Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract

Xiu-Li Lim,1,* Boon-Wee Teo,2,* Bee-Choo Tai,1 Tien Y Wong,3 Daniel P-K Ng1 1Department of Epidemiology and Public Health, 2Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, 3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapo...

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Autores principales:	Lim XL, Teo BW, Tai BC, Wong TY, Ng DP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8408e3f56dd54878a8f789648dee6986
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spelling	oai:doaj.org-article:8408e3f56dd54878a8f789648dee69862021-12-02T06:52:46ZPentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract1178-7007https://doaj.org/article/8408e3f56dd54878a8f789648dee69862012-06-01T00:00:00Zhttp://www.dovepress.com/pentosidine-levels-in-nonproteinuric-diabetes-associated-with-both-low-a10260https://doaj.org/toc/1178-7007Xiu-Li Lim,1,* Boon-Wee Teo,2,* Bee-Choo Tai,1 Tien Y Wong,3 Daniel P-K Ng1 1Department of Epidemiology and Public Health, 2Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, 3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore*Joint first authorsBackground: The main objective of this study was to investigate whether plasma pentosidine levels were associated with cataract and low estimated glomerular filtration rate (eGFR) in nonproteinuric type 2 diabetic patients.Methods: We characterized 888 nonproteinuric type 2 diabetic patients residing in Singapore according to their eGFR values. Proteinuria was excluded on the basis of multiple urinalyses. Patients with low renal function (cases, n = 125) and controls (n = 763) were defined as having eGFR &lt; and &ge;60 mL/min/1.73 m2, respectively. Pentosidine levels were measured by enzyme-linked immunosorbent assay. Multinomial logistic regression was used to test the association between plasma pentosidine levels and the joint phenotype of cataract and low eGFR.Results: Cases had higher triacylglycerol values, higher systolic blood pressure, and were more likely to be treated with two or more antihypertensive medications. In univariate analysis, cases were potentially more than twice as likely to have had a history of cataract compared with controls. This association persisted in multivariate analyses after adjusting for the significant covariates, hypertension and triacylglycerol, but was attenuated when age was included in the model. Plasma pentosidine levels were significantly higher in cases with low eGFR who also had a history of cataract. This association persisted in multivariate analyses that included the covariates, glycosylated hemoglobin, hypertension, and diabetic retinopathy, as well as age.Conclusion: Carbonyl stress, as reflected by pentosidine levels, is present in a subset of nonproteinuric diabetic patients. Clinically, this stress was associated with the joint presence of cataract and low eGFR.Keywords: advanced glycation endproducts, Chinese, normoalbuminuria, renal functionLim XLTeo BWTai BCWong TYNg DPDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2012, Iss default, Pp 155-164 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Lim XL Teo BW Tai BC Wong TY Ng DP Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract
description	Xiu-Li Lim,1,* Boon-Wee Teo,2,* Bee-Choo Tai,1 Tien Y Wong,3 Daniel P-K Ng1 1Department of Epidemiology and Public Health, 2Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, 3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore*Joint first authorsBackground: The main objective of this study was to investigate whether plasma pentosidine levels were associated with cataract and low estimated glomerular filtration rate (eGFR) in nonproteinuric type 2 diabetic patients.Methods: We characterized 888 nonproteinuric type 2 diabetic patients residing in Singapore according to their eGFR values. Proteinuria was excluded on the basis of multiple urinalyses. Patients with low renal function (cases, n = 125) and controls (n = 763) were defined as having eGFR &lt; and &ge;60 mL/min/1.73 m2, respectively. Pentosidine levels were measured by enzyme-linked immunosorbent assay. Multinomial logistic regression was used to test the association between plasma pentosidine levels and the joint phenotype of cataract and low eGFR.Results: Cases had higher triacylglycerol values, higher systolic blood pressure, and were more likely to be treated with two or more antihypertensive medications. In univariate analysis, cases were potentially more than twice as likely to have had a history of cataract compared with controls. This association persisted in multivariate analyses after adjusting for the significant covariates, hypertension and triacylglycerol, but was attenuated when age was included in the model. Plasma pentosidine levels were significantly higher in cases with low eGFR who also had a history of cataract. This association persisted in multivariate analyses that included the covariates, glycosylated hemoglobin, hypertension, and diabetic retinopathy, as well as age.Conclusion: Carbonyl stress, as reflected by pentosidine levels, is present in a subset of nonproteinuric diabetic patients. Clinically, this stress was associated with the joint presence of cataract and low eGFR.Keywords: advanced glycation endproducts, Chinese, normoalbuminuria, renal function
format	article
author	Lim XL Teo BW Tai BC Wong TY Ng DP
author_facet	Lim XL Teo BW Tai BC Wong TY Ng DP
author_sort	Lim XL
title	Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract
title_short	Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract
title_full	Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract
title_fullStr	Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract
title_full_unstemmed	Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract
title_sort	pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/8408e3f56dd54878a8f789648dee6986
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Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract

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