Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography

C Lommatzsch,1 K Rothaus,1 JM Koch,1 C Heinz,1,2 S Grisanti3 1Department of Ophthalmology, St. Franziskus Hospital, Muenster 48145, Germany; 2Department of Ophthalmology, University of Essen, Essen, Germany; 3Department of Ophthalmology, University of Luebeck, Luebeck, GermanyCorrespondence: C Lomma...

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Autores principales:	Lommatzsch C, Rothaus K, Koch JM, Heinz C, Grisanti S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	oct angiography glaucoma entities blood flow vessel density Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8405c4ebcf9c4c3fa197f23cda898fee
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spelling	oai:doaj.org-article:8405c4ebcf9c4c3fa197f23cda898fee2021-12-02T10:06:17ZVessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography1177-5483https://doaj.org/article/8405c4ebcf9c4c3fa197f23cda898fee2019-12-01T00:00:00Zhttps://www.dovepress.com/vessel-density-in-glaucoma-of-different-entities-as-measured-with-opti-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483C Lommatzsch,1 K Rothaus,1 JM Koch,1 C Heinz,1,2 S Grisanti3 1Department of Ophthalmology, St. Franziskus Hospital, Muenster 48145, Germany; 2Department of Ophthalmology, University of Essen, Essen, Germany; 3Department of Ophthalmology, University of Luebeck, Luebeck, GermanyCorrespondence: C LommatzschDepartment of Ophthalmology, St. Franziskus Hospital, Hohenzollernring 74, Muenster 48145, GermanyTel +49 2519352711Fax +49 2519352719Email claudia.lommatzsch@augen-franziskus.dePurpose: To compare papillary and macular vessel density (VD), as measured by optical coherence tomography angiography (OCTA), in eyes with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) and exfoliation glaucoma (XFG).Methods: The papillary and macular VD of 40 eyes with POAG, 19 with NTG and 21 with XFG were examined using OCTA (AngioVue™). The VD was measured at two different layers of segmentation (optic nerve head: radial peripapillary capillary [RPC] and nerve head [NH]; macula: superficial [SL] and deep [DL] retinal vascular plexus) with a 4.5×4.5mm papillary and 6×6-mm macular scan. VD was calculated by an automated density measuring tool in the AngioVue™ software.Results: There were no significant differences in the total value of the papillary, peripapillary and macular VD. A significantly higher VD could be measured for NTG compared to POAG, as well as for XFG in the inferior nasal peripapillary sector at RPC-segmentation and at the NH-level between NDG and XFG.Conclusion: OCTA can detect a difference in VD in the nasal inferior peripapillary sector in NTG compared with POAG and XFG. These findings may help to improve the understanding of further pathophysiological mechanisms.Keywords: OCT angiography, glaucoma entities, blood flow, vessel densityLommatzsch CRothaus KKoch JMHeinz CGrisanti SDove Medical Pressarticleoct angiographyglaucoma entitiesblood flowvessel densityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2527-2534 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	oct angiography glaucoma entities blood flow vessel density Ophthalmology RE1-994
spellingShingle	oct angiography glaucoma entities blood flow vessel density Ophthalmology RE1-994 Lommatzsch C Rothaus K Koch JM Heinz C Grisanti S Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography
description	C Lommatzsch,1 K Rothaus,1 JM Koch,1 C Heinz,1,2 S Grisanti3 1Department of Ophthalmology, St. Franziskus Hospital, Muenster 48145, Germany; 2Department of Ophthalmology, University of Essen, Essen, Germany; 3Department of Ophthalmology, University of Luebeck, Luebeck, GermanyCorrespondence: C LommatzschDepartment of Ophthalmology, St. Franziskus Hospital, Hohenzollernring 74, Muenster 48145, GermanyTel +49 2519352711Fax +49 2519352719Email claudia.lommatzsch@augen-franziskus.dePurpose: To compare papillary and macular vessel density (VD), as measured by optical coherence tomography angiography (OCTA), in eyes with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) and exfoliation glaucoma (XFG).Methods: The papillary and macular VD of 40 eyes with POAG, 19 with NTG and 21 with XFG were examined using OCTA (AngioVue™). The VD was measured at two different layers of segmentation (optic nerve head: radial peripapillary capillary [RPC] and nerve head [NH]; macula: superficial [SL] and deep [DL] retinal vascular plexus) with a 4.5×4.5mm papillary and 6×6-mm macular scan. VD was calculated by an automated density measuring tool in the AngioVue™ software.Results: There were no significant differences in the total value of the papillary, peripapillary and macular VD. A significantly higher VD could be measured for NTG compared to POAG, as well as for XFG in the inferior nasal peripapillary sector at RPC-segmentation and at the NH-level between NDG and XFG.Conclusion: OCTA can detect a difference in VD in the nasal inferior peripapillary sector in NTG compared with POAG and XFG. These findings may help to improve the understanding of further pathophysiological mechanisms.Keywords: OCT angiography, glaucoma entities, blood flow, vessel density
format	article
author	Lommatzsch C Rothaus K Koch JM Heinz C Grisanti S
author_facet	Lommatzsch C Rothaus K Koch JM Heinz C Grisanti S
author_sort	Lommatzsch C
title	Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography
title_short	Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography
title_full	Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography
title_fullStr	Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography
title_full_unstemmed	Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography
title_sort	vessel density in glaucoma of different entities as measured with optical coherence tomography angiography
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/8405c4ebcf9c4c3fa197f23cda898fee
work_keys_str_mv	AT lommatzschc vesseldensityinglaucomaofdifferententitiesasmeasuredwithopticalcoherencetomographyangiography AT rothausk vesseldensityinglaucomaofdifferententitiesasmeasuredwithopticalcoherencetomographyangiography AT kochjm vesseldensityinglaucomaofdifferententitiesasmeasuredwithopticalcoherencetomographyangiography AT heinzc vesseldensityinglaucomaofdifferententitiesasmeasuredwithopticalcoherencetomographyangiography AT grisantis vesseldensityinglaucomaofdifferententitiesasmeasuredwithopticalcoherencetomographyangiography
_version_	1718397644070453248

Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography

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