Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection

Strategies to improve the function of damaged hearts with progenitor cells have stalled. Here, the authors show that gene transfer of a calcium-dependent potassium channel enhances the functional properties and ability of explant-derived cells to improve heart function after a heart attack.

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Autores principales:	Patrick Vigneault, Sandrine Parent, Pushpinder Kanda, Connor Michie, Darryl R. Davis, Stanley Nattel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/840a9115e7784df6b8daa2ba58242d52
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spelling	oai:doaj.org-article:840a9115e7784df6b8daa2ba58242d522021-12-02T15:10:40ZElectrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection10.1038/s41467-021-25180-82041-1723https://doaj.org/article/840a9115e7784df6b8daa2ba58242d522021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25180-8https://doaj.org/toc/2041-1723Strategies to improve the function of damaged hearts with progenitor cells have stalled. Here, the authors show that gene transfer of a calcium-dependent potassium channel enhances the functional properties and ability of explant-derived cells to improve heart function after a heart attack.Patrick VigneaultSandrine ParentPushpinder KandaConnor MichieDarryl R. DavisStanley NattelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patrick Vigneault Sandrine Parent Pushpinder Kanda Connor Michie Darryl R. Davis Stanley Nattel Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
description	Strategies to improve the function of damaged hearts with progenitor cells have stalled. Here, the authors show that gene transfer of a calcium-dependent potassium channel enhances the functional properties and ability of explant-derived cells to improve heart function after a heart attack.
format	article
author	Patrick Vigneault Sandrine Parent Pushpinder Kanda Connor Michie Darryl R. Davis Stanley Nattel
author_facet	Patrick Vigneault Sandrine Parent Pushpinder Kanda Connor Michie Darryl R. Davis Stanley Nattel
author_sort	Patrick Vigneault
title	Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
title_short	Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
title_full	Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
title_fullStr	Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
title_full_unstemmed	Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
title_sort	electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/840a9115e7784df6b8daa2ba58242d52
work_keys_str_mv	AT patrickvigneault electrophysiologicalengineeringofheartderivedcellswithcalciumdependentpotassiumchannelsimprovescelltherapyefficacyforcardioprotection AT sandrineparent electrophysiologicalengineeringofheartderivedcellswithcalciumdependentpotassiumchannelsimprovescelltherapyefficacyforcardioprotection AT pushpinderkanda electrophysiologicalengineeringofheartderivedcellswithcalciumdependentpotassiumchannelsimprovescelltherapyefficacyforcardioprotection AT connormichie electrophysiologicalengineeringofheartderivedcellswithcalciumdependentpotassiumchannelsimprovescelltherapyefficacyforcardioprotection AT darrylrdavis electrophysiologicalengineeringofheartderivedcellswithcalciumdependentpotassiumchannelsimprovescelltherapyefficacyforcardioprotection AT stanleynattel electrophysiologicalengineeringofheartderivedcellswithcalciumdependentpotassiumchannelsimprovescelltherapyefficacyforcardioprotection
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Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection

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