Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors

Targeting tumor-associated antigens in paediatric medulloblastomas (MB) is challenging due to their low mutational burden. Here, the authors develop a sensitive proteogenomic approach to identify tumour specific neoantigens, which may enable personalised T cell immunotherapy in paediatric MB.

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Autores principales:	Samuel Rivero-Hinojosa, Melanie Grant, Aswini Panigrahi, Huizhen Zhang, Veronika Caisova, Catherine M. Bollard, Brian R. Rood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/840da9f71cf2490ba9c63c3c085c7058
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spelling	oai:doaj.org-article:840da9f71cf2490ba9c63c3c085c70582021-11-21T12:35:13ZProteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors10.1038/s41467-021-26936-y2041-1723https://doaj.org/article/840da9f71cf2490ba9c63c3c085c70582021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26936-yhttps://doaj.org/toc/2041-1723Targeting tumor-associated antigens in paediatric medulloblastomas (MB) is challenging due to their low mutational burden. Here, the authors develop a sensitive proteogenomic approach to identify tumour specific neoantigens, which may enable personalised T cell immunotherapy in paediatric MB.Samuel Rivero-HinojosaMelanie GrantAswini PanigrahiHuizhen ZhangVeronika CaisovaCatherine M. BollardBrian R. RoodNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samuel Rivero-Hinojosa Melanie Grant Aswini Panigrahi Huizhen Zhang Veronika Caisova Catherine M. Bollard Brian R. Rood Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors
description	Targeting tumor-associated antigens in paediatric medulloblastomas (MB) is challenging due to their low mutational burden. Here, the authors develop a sensitive proteogenomic approach to identify tumour specific neoantigens, which may enable personalised T cell immunotherapy in paediatric MB.
format	article
author	Samuel Rivero-Hinojosa Melanie Grant Aswini Panigrahi Huizhen Zhang Veronika Caisova Catherine M. Bollard Brian R. Rood
author_facet	Samuel Rivero-Hinojosa Melanie Grant Aswini Panigrahi Huizhen Zhang Veronika Caisova Catherine M. Bollard Brian R. Rood
author_sort	Samuel Rivero-Hinojosa
title	Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors
title_short	Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors
title_full	Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors
title_fullStr	Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors
title_full_unstemmed	Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors
title_sort	proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted t cell immunotherapy for brain tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/840da9f71cf2490ba9c63c3c085c7058
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Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors

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