Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat Protein
ABSTRACT Nullbasic is a derivative of the HIV-1 transactivator of transcription (Tat) protein that strongly inhibits HIV-1 replication in lymphocytes. Here we show that lentiviral vectors that constitutively express a Nullbasic-ZsGreen1 (NB-ZSG1) fusion protein by the eEF1α promoter led to robust lo...
Saved in:
Main Authors: | Hongping Jin, Dongsheng Li, Haran Sivakumaran, Mary Lor, Lina Rustanti, Nicole Cloonan, Shivangi Wani, David Harrich |
---|---|
Format: | article |
Language: | EN |
Published: |
American Society for Microbiology
2016
|
Subjects: | |
Online Access: | https://doaj.org/article/84093b2e09a64b72a2773d3f66c2ba85 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Strong <italic toggle="yes">In Vivo</italic> Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant
by: Hongping Jin, et al.
Published: (2019) -
Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking.
by: Min-Hsuan Lin, et al.
Published: (2012) -
Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription
by: Guillaume Mousseau, et al.
Published: (2019) -
UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat
by: Taizhen Liang, et al.
Published: (2021) -
Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
by: Dongsheng Li, et al.
Published: (2021)