Analysis of three-dimensional bone mineral density and bone strength measured by quantitative computed tomography following denosumab discontinuation in a patient with postmenopausal osteoporosis
Koki Tsuchiya,1 Koji Ishikawa,1 Soji Tani,1 Yusuke Oshita,2 Takuma Kuroda,1 Ryo Yamamura,1 Haruka Emori,1 Hiroshi Maruyama,1 Akira Matsuoka,1 Yoshifumi Kudo,1 Toshiyuki Shirahata,1 Tomoaki Toyone,1 Takashi Nagai,1 Katsunori Inagaki11Department of Orthopaedic Surgery, Showa University School of Medic...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/83feef2d327745fc95d18ffd877e824c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:83feef2d327745fc95d18ffd877e824c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:83feef2d327745fc95d18ffd877e824c2021-12-02T08:38:18ZAnalysis of three-dimensional bone mineral density and bone strength measured by quantitative computed tomography following denosumab discontinuation in a patient with postmenopausal osteoporosis1178-1998https://doaj.org/article/83feef2d327745fc95d18ffd877e824c2019-08-01T00:00:00Zhttps://www.dovepress.com/analysis-of-three-dimensional-bone-mineral-density-and-bone-strength-m-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Koki Tsuchiya,1 Koji Ishikawa,1 Soji Tani,1 Yusuke Oshita,2 Takuma Kuroda,1 Ryo Yamamura,1 Haruka Emori,1 Hiroshi Maruyama,1 Akira Matsuoka,1 Yoshifumi Kudo,1 Toshiyuki Shirahata,1 Tomoaki Toyone,1 Takashi Nagai,1 Katsunori Inagaki11Department of Orthopaedic Surgery, Showa University School of Medicine, Tokyo 142-8666, Japan; 2Department of Orthopaedic Surgery, Yamanashi Red Cross Hospital, Yamanashi, JapanAbstract: Discontinuation of denosumab during osteoporosis treatment leads to rapid loss of bone mineral density and induces a bone turnover rebound effect. Previous studies have reported analysis based on dual-energy X-ray absorptiometry scanning (DXA). Here, we report the first case involving analysis of three-dimensional bone mineral density and bone strength, measured by quantitative computed tomography (QCT) after discontinuation of denosumab. An 82-year-old woman who discontinued denosumab because of patient’s wish was administered the fifth dose after a gap of 14 months. Her bone mineral density evaluated by DXA and QCT, bone strength, and bone turnover marker levels showed significant rebound phenomenon. The levels of the cortical parameters of the hip were also decreased indicating an increased risk of femoral fractures after denosumab interruption. Our case highlights the increased risk of fractures after discontinuation of denosumab. Therefore, denosumab must be used judiciously without interruption in the dosage schedule.Keywords: lumbar spine, femoral neck, bone turnover markers, cortical bone, biomechanical analysisTsuchiya KIshikawa KTani SOshita YKuroda TYamamura REmori HMaruyama HMatsuoka AKudo YShirahata TToyone TNagai TInagaki KDove Medical Pressarticlelumbar spinefemoral neckbone turnover markerscortical bonebiomechanical analysisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1445-1450 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
lumbar spine femoral neck bone turnover markers cortical bone biomechanical analysis Geriatrics RC952-954.6 |
| spellingShingle |
lumbar spine femoral neck bone turnover markers cortical bone biomechanical analysis Geriatrics RC952-954.6 Tsuchiya K Ishikawa K Tani S Oshita Y Kuroda T Yamamura R Emori H Maruyama H Matsuoka A Kudo Y Shirahata T Toyone T Nagai T Inagaki K Analysis of three-dimensional bone mineral density and bone strength measured by quantitative computed tomography following denosumab discontinuation in a patient with postmenopausal osteoporosis |
| description |
Koki Tsuchiya,1 Koji Ishikawa,1 Soji Tani,1 Yusuke Oshita,2 Takuma Kuroda,1 Ryo Yamamura,1 Haruka Emori,1 Hiroshi Maruyama,1 Akira Matsuoka,1 Yoshifumi Kudo,1 Toshiyuki Shirahata,1 Tomoaki Toyone,1 Takashi Nagai,1 Katsunori Inagaki11Department of Orthopaedic Surgery, Showa University School of Medicine, Tokyo 142-8666, Japan; 2Department of Orthopaedic Surgery, Yamanashi Red Cross Hospital, Yamanashi, JapanAbstract: Discontinuation of denosumab during osteoporosis treatment leads to rapid loss of bone mineral density and induces a bone turnover rebound effect. Previous studies have reported analysis based on dual-energy X-ray absorptiometry scanning (DXA). Here, we report the first case involving analysis of three-dimensional bone mineral density and bone strength, measured by quantitative computed tomography (QCT) after discontinuation of denosumab. An 82-year-old woman who discontinued denosumab because of patient’s wish was administered the fifth dose after a gap of 14 months. Her bone mineral density evaluated by DXA and QCT, bone strength, and bone turnover marker levels showed significant rebound phenomenon. The levels of the cortical parameters of the hip were also decreased indicating an increased risk of femoral fractures after denosumab interruption. Our case highlights the increased risk of fractures after discontinuation of denosumab. Therefore, denosumab must be used judiciously without interruption in the dosage schedule.Keywords: lumbar spine, femoral neck, bone turnover markers, cortical bone, biomechanical analysis |
| format |
article |
| author |
Tsuchiya K Ishikawa K Tani S Oshita Y Kuroda T Yamamura R Emori H Maruyama H Matsuoka A Kudo Y Shirahata T Toyone T Nagai T Inagaki K |
| author_facet |
Tsuchiya K Ishikawa K Tani S Oshita Y Kuroda T Yamamura R Emori H Maruyama H Matsuoka A Kudo Y Shirahata T Toyone T Nagai T Inagaki K |
| author_sort |
Tsuchiya K |
| title |
Analysis of three-dimensional bone mineral density and bone strength measured by quantitative computed tomography following denosumab discontinuation in a patient with postmenopausal osteoporosis |
| title_short |
Analysis of three-dimensional bone mineral density and bone strength measured by quantitative computed tomography following denosumab discontinuation in a patient with postmenopausal osteoporosis |
| title_full |
Analysis of three-dimensional bone mineral density and bone strength measured by quantitative computed tomography following denosumab discontinuation in a patient with postmenopausal osteoporosis |
| title_fullStr |
Analysis of three-dimensional bone mineral density and bone strength measured by quantitative computed tomography following denosumab discontinuation in a patient with postmenopausal osteoporosis |
| title_full_unstemmed |
Analysis of three-dimensional bone mineral density and bone strength measured by quantitative computed tomography following denosumab discontinuation in a patient with postmenopausal osteoporosis |
| title_sort |
analysis of three-dimensional bone mineral density and bone strength measured by quantitative computed tomography following denosumab discontinuation in a patient with postmenopausal osteoporosis |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/83feef2d327745fc95d18ffd877e824c |
| work_keys_str_mv |
AT tsuchiyak analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT ishikawak analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT tanis analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT oshitay analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT kurodat analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT yamamurar analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT emorih analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT maruyamah analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT matsuokaa analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT kudoy analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT shirahatat analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT toyonet analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT nagait analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis AT inagakik analysisofthreedimensionalbonemineraldensityandbonestrengthmeasuredbyquantitativecomputedtomographyfollowingdenosumabdiscontinuationinapatientwithpostmenopausalosteoporosis |
| _version_ |
1718398423837704192 |