SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals

There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic bou...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Maria Andres-Alonso, Mohamed Raafet Ammar, Ioana Butnaru, Guilherme M. Gomes, Gustavo Acuña Sanhueza, Rajeev Raman, PingAn Yuanxiang, Maximilian Borgmeyer, Jeffrey Lopez-Rojas, Syed Ahsan Raza, Nicola Brice, Torben J. Hausrat, Tamar Macharadze, Silvia Diaz-Gonzalez, Mark Carlton, Antonio Virgilio Failla, Oliver Stork, Michaela Schweizer, Eckart D. Gundelfinger, Matthias Kneussel, Christina Spilker, Anna Karpova, Michael R. Kreutz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/8405b7ea05e8461086f8fdd56ee7dec8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:8405b7ea05e8461086f8fdd56ee7dec8
record_format dspace
spelling oai:doaj.org-article:8405b7ea05e8461086f8fdd56ee7dec82021-12-02T16:57:31ZSIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals10.1038/s41467-019-13224-z2041-1723https://doaj.org/article/8405b7ea05e8461086f8fdd56ee7dec82019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13224-zhttps://doaj.org/toc/2041-1723There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic boutons and that SIPA1L2, a member of the SIPA1L family of neuronal RapGAPs, associates via LC3b to TrkB-containing amphisomes to regulate its motility and signaling at the axon terminalsMaria Andres-AlonsoMohamed Raafet AmmarIoana ButnaruGuilherme M. GomesGustavo Acuña SanhuezaRajeev RamanPingAn YuanxiangMaximilian BorgmeyerJeffrey Lopez-RojasSyed Ahsan RazaNicola BriceTorben J. HausratTamar MacharadzeSilvia Diaz-GonzalezMark CarltonAntonio Virgilio FaillaOliver StorkMichaela SchweizerEckart D. GundelfingerMatthias KneusselChristina SpilkerAnna KarpovaMichael R. KreutzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Maria Andres-Alonso
Mohamed Raafet Ammar
Ioana Butnaru
Guilherme M. Gomes
Gustavo Acuña Sanhueza
Rajeev Raman
PingAn Yuanxiang
Maximilian Borgmeyer
Jeffrey Lopez-Rojas
Syed Ahsan Raza
Nicola Brice
Torben J. Hausrat
Tamar Macharadze
Silvia Diaz-Gonzalez
Mark Carlton
Antonio Virgilio Failla
Oliver Stork
Michaela Schweizer
Eckart D. Gundelfinger
Matthias Kneussel
Christina Spilker
Anna Karpova
Michael R. Kreutz
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
description There is growing evidence that autophagy might serve specialized functions in neurons besides its role in protein homeostasis. In this study, authors demonstrate that axonal retrograde transport of BDNF/TrkB in neuronal amphisomes is involved in plasticity-relevant local signaling at presynaptic boutons and that SIPA1L2, a member of the SIPA1L family of neuronal RapGAPs, associates via LC3b to TrkB-containing amphisomes to regulate its motility and signaling at the axon terminals
format article
author Maria Andres-Alonso
Mohamed Raafet Ammar
Ioana Butnaru
Guilherme M. Gomes
Gustavo Acuña Sanhueza
Rajeev Raman
PingAn Yuanxiang
Maximilian Borgmeyer
Jeffrey Lopez-Rojas
Syed Ahsan Raza
Nicola Brice
Torben J. Hausrat
Tamar Macharadze
Silvia Diaz-Gonzalez
Mark Carlton
Antonio Virgilio Failla
Oliver Stork
Michaela Schweizer
Eckart D. Gundelfinger
Matthias Kneussel
Christina Spilker
Anna Karpova
Michael R. Kreutz
author_facet Maria Andres-Alonso
Mohamed Raafet Ammar
Ioana Butnaru
Guilherme M. Gomes
Gustavo Acuña Sanhueza
Rajeev Raman
PingAn Yuanxiang
Maximilian Borgmeyer
Jeffrey Lopez-Rojas
Syed Ahsan Raza
Nicola Brice
Torben J. Hausrat
Tamar Macharadze
Silvia Diaz-Gonzalez
Mark Carlton
Antonio Virgilio Failla
Oliver Stork
Michaela Schweizer
Eckart D. Gundelfinger
Matthias Kneussel
Christina Spilker
Anna Karpova
Michael R. Kreutz
author_sort Maria Andres-Alonso
title SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
title_short SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
title_full SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
title_fullStr SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
title_full_unstemmed SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals
title_sort sipa1l2 controls trafficking and local signaling of trkb-containing amphisomes at presynaptic terminals
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/8405b7ea05e8461086f8fdd56ee7dec8
work_keys_str_mv AT mariaandresalonso sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT mohamedraafetammar sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT ioanabutnaru sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT guilhermemgomes sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT gustavoacunasanhueza sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT rajeevraman sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT pinganyuanxiang sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT maximilianborgmeyer sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT jeffreylopezrojas sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT syedahsanraza sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT nicolabrice sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT torbenjhausrat sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT tamarmacharadze sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT silviadiazgonzalez sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT markcarlton sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT antoniovirgiliofailla sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT oliverstork sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT michaelaschweizer sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT eckartdgundelfinger sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT matthiaskneussel sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT christinaspilker sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT annakarpova sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
AT michaelrkreutz sipa1l2controlstraffickingandlocalsignalingoftrkbcontainingamphisomesatpresynapticterminals
_version_ 1718382509931102208