RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview

Growth factors (GFs) are bioactive molecules participating in organ development, tissue regeneration and repair. They are protein molecules with a relatively low molecular weight and are released by activated platelets. Platelet-derived growth factor (PDGF) is one of the GFs of highest amount in hum...

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Autores principales:	Mihaylova Z., Ugrinov R., Aleksiev E., Stanimirov P.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	growth factors platelet-derived growth factor pdgf oral surgery Medicine R
Acceso en línea:	https://doaj.org/article/83f138091d4346239da3f6af68a55692
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id	oai:doaj.org-article:83f138091d4346239da3f6af68a55692
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spelling	oai:doaj.org-article:83f138091d4346239da3f6af68a556922021-12-02T19:05:13ZRhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview0324-175010.2478/amb-2020-0037https://doaj.org/article/83f138091d4346239da3f6af68a556922020-09-01T00:00:00Zhttps://doi.org/10.2478/amb-2020-0037https://doaj.org/toc/0324-1750Growth factors (GFs) are bioactive molecules participating in organ development, tissue regeneration and repair. They are protein molecules with a relatively low molecular weight and are released by activated platelets. Platelet-derived growth factor (PDGF) is one of the GFs of highest amount in human platelets. It is known to stimulate cell proliferation and extracellular matrix synthesis, as well as angiogenesis in healthy tissues and neoplasms. However, most of the studies in the literature demonstrate the influence of PDGF on tissue regeneration without revealing its intimate mechanisms of action on different cell types. In the current review we emphasis on the effects of PDGF in order to stimulate various biological processes in wide number of pre-clinical and clinical studies.Mihaylova Z.Ugrinov R.Aleksiev E.Stanimirov P.Sciendoarticlegrowth factorsplatelet-derived growth factorpdgforal surgeryMedicineRENActa Medica Bulgarica, Vol 47, Iss 3, Pp 61-66 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	growth factors platelet-derived growth factor pdgf oral surgery Medicine R
spellingShingle	growth factors platelet-derived growth factor pdgf oral surgery Medicine R Mihaylova Z. Ugrinov R. Aleksiev E. Stanimirov P. RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview
description	Growth factors (GFs) are bioactive molecules participating in organ development, tissue regeneration and repair. They are protein molecules with a relatively low molecular weight and are released by activated platelets. Platelet-derived growth factor (PDGF) is one of the GFs of highest amount in human platelets. It is known to stimulate cell proliferation and extracellular matrix synthesis, as well as angiogenesis in healthy tissues and neoplasms. However, most of the studies in the literature demonstrate the influence of PDGF on tissue regeneration without revealing its intimate mechanisms of action on different cell types. In the current review we emphasis on the effects of PDGF in order to stimulate various biological processes in wide number of pre-clinical and clinical studies.
format	article
author	Mihaylova Z. Ugrinov R. Aleksiev E. Stanimirov P.
author_facet	Mihaylova Z. Ugrinov R. Aleksiev E. Stanimirov P.
author_sort	Mihaylova Z.
title	RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview
title_short	RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview
title_full	RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview
title_fullStr	RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview
title_full_unstemmed	RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview
title_sort	rhpdgf – basic characteristics and potential application in the oral surgery – an overview
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/83f138091d4346239da3f6af68a55692
work_keys_str_mv	AT mihaylovaz rhpdgfbasiccharacteristicsandpotentialapplicationintheoralsurgeryanoverview AT ugrinovr rhpdgfbasiccharacteristicsandpotentialapplicationintheoralsurgeryanoverview AT aleksieve rhpdgfbasiccharacteristicsandpotentialapplicationintheoralsurgeryanoverview AT stanimirovp rhpdgfbasiccharacteristicsandpotentialapplicationintheoralsurgeryanoverview
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RhPDGF – Basic Characteristics and Potential Application in the Oral Surgery – An Overview

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