Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance

Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance

The molecular mechanisms underlying cancer cell radioresistance need to be elucidated. In this study, the authors show that the microRNA biogenesis factor DGCR8 is stabilized by USP51 and ATM upon irradiation and by consequence it promotes the repair of DNA double-strand breaks and radioresistance b...

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Autores principales: Qinglei Hang, Liyong Zeng, Li Wang, Litong Nie, Fan Yao, Hongqi Teng, Yalan Deng, Shannon Yap, Yutong Sun, Steven J. Frank, Junjie Chen, Li Ma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/840fee3496b548828dc6ab49a766f66c
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spelling oai:doaj.org-article:840fee3496b548828dc6ab49a766f66c2021-12-02T16:10:52ZNon-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance10.1038/s41467-021-24298-z2041-1723https://doaj.org/article/840fee3496b548828dc6ab49a766f66c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24298-zhttps://doaj.org/toc/2041-1723The molecular mechanisms underlying cancer cell radioresistance need to be elucidated. In this study, the authors show that the microRNA biogenesis factor DGCR8 is stabilized by USP51 and ATM upon irradiation and by consequence it promotes the repair of DNA double-strand breaks and radioresistance by recruiting RNF168 to sites of damage.Qinglei HangLiyong ZengLi WangLitong NieFan YaoHongqi TengYalan DengShannon YapYutong SunSteven J. FrankJunjie ChenLi MaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qinglei Hang
Liyong Zeng
Li Wang
Litong Nie
Fan Yao
Hongqi Teng
Yalan Deng
Shannon Yap
Yutong Sun
Steven J. Frank
Junjie Chen
Li Ma
Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance
description The molecular mechanisms underlying cancer cell radioresistance need to be elucidated. In this study, the authors show that the microRNA biogenesis factor DGCR8 is stabilized by USP51 and ATM upon irradiation and by consequence it promotes the repair of DNA double-strand breaks and radioresistance by recruiting RNF168 to sites of damage.
format article
author Qinglei Hang
Liyong Zeng
Li Wang
Litong Nie
Fan Yao
Hongqi Teng
Yalan Deng
Shannon Yap
Yutong Sun
Steven J. Frank
Junjie Chen
Li Ma
author_facet Qinglei Hang
Liyong Zeng
Li Wang
Litong Nie
Fan Yao
Hongqi Teng
Yalan Deng
Shannon Yap
Yutong Sun
Steven J. Frank
Junjie Chen
Li Ma
author_sort Qinglei Hang
title Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance
title_short Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance
title_full Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance
title_fullStr Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance
title_full_unstemmed Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance
title_sort non-canonical function of dgcr8 in dna double-strand break repair signaling and tumor radioresistance
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/840fee3496b548828dc6ab49a766f66c
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