White donor, younger donor and double lung transplant are associated with better survival in sarcoidosis patients

Abstract Sarcoidosis commonly affects the lung. Lung transplantation (LT) is required when there is a severe and refractory involvement. We compared post-transplant survival rates of sarcoidosis patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). We al...

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Autores principales:	Oriana Salamo, Shiva Roghaee, Michael D. Schweitzer, Alejandro Mantero, Shirin Shafazand, Michael Campos, Mehdi Mirsaeidi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/840712cbf1f34d90ae293ff04711bb4b
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spelling	oai:doaj.org-article:840712cbf1f34d90ae293ff04711bb4b2021-12-02T15:07:45ZWhite donor, younger donor and double lung transplant are associated with better survival in sarcoidosis patients10.1038/s41598-018-25144-x2045-2322https://doaj.org/article/840712cbf1f34d90ae293ff04711bb4b2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25144-xhttps://doaj.org/toc/2045-2322Abstract Sarcoidosis commonly affects the lung. Lung transplantation (LT) is required when there is a severe and refractory involvement. We compared post-transplant survival rates of sarcoidosis patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). We also explored whether the race and age of the donor, and double lung transplant have any effect on the survival in the post transplant setting. We analyzed 9,727 adult patients with sarcoidosis, COPD, and IPF who underwent LT worldwide between 2005–2015 based on United Network for Organ Sharing (UNOS) database. Survival rates were compared with Kaplan-Meier, and risk factors were investigated by Cox-regression analysis. 469 (5%) were transplanted because of sarcoidosis, 3,688 (38%) for COPD and 5,570 (57%) for IPF. Unadjusted survival analysis showed a better post-transplant survival rate for patients with sarcoidosis (p < 0.001, Log-rank test). In Cox-regression analysis, double lung transplant and white race of the lung donor showed to have a significant survival advantage. Since double lung transplant, those who are younger and have lower Lung Allocation Score (LAS) at the time of transplant have a survival advantage, we suggest double lung transplant as the procedure of choice, especially in younger sarcoidosis subjects and with lower LAS scores.Oriana SalamoShiva RoghaeeMichael D. SchweitzerAlejandro ManteroShirin ShafazandMichael CamposMehdi MirsaeidiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Oriana Salamo Shiva Roghaee Michael D. Schweitzer Alejandro Mantero Shirin Shafazand Michael Campos Mehdi Mirsaeidi White donor, younger donor and double lung transplant are associated with better survival in sarcoidosis patients
description	Abstract Sarcoidosis commonly affects the lung. Lung transplantation (LT) is required when there is a severe and refractory involvement. We compared post-transplant survival rates of sarcoidosis patients with chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). We also explored whether the race and age of the donor, and double lung transplant have any effect on the survival in the post transplant setting. We analyzed 9,727 adult patients with sarcoidosis, COPD, and IPF who underwent LT worldwide between 2005–2015 based on United Network for Organ Sharing (UNOS) database. Survival rates were compared with Kaplan-Meier, and risk factors were investigated by Cox-regression analysis. 469 (5%) were transplanted because of sarcoidosis, 3,688 (38%) for COPD and 5,570 (57%) for IPF. Unadjusted survival analysis showed a better post-transplant survival rate for patients with sarcoidosis (p < 0.001, Log-rank test). In Cox-regression analysis, double lung transplant and white race of the lung donor showed to have a significant survival advantage. Since double lung transplant, those who are younger and have lower Lung Allocation Score (LAS) at the time of transplant have a survival advantage, we suggest double lung transplant as the procedure of choice, especially in younger sarcoidosis subjects and with lower LAS scores.
format	article
author	Oriana Salamo Shiva Roghaee Michael D. Schweitzer Alejandro Mantero Shirin Shafazand Michael Campos Mehdi Mirsaeidi
author_facet	Oriana Salamo Shiva Roghaee Michael D. Schweitzer Alejandro Mantero Shirin Shafazand Michael Campos Mehdi Mirsaeidi
author_sort	Oriana Salamo
title	White donor, younger donor and double lung transplant are associated with better survival in sarcoidosis patients
title_short	White donor, younger donor and double lung transplant are associated with better survival in sarcoidosis patients
title_full	White donor, younger donor and double lung transplant are associated with better survival in sarcoidosis patients
title_fullStr	White donor, younger donor and double lung transplant are associated with better survival in sarcoidosis patients
title_full_unstemmed	White donor, younger donor and double lung transplant are associated with better survival in sarcoidosis patients
title_sort	white donor, younger donor and double lung transplant are associated with better survival in sarcoidosis patients
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/840712cbf1f34d90ae293ff04711bb4b
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White donor, younger donor and double lung transplant are associated with better survival in sarcoidosis patients

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