SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic bou...
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oai:doaj.org-article:8405b7ea05e8461086f8fdd56ee7dec82021-12-02T16:57:31ZSIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals10.1038/s41467-019-13224-z2041-1723https://doaj.org/article/8405b7ea05e8461086f8fdd56ee7dec82019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13224-zhttps://doaj.org/toc/2041-1723There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic boutons and that SIPA1L2, a member of the SIPA1L family of neuronal RapGAPs, associates via LC3b to TrkB-containing amphisomes to regulate its motility and signaling at the axon terminalsMaria Andres-AlonsoMohamed Raafet AmmarIoana ButnaruGuilherme M. GomesGustavo Acuña SanhuezaRajeev RamanPingAn YuanxiangMaximilian BorgmeyerJeffrey Lopez-RojasSyed Ahsan RazaNicola BriceTorben J. HausratTamar MacharadzeSilvia Diaz-GonzalezMark CarltonAntonio Virgilio FaillaOliver StorkMichaela SchweizerEckart D. GundelfingerMatthias KneusselChristina SpilkerAnna KarpovaMichael R. KreutzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
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Science Q Maria Andres-Alonso Mohamed Raafet Ammar Ioana Butnaru Guilherme M. Gomes Gustavo Acuña Sanhueza Rajeev Raman PingAn Yuanxiang Maximilian Borgmeyer Jeffrey Lopez-Rojas Syed Ahsan Raza Nicola Brice Torben J. Hausrat Tamar Macharadze Silvia Diaz-Gonzalez Mark Carlton Antonio Virgilio Failla Oliver Stork Michaela Schweizer Eckart D. Gundelfinger Matthias Kneussel Christina Spilker Anna Karpova Michael R. Kreutz SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
description |
There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic boutons and that SIPA1L2, a member of the SIPA1L family of neuronal RapGAPs, associates via LC3b to TrkB-containing amphisomes to regulate its motility and signaling at the axon terminals |
format |
article |
author |
Maria Andres-Alonso Mohamed Raafet Ammar Ioana Butnaru Guilherme M. Gomes Gustavo Acuña Sanhueza Rajeev Raman PingAn Yuanxiang Maximilian Borgmeyer Jeffrey Lopez-Rojas Syed Ahsan Raza Nicola Brice Torben J. Hausrat Tamar Macharadze Silvia Diaz-Gonzalez Mark Carlton Antonio Virgilio Failla Oliver Stork Michaela Schweizer Eckart D. Gundelfinger Matthias Kneussel Christina Spilker Anna Karpova Michael R. Kreutz |
author_facet |
Maria Andres-Alonso Mohamed Raafet Ammar Ioana Butnaru Guilherme M. Gomes Gustavo Acuña Sanhueza Rajeev Raman PingAn Yuanxiang Maximilian Borgmeyer Jeffrey Lopez-Rojas Syed Ahsan Raza Nicola Brice Torben J. Hausrat Tamar Macharadze Silvia Diaz-Gonzalez Mark Carlton Antonio Virgilio Failla Oliver Stork Michaela Schweizer Eckart D. Gundelfinger Matthias Kneussel Christina Spilker Anna Karpova Michael R. Kreutz |
author_sort |
Maria Andres-Alonso |
title |
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
title_short |
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
title_full |
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
title_fullStr |
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
title_full_unstemmed |
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals |
title_sort |
sipa1l2 controls trafficking and local signaling of trkb-containing amphisomes at presynaptic terminals |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/8405b7ea05e8461086f8fdd56ee7dec8 |
work_keys_str_mv |
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