Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk

We know a large number of risk SNPs for schizophrenia, but little about how these SNPs contribute to the disorder. Here, the authors use functional genomics to identify risk SNPs that disrupt transcription factor binding and validate the regulatory effects of the transcription factor binding-disrupt...

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Autores principales:	Yongxia Huo, Shiwu Li, Jiewei Liu, Xiaoyan Li, Xiong-Jian Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84007106e80b429e9d5b74bc356226ca
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spelling	oai:doaj.org-article:84007106e80b429e9d5b74bc356226ca2021-12-02T14:38:59ZFunctional genomics reveal gene regulatory mechanisms underlying schizophrenia risk10.1038/s41467-019-08666-42041-1723https://doaj.org/article/84007106e80b429e9d5b74bc356226ca2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08666-4https://doaj.org/toc/2041-1723We know a large number of risk SNPs for schizophrenia, but little about how these SNPs contribute to the disorder. Here, the authors use functional genomics to identify risk SNPs that disrupt transcription factor binding and validate the regulatory effects of the transcription factor binding-disrupting SNPs.Yongxia HuoShiwu LiJiewei LiuXiaoyan LiXiong-Jian LuoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yongxia Huo Shiwu Li Jiewei Liu Xiaoyan Li Xiong-Jian Luo Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
description	We know a large number of risk SNPs for schizophrenia, but little about how these SNPs contribute to the disorder. Here, the authors use functional genomics to identify risk SNPs that disrupt transcription factor binding and validate the regulatory effects of the transcription factor binding-disrupting SNPs.
format	article
author	Yongxia Huo Shiwu Li Jiewei Liu Xiaoyan Li Xiong-Jian Luo
author_facet	Yongxia Huo Shiwu Li Jiewei Liu Xiaoyan Li Xiong-Jian Luo
author_sort	Yongxia Huo
title	Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
title_short	Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
title_full	Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
title_fullStr	Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
title_full_unstemmed	Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
title_sort	functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/84007106e80b429e9d5b74bc356226ca
work_keys_str_mv	AT yongxiahuo functionalgenomicsrevealgeneregulatorymechanismsunderlyingschizophreniarisk AT shiwuli functionalgenomicsrevealgeneregulatorymechanismsunderlyingschizophreniarisk AT jieweiliu functionalgenomicsrevealgeneregulatorymechanismsunderlyingschizophreniarisk AT xiaoyanli functionalgenomicsrevealgeneregulatorymechanismsunderlyingschizophreniarisk AT xiongjianluo functionalgenomicsrevealgeneregulatorymechanismsunderlyingschizophreniarisk
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Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk

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