X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study
The growing field of cellular therapies in regenerative medicine and oncology calls for more refined diagnostic tools that are able to investigate and monitor the function and success of said therapies. X-ray Fluorescence Imaging (XFI) can be applied for molecular imaging with nanoparticles, such as...
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MDPI AG
2021
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oai:doaj.org-article:83f6cd08b999442384ffa2d85373a4682021-11-25T17:03:43ZX-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study10.3390/cancers132257592072-6694https://doaj.org/article/83f6cd08b999442384ffa2d85373a4682021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5759https://doaj.org/toc/2072-6694The growing field of cellular therapies in regenerative medicine and oncology calls for more refined diagnostic tools that are able to investigate and monitor the function and success of said therapies. X-ray Fluorescence Imaging (XFI) can be applied for molecular imaging with nanoparticles, such as gold nanoparticles (GNPs), which can be used in immune cell tracking. We present a Monte Carlo simulation study on the sensitivity of detection and associated radiation dose estimations in an idealized setup of XFI in human-sized objects. Our findings demonstrate the practicability of XFI in human-sized objects, as immune cell tracking with a minimum detection limit of 4.4 × 10<sup>5</sup> cells or 0.86 μg gold in a cubic volume of 1.78 mm<sup>3</sup> can be achieved. Therefore, our results show that the current technological developments form a good basis for high sensitivity XFI.Arthur UngererTheresa StauferOliver SchmutzlerChristian KörnigKai RothkammFlorian GrünerMDPI AGarticleX-ray fluorescenceXFIGEANT4immune celltrackingimmunotherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5759, p 5759 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
X-ray fluorescence XFI GEANT4 immune cell tracking immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
X-ray fluorescence XFI GEANT4 immune cell tracking immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Arthur Ungerer Theresa Staufer Oliver Schmutzler Christian Körnig Kai Rothkamm Florian Grüner X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study |
| description |
The growing field of cellular therapies in regenerative medicine and oncology calls for more refined diagnostic tools that are able to investigate and monitor the function and success of said therapies. X-ray Fluorescence Imaging (XFI) can be applied for molecular imaging with nanoparticles, such as gold nanoparticles (GNPs), which can be used in immune cell tracking. We present a Monte Carlo simulation study on the sensitivity of detection and associated radiation dose estimations in an idealized setup of XFI in human-sized objects. Our findings demonstrate the practicability of XFI in human-sized objects, as immune cell tracking with a minimum detection limit of 4.4 × 10<sup>5</sup> cells or 0.86 μg gold in a cubic volume of 1.78 mm<sup>3</sup> can be achieved. Therefore, our results show that the current technological developments form a good basis for high sensitivity XFI. |
| format |
article |
| author |
Arthur Ungerer Theresa Staufer Oliver Schmutzler Christian Körnig Kai Rothkamm Florian Grüner |
| author_facet |
Arthur Ungerer Theresa Staufer Oliver Schmutzler Christian Körnig Kai Rothkamm Florian Grüner |
| author_sort |
Arthur Ungerer |
| title |
X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study |
| title_short |
X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study |
| title_full |
X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study |
| title_fullStr |
X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study |
| title_full_unstemmed |
X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study |
| title_sort |
x-ray-fluorescence imaging for in vivo detection of gold-nanoparticle-labeled immune cells: a geant4 based feasibility study |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/83f6cd08b999442384ffa2d85373a468 |
| work_keys_str_mv |
AT arthurungerer xrayfluorescenceimagingforinvivodetectionofgoldnanoparticlelabeledimmunecellsageant4basedfeasibilitystudy AT theresastaufer xrayfluorescenceimagingforinvivodetectionofgoldnanoparticlelabeledimmunecellsageant4basedfeasibilitystudy AT oliverschmutzler xrayfluorescenceimagingforinvivodetectionofgoldnanoparticlelabeledimmunecellsageant4basedfeasibilitystudy AT christiankornig xrayfluorescenceimagingforinvivodetectionofgoldnanoparticlelabeledimmunecellsageant4basedfeasibilitystudy AT kairothkamm xrayfluorescenceimagingforinvivodetectionofgoldnanoparticlelabeledimmunecellsageant4basedfeasibilitystudy AT floriangruner xrayfluorescenceimagingforinvivodetectionofgoldnanoparticlelabeledimmunecellsageant4basedfeasibilitystudy |
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