Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis

Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis

Abstract Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (ΔF508 CFTR) is a major cause of cystic fibrosis (CF), one of the most common inherited childhood diseases. ΔF508 CFTR is a trafficking mutant that is retained in the endoplasmic reticulum (ER) and unab...

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Autores principales: R. Reilly, M. S. Mroz, E. Dempsey, K. Wynne, S. J. Keely, E. F. McKone, C. Hiebel, C. Behl, J. A. Coppinger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/83f7d91151ee4471ab8b716bf6da8bf0
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