Role of prostate health index to predict Gleason score upgrading and high-risk prostate cancer in radical prostatectomy specimens

Abstract We evaluated the role of prostate health index (PHI) in predicting Gleason score (GS) upgrading in International Society of Urological Pathology Grade Group (ISUP GG) 1 & 2 prostate cancer (PCa) or adverse pathologic outcomes at radical prostatectomy (RP). A total of 300 patients with p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hwanik Kim, Gyoohwan Jung, Jin Hyuck Kim, Seok-Soo Byun, Sung Kyu Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/840a649f8dee4dbaa5b52e9fbc16dad4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:840a649f8dee4dbaa5b52e9fbc16dad4
record_format	dspace
spelling	oai:doaj.org-article:840a649f8dee4dbaa5b52e9fbc16dad42021-12-02T19:04:01ZRole of prostate health index to predict Gleason score upgrading and high-risk prostate cancer in radical prostatectomy specimens10.1038/s41598-021-96993-22045-2322https://doaj.org/article/840a649f8dee4dbaa5b52e9fbc16dad42021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96993-2https://doaj.org/toc/2045-2322Abstract We evaluated the role of prostate health index (PHI) in predicting Gleason score (GS) upgrading in International Society of Urological Pathology Grade Group (ISUP GG) 1 & 2 prostate cancer (PCa) or adverse pathologic outcomes at radical prostatectomy (RP). A total of 300 patients with prostate specific antigen ≥ 3 ng/mL, PHI and prostate biopsy (71 patients with RP included) were retrospectively included in the study. The primary study outcomes are PCa and clinically significant PCa (csPCa, defined as ISUP GG ≥ 2) diagnostic rate of PHI, and GS upgrading rate at RP specimen. The secondary outcomes are the comparison between GS upgrading and non-upgrading group, GS upgrading and high-risk PCa (ISUP GG ≥ 3 or ≥ pT3a) predictability of preoperative clinical factors. Overall, 139 (46.3%) and 92 (30.7%) were diagnosed with PCa and csPCa, respectively. GS upgrading rate was 34.3% in all patients with RP. Significant differences were shown in the total prostate volume (p = 0.047), the distribution of ISUP GG at biopsy (p = 0.001) and RP (p = 0.032), respectively. PHI values ≥ 55 [Odds ratio (OR): 3.64 (95% confidence interval (CI) = 1.05–12.68, p = 0.042] and presence of PI-RADS lesion ≥ 4 (OR: 7.03, 95% CI = 1.68–29.51, p = 0.018) were the significant predictors of GS upgrading in RP specimens (AUC = 0.737). PHI values ≥ 55 (OR: 9.05, 5% CI = 1.04–78.52, p = 0.046) is a significant factor for predicting adverse pathologic features in RP specimens (AUC = 0.781). PHI could predict GS upgrading in combination with PIRADS lesions ≥ 4 in ISUP GG 1 & 2. PHI alone could evaluate the possibility of high-risk PCa after surgery as well.Hwanik KimGyoohwan JungJin Hyuck KimSeok-Soo ByunSung Kyu HongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hwanik Kim Gyoohwan Jung Jin Hyuck Kim Seok-Soo Byun Sung Kyu Hong Role of prostate health index to predict Gleason score upgrading and high-risk prostate cancer in radical prostatectomy specimens
description	Abstract We evaluated the role of prostate health index (PHI) in predicting Gleason score (GS) upgrading in International Society of Urological Pathology Grade Group (ISUP GG) 1 & 2 prostate cancer (PCa) or adverse pathologic outcomes at radical prostatectomy (RP). A total of 300 patients with prostate specific antigen ≥ 3 ng/mL, PHI and prostate biopsy (71 patients with RP included) were retrospectively included in the study. The primary study outcomes are PCa and clinically significant PCa (csPCa, defined as ISUP GG ≥ 2) diagnostic rate of PHI, and GS upgrading rate at RP specimen. The secondary outcomes are the comparison between GS upgrading and non-upgrading group, GS upgrading and high-risk PCa (ISUP GG ≥ 3 or ≥ pT3a) predictability of preoperative clinical factors. Overall, 139 (46.3%) and 92 (30.7%) were diagnosed with PCa and csPCa, respectively. GS upgrading rate was 34.3% in all patients with RP. Significant differences were shown in the total prostate volume (p = 0.047), the distribution of ISUP GG at biopsy (p = 0.001) and RP (p = 0.032), respectively. PHI values ≥ 55 [Odds ratio (OR): 3.64 (95% confidence interval (CI) = 1.05–12.68, p = 0.042] and presence of PI-RADS lesion ≥ 4 (OR: 7.03, 95% CI = 1.68–29.51, p = 0.018) were the significant predictors of GS upgrading in RP specimens (AUC = 0.737). PHI values ≥ 55 (OR: 9.05, 5% CI = 1.04–78.52, p = 0.046) is a significant factor for predicting adverse pathologic features in RP specimens (AUC = 0.781). PHI could predict GS upgrading in combination with PIRADS lesions ≥ 4 in ISUP GG 1 & 2. PHI alone could evaluate the possibility of high-risk PCa after surgery as well.
format	article
author	Hwanik Kim Gyoohwan Jung Jin Hyuck Kim Seok-Soo Byun Sung Kyu Hong
author_facet	Hwanik Kim Gyoohwan Jung Jin Hyuck Kim Seok-Soo Byun Sung Kyu Hong
author_sort	Hwanik Kim
title	Role of prostate health index to predict Gleason score upgrading and high-risk prostate cancer in radical prostatectomy specimens
title_short	Role of prostate health index to predict Gleason score upgrading and high-risk prostate cancer in radical prostatectomy specimens
title_full	Role of prostate health index to predict Gleason score upgrading and high-risk prostate cancer in radical prostatectomy specimens
title_fullStr	Role of prostate health index to predict Gleason score upgrading and high-risk prostate cancer in radical prostatectomy specimens
title_full_unstemmed	Role of prostate health index to predict Gleason score upgrading and high-risk prostate cancer in radical prostatectomy specimens
title_sort	role of prostate health index to predict gleason score upgrading and high-risk prostate cancer in radical prostatectomy specimens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/840a649f8dee4dbaa5b52e9fbc16dad4
work_keys_str_mv	AT hwanikkim roleofprostatehealthindextopredictgleasonscoreupgradingandhighriskprostatecancerinradicalprostatectomyspecimens AT gyoohwanjung roleofprostatehealthindextopredictgleasonscoreupgradingandhighriskprostatecancerinradicalprostatectomyspecimens AT jinhyuckkim roleofprostatehealthindextopredictgleasonscoreupgradingandhighriskprostatecancerinradicalprostatectomyspecimens AT seoksoobyun roleofprostatehealthindextopredictgleasonscoreupgradingandhighriskprostatecancerinradicalprostatectomyspecimens AT sungkyuhong roleofprostatehealthindextopredictgleasonscoreupgradingandhighriskprostatecancerinradicalprostatectomyspecimens
_version_	1718377220678877184

Role of prostate health index to predict Gleason score upgrading and high-risk prostate cancer in radical prostatectomy specimens

Ejemplares similares