechanisms, including chromatin modifications, which covalently modify histone proteins; incorporation of histone variants; and chromatin remodeling, which utilizes ATP hydrolysis to alter histone-DNA contacts. While considerable insight into the mechanisms of chromatin remodeling has been gained, the biological role of chromatin remodeling complexes beyond their function as regulators of cellular differentiation and development has remained poorly understood. Here, we provide genetic, biochemical, and biological evidence for the critical role of chromatin remodeling in mediating plant defense against specific biotic stresses. We found that the Arabidopsis SWI/SNF class chromatin remodeling ATPase SPLAYED (SYD) is required for the expression of selected genes downstream of the jasmonate (JA) and ethylene (ET) signaling pathways. SYD is also directly recruited to the promoters of several of these genes. Furthermore, we show that SYD is required for resistance against the necrotrophic pathogen Botrytis cinerea but not the biotrophic pathogen Pseudomonas syringae. These findings demonstrate not only that chromatin remodeling is required for selective pathogen resistance, but also that chromatin remodelers such as SYD can regulate specific pathways within biotic stress signaling networks.
format	article
author	Justin W Walley Heather C Rowe Yanmei Xiao E Wassim Chehab Daniel J Kliebenstein Doris Wagner Katayoon Dehesh
author_facet	Justin W Walley Heather C Rowe Yanmei Xiao E Wassim Chehab Daniel J Kliebenstein Doris Wagner Katayoon Dehesh
author_sort	Justin W Walley
title	The chromatin remodeler SPLAYED regulates specific stress signaling pathways.
title_short	The chromatin remodeler SPLAYED regulates specific stress signaling pathways.
title_full	The chromatin remodeler SPLAYED regulates specific stress signaling pathways.
title_fullStr	The chromatin remodeler SPLAYED regulates specific stress signaling pathways.
title_full_unstemmed	The chromatin remodeler SPLAYED regulates specific stress signaling pathways.
title_sort	chromatin remodeler splayed regulates specific stress signaling pathways.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/83ef6c7e387f476f9f5e1ef88553419f
work_keys_str_mv	AT justinwwalley thechromatinremodelersplayedregulatesspecificstresssignalingpathways AT heathercrowe thechromatinremodelersplayedregulatesspecificstresssignalingpathways AT yanmeixiao thechromatinremodelersplayedregulatesspecificstresssignalingpathways AT ewassimchehab thechromatinremodelersplayedregulatesspecificstresssignalingpathways AT danieljkliebenstein thechromatinremodelersplayedregulatesspecificstresssignalingpathways AT doriswagner thechromatinremodelersplayedregulatesspecificstresssignalingpathways AT katayoondehesh thechromatinremodelersplayedregulatesspecificstresssignalingpathways AT justinwwalley chromatinremodelersplayedregulatesspecificstresssignalingpathways AT heathercrowe chromatinremodelersplayedregulatesspecificstresssignalingpathways AT yanmeixiao chromatinremodelersplayedregulatesspecificstresssignalingpathways AT ewassimchehab chromatinremodelersplayedregulatesspecificstresssignalingpathways AT danieljkliebenstein chromatinremodelersplayedregulatesspecificstresssignalingpathways AT doriswagner chromatinremodelersplayedregulatesspecificstresssignalingpathways AT katayoondehesh chromatinremodelersplayedregulatesspecificstresssignalingpathways
_version_	1718414466725445632

The chromatin remodeler SPLAYED regulates specific stress signaling pathways.

Ejemplares similares