Nontyphoidal Salmonella bacteremia in antiretroviral therapy-naïve HIV-infected individuals at three public hospitals in Eastern Ethiopia: prevalence, antimicrobial susceptibility patterns, and associated factors

Nontyphoidal Salmonella bacteremia in antiretroviral therapy-naïve HIV-infected individuals at three public hospitals in Eastern Ethiopia: prevalence, antimicrobial susceptibility patterns, and associated factors

Habtamu Mitiku, Fitsum Weldegebreal, Dadi Marami, Zelalem Teklemariam Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia Background: Nontyphoidal Salmonella bacteria have emerged as the prominent cause of severe and life-threatenin...

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Autores principales: Mitiku H, Weldegebreal F, Marami D, Teklemariam Z
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Salmonella
HIV
ART naïve
antibiotic resistance
Ethiopia
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/8402856a4319438fa57cece464e8b11b
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spelling oai:doaj.org-article:8402856a4319438fa57cece464e8b11b2021-12-02T00:56:46ZNontyphoidal Salmonella bacteremia in antiretroviral therapy-naïve HIV-infected individuals at three public hospitals in Eastern Ethiopia: prevalence, antimicrobial susceptibility patterns, and associated factors1179-1373https://doaj.org/article/8402856a4319438fa57cece464e8b11b2019-02-01T00:00:00Zhttps://www.dovepress.com/nontyphoidal-salmonella-bacteremia-in-antiretroviral-therapy-naiumlve--peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Habtamu Mitiku, Fitsum Weldegebreal, Dadi Marami, Zelalem Teklemariam Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia Background: Nontyphoidal Salmonella bacteria have emerged as the prominent cause of severe and life-threatening bacteremia in HIV-infected patients. Antimicrobial resistance is another concern that adversely affects the health outcome of the patients. This study investigated the prevalence, antimicrobial susceptibility pattern of the isolates, and associated factors of nontyphoidal Salmonella bacteremia among antiretroviral therapy-naïve HIV-infected adult individuals at three public hospitals in Eastern Ethiopia. Methods: A cross-sectional study was conducted among 170 antiretroviral therapy-naïve HIV-infected adult individuals in three public hospitals in Eastern Ethiopia from June 2017 to June 2018. Data on sociodemographic and associated factors were collected using a pretested structured questionnaire. Blood specimens were examined for nontyphoidal Salmonella using the recommended culture and serological methods. Data were analyzed using the Statistical Package for Social Sciences version 20.0. Bivariate and multivariate logistic regression models were used to identify the predictors of nontyphoidal Salmonella bacteremia. A P-value Results: The prevalence of nontyphoidal Salmonella bacteremia was 10% (95% CI: 5.93–15.54). A lack of hand washing habit before food preparation (adjusted odds ratio [AOR]: 13.1, 95% CI: 10.40–15.30) and a CD4+ count Conclusion: The prevalence of nontyphoidal Salmonella bacteremia was high. HIV-infected patients who did not wash their hands before food preparation and those whose CD4+ count was Keywords: prevalence, salmonellosis, HIV/AIDS, immunosuppression, drug resistance, EthiopiaMitiku HWeldegebreal FMarami DTeklemariam ZDove Medical PressarticleSalmonellaHIVART naïveantibiotic resistanceEthiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 11, Pp 23-29 (2019)
institution DOAJ
collection DOAJ
language EN
topic Salmonella
HIV
ART naïve
antibiotic resistance
Ethiopia
Immunologic diseases. Allergy
RC581-607
spellingShingle Salmonella
HIV
ART naïve
antibiotic resistance
Ethiopia
Immunologic diseases. Allergy
RC581-607
Mitiku H
Weldegebreal F
Marami D
Teklemariam Z
Nontyphoidal Salmonella bacteremia in antiretroviral therapy-naïve HIV-infected individuals at three public hospitals in Eastern Ethiopia: prevalence, antimicrobial susceptibility patterns, and associated factors
description Habtamu Mitiku, Fitsum Weldegebreal, Dadi Marami, Zelalem Teklemariam Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia Background: Nontyphoidal Salmonella bacteria have emerged as the prominent cause of severe and life-threatening bacteremia in HIV-infected patients. Antimicrobial resistance is another concern that adversely affects the health outcome of the patients. This study investigated the prevalence, antimicrobial susceptibility pattern of the isolates, and associated factors of nontyphoidal Salmonella bacteremia among antiretroviral therapy-naïve HIV-infected adult individuals at three public hospitals in Eastern Ethiopia. Methods: A cross-sectional study was conducted among 170 antiretroviral therapy-naïve HIV-infected adult individuals in three public hospitals in Eastern Ethiopia from June 2017 to June 2018. Data on sociodemographic and associated factors were collected using a pretested structured questionnaire. Blood specimens were examined for nontyphoidal Salmonella using the recommended culture and serological methods. Data were analyzed using the Statistical Package for Social Sciences version 20.0. Bivariate and multivariate logistic regression models were used to identify the predictors of nontyphoidal Salmonella bacteremia. A P-value Results: The prevalence of nontyphoidal Salmonella bacteremia was 10% (95% CI: 5.93–15.54). A lack of hand washing habit before food preparation (adjusted odds ratio [AOR]: 13.1, 95% CI: 10.40–15.30) and a CD4+ count Conclusion: The prevalence of nontyphoidal Salmonella bacteremia was high. HIV-infected patients who did not wash their hands before food preparation and those whose CD4+ count was Keywords: prevalence, salmonellosis, HIV/AIDS, immunosuppression, drug resistance, Ethiopia
format article
author Mitiku H
Weldegebreal F
Marami D
Teklemariam Z
author_facet Mitiku H
Weldegebreal F
Marami D
Teklemariam Z
author_sort Mitiku H
title Nontyphoidal Salmonella bacteremia in antiretroviral therapy-naïve HIV-infected individuals at three public hospitals in Eastern Ethiopia: prevalence, antimicrobial susceptibility patterns, and associated factors
title_short Nontyphoidal Salmonella bacteremia in antiretroviral therapy-naïve HIV-infected individuals at three public hospitals in Eastern Ethiopia: prevalence, antimicrobial susceptibility patterns, and associated factors
title_full Nontyphoidal Salmonella bacteremia in antiretroviral therapy-naïve HIV-infected individuals at three public hospitals in Eastern Ethiopia: prevalence, antimicrobial susceptibility patterns, and associated factors
title_fullStr Nontyphoidal Salmonella bacteremia in antiretroviral therapy-naïve HIV-infected individuals at three public hospitals in Eastern Ethiopia: prevalence, antimicrobial susceptibility patterns, and associated factors
title_full_unstemmed Nontyphoidal Salmonella bacteremia in antiretroviral therapy-naïve HIV-infected individuals at three public hospitals in Eastern Ethiopia: prevalence, antimicrobial susceptibility patterns, and associated factors
title_sort nontyphoidal salmonella bacteremia in antiretroviral therapy-naïve hiv-infected individuals at three public hospitals in eastern ethiopia: prevalence, antimicrobial susceptibility patterns, and associated factors
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/8402856a4319438fa57cece464e8b11b
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