Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).

The major histocompatibility complex (MHC) is an important gene complex contributing to adaptive immunity. Studies of platyrrhine MHC have focused on identifying experimental models of immune system function in the equivalent Human Leukocyte Antigen (HLA). These genes have thus been explored primari...

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Autores principales:	Janet C Buckner, Katharine M Jack, Amanda D Melin, Valérie A M Schoof, Gustavo A Gutiérrez-Espeleta, Marcela G M Lima, Jessica W Lynch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/840763d63d174c0ba9cee58333ab4fb9
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spelling	oai:doaj.org-article:840763d63d174c0ba9cee58333ab4fb92021-12-02T20:18:19ZMajor histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).1932-620310.1371/journal.pone.0254604https://doaj.org/article/840763d63d174c0ba9cee58333ab4fb92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254604https://doaj.org/toc/1932-6203The major histocompatibility complex (MHC) is an important gene complex contributing to adaptive immunity. Studies of platyrrhine MHC have focused on identifying experimental models of immune system function in the equivalent Human Leukocyte Antigen (HLA). These genes have thus been explored primarily in captive platyrrhine individuals from research colonies. However, investigations of standing MHC variation and evolution in wild populations are essential to understanding its role in immunity, sociality and ecology. Capuchins are a promising model group exhibiting the greatest habitat diversity, widest diet breadth and arguably the most social complexity among platyrrhines, together likely resulting in varied immunological challenges. We use high-throughput sequencing to characterize polymorphism in four Class II DR and DQ exons for the first time in seven capuchin species. We find evidence for at least three copies for DQ genes and at least five for DRB, with possible additional unrecovered diversity. Our data also reveal common genotypes that are inherited across our most widely sampled population, Cebus imitator in Sector Santa Rosa, Costa Rica. Notably, phylogenetic analyses reveal that platyrrhine DQA sequences form a monophyletic group to the exclusion of all Catarrhini sequences examined. This result is inconsistent with the trans-species hypothesis for MHC evolution across infraorders in Primates and provides further evidence for the independent origin of current MHC genetic diversity in Platyrrhini. Identical allele sharing across cebid species, and more rarely genera, however, does underscore the complexity of MHC gene evolution and the need for more comprehensive assessments of allelic diversity and genome structure.Janet C BucknerKatharine M JackAmanda D MelinValérie A M SchoofGustavo A Gutiérrez-EspeletaMarcela G M LimaJessica W LynchPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0254604 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Janet C Buckner Katharine M Jack Amanda D Melin Valérie A M Schoof Gustavo A Gutiérrez-Espeleta Marcela G M Lima Jessica W Lynch Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).
description	The major histocompatibility complex (MHC) is an important gene complex contributing to adaptive immunity. Studies of platyrrhine MHC have focused on identifying experimental models of immune system function in the equivalent Human Leukocyte Antigen (HLA). These genes have thus been explored primarily in captive platyrrhine individuals from research colonies. However, investigations of standing MHC variation and evolution in wild populations are essential to understanding its role in immunity, sociality and ecology. Capuchins are a promising model group exhibiting the greatest habitat diversity, widest diet breadth and arguably the most social complexity among platyrrhines, together likely resulting in varied immunological challenges. We use high-throughput sequencing to characterize polymorphism in four Class II DR and DQ exons for the first time in seven capuchin species. We find evidence for at least three copies for DQ genes and at least five for DRB, with possible additional unrecovered diversity. Our data also reveal common genotypes that are inherited across our most widely sampled population, Cebus imitator in Sector Santa Rosa, Costa Rica. Notably, phylogenetic analyses reveal that platyrrhine DQA sequences form a monophyletic group to the exclusion of all Catarrhini sequences examined. This result is inconsistent with the trans-species hypothesis for MHC evolution across infraorders in Primates and provides further evidence for the independent origin of current MHC genetic diversity in Platyrrhini. Identical allele sharing across cebid species, and more rarely genera, however, does underscore the complexity of MHC gene evolution and the need for more comprehensive assessments of allelic diversity and genome structure.
format	article
author	Janet C Buckner Katharine M Jack Amanda D Melin Valérie A M Schoof Gustavo A Gutiérrez-Espeleta Marcela G M Lima Jessica W Lynch
author_facet	Janet C Buckner Katharine M Jack Amanda D Melin Valérie A M Schoof Gustavo A Gutiérrez-Espeleta Marcela G M Lima Jessica W Lynch
author_sort	Janet C Buckner
title	Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).
title_short	Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).
title_full	Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).
title_fullStr	Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).
title_full_unstemmed	Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).
title_sort	major histocompatibility complex class ii dr and dq evolution and variation in wild capuchin monkey species (cebinae).
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/840763d63d174c0ba9cee58333ab4fb9
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Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).

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