Lateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies

Abstract The bilateral effects of deep brain stimulation (DBS) on motor and non-motor symptoms of Parkinson’s disease (PD) have been extensively studied and reviewed. However, the unilateral effects—in particular, the potential lateralized effects of left- versus right-sided DBS—have not been adequa...

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Autores principales:	Zhengyu Lin, Chencheng Zhang, Dianyou Li, Bomin Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/83fb30bd7d754261b7637dc1c7303036
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spelling	oai:doaj.org-article:83fb30bd7d754261b7637dc1c73030362021-12-02T17:57:16ZLateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies10.1038/s41531-021-00209-32373-8057https://doaj.org/article/83fb30bd7d754261b7637dc1c73030362021-07-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00209-3https://doaj.org/toc/2373-8057Abstract The bilateral effects of deep brain stimulation (DBS) on motor and non-motor symptoms of Parkinson’s disease (PD) have been extensively studied and reviewed. However, the unilateral effects—in particular, the potential lateralized effects of left- versus right-sided DBS—have not been adequately recognized or studied. Here we summarized the current evidence and controversies in the literature regarding the lateralized effects of DBS on motor and non-motor outcomes in PD patients. Publications in English language before February 2021 were obtained from the PubMed database and included if they directly compared the effects of unilateral versus contralateral side DBS on motor or non-motor outcomes in PD. The current literature is overall of low-quality and is biased by various confounders. Researchers have investigated mainly PD patients receiving subthalamic nucleus (STN) DBS while the potential lateralized effects of globus pallidus interna (GPi) DBS have not been adequately studied. Evidence suggests potential lateralized effects of STN DBS on axial motor symptoms and deleterious effects of left-sided DBS on language-related functions, in particular, the verbal fluency, in PD. The lateralized DBS effects on appendicular motor symptoms as well as other neurocognitive and neuropsychiatric domains remain inconclusive. Future studies should control for varying methodological approaches as well as clinical and DBS management heterogeneities, including symptom laterality, stimulation parameters, location of active contacts, and lead trajectories. This would contribute to improved treatment strategies such as personalized target selection, surgical planning, and postoperative management that ultimately benefit patients.Zhengyu LinChencheng ZhangDianyou LiBomin SunNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Zhengyu Lin Chencheng Zhang Dianyou Li Bomin Sun Lateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies
description	Abstract The bilateral effects of deep brain stimulation (DBS) on motor and non-motor symptoms of Parkinson’s disease (PD) have been extensively studied and reviewed. However, the unilateral effects—in particular, the potential lateralized effects of left- versus right-sided DBS—have not been adequately recognized or studied. Here we summarized the current evidence and controversies in the literature regarding the lateralized effects of DBS on motor and non-motor outcomes in PD patients. Publications in English language before February 2021 were obtained from the PubMed database and included if they directly compared the effects of unilateral versus contralateral side DBS on motor or non-motor outcomes in PD. The current literature is overall of low-quality and is biased by various confounders. Researchers have investigated mainly PD patients receiving subthalamic nucleus (STN) DBS while the potential lateralized effects of globus pallidus interna (GPi) DBS have not been adequately studied. Evidence suggests potential lateralized effects of STN DBS on axial motor symptoms and deleterious effects of left-sided DBS on language-related functions, in particular, the verbal fluency, in PD. The lateralized DBS effects on appendicular motor symptoms as well as other neurocognitive and neuropsychiatric domains remain inconclusive. Future studies should control for varying methodological approaches as well as clinical and DBS management heterogeneities, including symptom laterality, stimulation parameters, location of active contacts, and lead trajectories. This would contribute to improved treatment strategies such as personalized target selection, surgical planning, and postoperative management that ultimately benefit patients.
format	article
author	Zhengyu Lin Chencheng Zhang Dianyou Li Bomin Sun
author_facet	Zhengyu Lin Chencheng Zhang Dianyou Li Bomin Sun
author_sort	Zhengyu Lin
title	Lateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies
title_short	Lateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies
title_full	Lateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies
title_fullStr	Lateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies
title_full_unstemmed	Lateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies
title_sort	lateralized effects of deep brain stimulation in parkinson’s disease: evidence and controversies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/83fb30bd7d754261b7637dc1c7303036
work_keys_str_mv	AT zhengyulin lateralizedeffectsofdeepbrainstimulationinparkinsonsdiseaseevidenceandcontroversies AT chenchengzhang lateralizedeffectsofdeepbrainstimulationinparkinsonsdiseaseevidenceandcontroversies AT dianyouli lateralizedeffectsofdeepbrainstimulationinparkinsonsdiseaseevidenceandcontroversies AT bominsun lateralizedeffectsofdeepbrainstimulationinparkinsonsdiseaseevidenceandcontroversies
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Lateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies

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