A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy

Congyu Wu1, Cong Yu1, Maoquan Chu1,21School of Life Science and Technology, 2The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai, People&#39;s Republic of ChinaAbstract: Gold (Au) nanoshells with solid silica cores have great potential for cancer phototherm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wu CY, Yu C, Chu MQ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/83f51a444fb3483caa85354d0241d580
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:83f51a444fb3483caa85354d0241d580
record_format	dspace
spelling	oai:doaj.org-article:83f51a444fb3483caa85354d0241d5802021-12-02T07:47:00ZA gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy1176-91141178-2013https://doaj.org/article/83f51a444fb3483caa85354d0241d5802011-04-01T00:00:00Zhttp://www.dovepress.com/a-gold-nanoshell-with-a-silica-inner-shell-synthesized-using-liposome--a7193https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Congyu Wu1, Cong Yu1, Maoquan Chu1,21School of Life Science and Technology, 2The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai, People&#39;s Republic of ChinaAbstract: Gold (Au) nanoshells with solid silica cores have great potential for cancer photothermal therapy. However, this nanostructure cannot carry enough drugs. Here, we report a Au nanoshell with a hollow silica core for drug loading and cancer therapy. The silica shells were synthesized using nanoliposome templates, and then Au nanoshells were grown on the outer surface of the silica shells. Transmission-electron and scanning-electron microscopy showed that the Au nanoshells were successfully fabricated, and that the liposome/SiO2/Au core-shell nanocomposites were spherical with a narrow size distribution. Images of several broken spheres, and the fact that hollow templates (liposomes) were used, suggest that the fabricated Au nanoshells were hollow. After doxorubicin (DOX) was incorporated into liposome/SiO2/Au, the DOX-loaded Au nanoshells killed cancer cells with high therapeutic efficacy when irradiated with near-infrared light, suggesting that the Au nanoshells delivered both DOX chemotherapy and photothermal therapy with a synergistic effect.Keywords: gold nanoshell, liposome template, synthesis, doxorubicin, cancer therapy Wu CYYu CChu MQDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 807-813 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wu CY Yu C Chu MQ A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy
description	Congyu Wu1, Cong Yu1, Maoquan Chu1,21School of Life Science and Technology, 2The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai, People&#39;s Republic of ChinaAbstract: Gold (Au) nanoshells with solid silica cores have great potential for cancer photothermal therapy. However, this nanostructure cannot carry enough drugs. Here, we report a Au nanoshell with a hollow silica core for drug loading and cancer therapy. The silica shells were synthesized using nanoliposome templates, and then Au nanoshells were grown on the outer surface of the silica shells. Transmission-electron and scanning-electron microscopy showed that the Au nanoshells were successfully fabricated, and that the liposome/SiO2/Au core-shell nanocomposites were spherical with a narrow size distribution. Images of several broken spheres, and the fact that hollow templates (liposomes) were used, suggest that the fabricated Au nanoshells were hollow. After doxorubicin (DOX) was incorporated into liposome/SiO2/Au, the DOX-loaded Au nanoshells killed cancer cells with high therapeutic efficacy when irradiated with near-infrared light, suggesting that the Au nanoshells delivered both DOX chemotherapy and photothermal therapy with a synergistic effect.Keywords: gold nanoshell, liposome template, synthesis, doxorubicin, cancer therapy
format	article
author	Wu CY Yu C Chu MQ
author_facet	Wu CY Yu C Chu MQ
author_sort	Wu CY
title	A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy
title_short	A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy
title_full	A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy
title_fullStr	A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy
title_full_unstemmed	A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy
title_sort	gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/83f51a444fb3483caa85354d0241d580
work_keys_str_mv	AT wucy agoldnanoshellwithasilicainnershellsynthesizedusingliposometemplatesfordoxorubicinloadingandnearinfraredphotothermaltherapy AT yuc agoldnanoshellwithasilicainnershellsynthesizedusingliposometemplatesfordoxorubicinloadingandnearinfraredphotothermaltherapy AT chumq agoldnanoshellwithasilicainnershellsynthesizedusingliposometemplatesfordoxorubicinloadingandnearinfraredphotothermaltherapy AT wucy goldnanoshellwithasilicainnershellsynthesizedusingliposometemplatesfordoxorubicinloadingandnearinfraredphotothermaltherapy AT yuc goldnanoshellwithasilicainnershellsynthesizedusingliposometemplatesfordoxorubicinloadingandnearinfraredphotothermaltherapy AT chumq goldnanoshellwithasilicainnershellsynthesizedusingliposometemplatesfordoxorubicinloadingandnearinfraredphotothermaltherapy
_version_	1718399166596513792

A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy

Ejemplares similares