Expression of P53 and P63 in Oral Lichen Planus and Oral Lichenoid Lesions

BACKGROUND AND OBJECTIVE: A few samples of oral lichen planus and lichenoid reactions may be change to malignancy. Histopathological diagnosis is a tool for diagnosis but it is not correct for segregation of these lesions. The aim of this survey was to examine immunohistochemistry expression of P53...

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Autores principales:	M Seyedmajidi, SH Shafaee, M Hejazi, M Haji Ahmadi, S Siadati
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	lichen planus oral lichenoid lesions p53 p63 immunohistochemistry Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/841251dae8854d0da1ddc59f63765f5b
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spelling	oai:doaj.org-article:841251dae8854d0da1ddc59f63765f5b2021-11-10T08:56:42ZExpression of P53 and P63 in Oral Lichen Planus and Oral Lichenoid Lesions1561-41072251-7170https://doaj.org/article/841251dae8854d0da1ddc59f63765f5b2011-07-01T00:00:00Zhttp://jbums.org/article-1-3835-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: A few samples of oral lichen planus and lichenoid reactions may be change to malignancy. Histopathological diagnosis is a tool for diagnosis but it is not correct for segregation of these lesions. The aim of this survey was to examine immunohistochemistry expression of P53 and P63 in oral lichen planus and oral lichenoid lesions according to different aetiopathogenesis, clinical behavior and neoplastic changes of these diseases.METHODS: The cross sectional study was done on 80 cases (40 cases of oral lichen planus and 40 cases of oral lichenoid lesions) gotten from pathology department of Babol dental faculty and Shahid Beheshti hospital. Slices gotten from paraffined block stained by P63 and P53 antibody, using immunohistochemical procedure. The percent of stained cells in basal layer, suprabasal layers and inflammatory inflammation was graded. when none of cells were stained (-) the stained cells were included < 10% of the total cell population (+) when the stained cells were included from 10% to 25% of the total cell population (++) when the stained cells were included from 26% to 50% of the total cell population (+++) and (++++) for the stained cells were accounted >50%. The obtained results were assessed and compared.FINDINGS: The expression of P53 in oral lichen planus was more than oral lichenoid lesions, (p0.05). The expression of P53 in oral lichen planus and lichenoid lesions, in basal layer was more than suprabasal layer and inflammatory infiltration and in suprabasal layer was more than inflammatory infiltration. The same result gotten about P63 expression (p<0.05). The rate of P53 in oral lichen planus, in basal layer (p=0.012) suprabasal layers (p<0.0001) and inflammatory infiltration (p=0.003), was more than oral lichenoid lesions, but there was not significant statistical relation between oral lichen planus and oral lichenoid lesions in expression of P63 in basal layer, suprabasal layer and inflammatory infiltration.CONCLUSION: The results showed the coordination activity of P63 and P53 proteins to protect oral mucosa from harmful effects of inflammation.M SeyedmajidiSH ShafaeeM HejaziM Haji AhmadiS SiadatiBabol University of Medical Sciencesarticlelichen planusoral lichenoid lesionsp53p63immunohistochemistryMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 4, Pp 7-13 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	lichen planus oral lichenoid lesions p53 p63 immunohistochemistry Medicine R Medicine (General) R5-920
spellingShingle	lichen planus oral lichenoid lesions p53 p63 immunohistochemistry Medicine R Medicine (General) R5-920 M Seyedmajidi SH Shafaee M Hejazi M Haji Ahmadi S Siadati Expression of P53 and P63 in Oral Lichen Planus and Oral Lichenoid Lesions
description	BACKGROUND AND OBJECTIVE: A few samples of oral lichen planus and lichenoid reactions may be change to malignancy. Histopathological diagnosis is a tool for diagnosis but it is not correct for segregation of these lesions. The aim of this survey was to examine immunohistochemistry expression of P53 and P63 in oral lichen planus and oral lichenoid lesions according to different aetiopathogenesis, clinical behavior and neoplastic changes of these diseases.METHODS: The cross sectional study was done on 80 cases (40 cases of oral lichen planus and 40 cases of oral lichenoid lesions) gotten from pathology department of Babol dental faculty and Shahid Beheshti hospital. Slices gotten from paraffined block stained by P63 and P53 antibody, using immunohistochemical procedure. The percent of stained cells in basal layer, suprabasal layers and inflammatory inflammation was graded. when none of cells were stained (-) the stained cells were included < 10% of the total cell population (+) when the stained cells were included from 10% to 25% of the total cell population (++) when the stained cells were included from 26% to 50% of the total cell population (+++) and (++++) for the stained cells were accounted >50%. The obtained results were assessed and compared.FINDINGS: The expression of P53 in oral lichen planus was more than oral lichenoid lesions, (p0.05). The expression of P53 in oral lichen planus and lichenoid lesions, in basal layer was more than suprabasal layer and inflammatory infiltration and in suprabasal layer was more than inflammatory infiltration. The same result gotten about P63 expression (p<0.05). The rate of P53 in oral lichen planus, in basal layer (p=0.012) suprabasal layers (p<0.0001) and inflammatory infiltration (p=0.003), was more than oral lichenoid lesions, but there was not significant statistical relation between oral lichen planus and oral lichenoid lesions in expression of P63 in basal layer, suprabasal layer and inflammatory infiltration.CONCLUSION: The results showed the coordination activity of P63 and P53 proteins to protect oral mucosa from harmful effects of inflammation.
format	article
author	M Seyedmajidi SH Shafaee M Hejazi M Haji Ahmadi S Siadati
author_facet	M Seyedmajidi SH Shafaee M Hejazi M Haji Ahmadi S Siadati
author_sort	M Seyedmajidi
title	Expression of P53 and P63 in Oral Lichen Planus and Oral Lichenoid Lesions
title_short	Expression of P53 and P63 in Oral Lichen Planus and Oral Lichenoid Lesions
title_full	Expression of P53 and P63 in Oral Lichen Planus and Oral Lichenoid Lesions
title_fullStr	Expression of P53 and P63 in Oral Lichen Planus and Oral Lichenoid Lesions
title_full_unstemmed	Expression of P53 and P63 in Oral Lichen Planus and Oral Lichenoid Lesions
title_sort	expression of p53 and p63 in oral lichen planus and oral lichenoid lesions
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/841251dae8854d0da1ddc59f63765f5b
work_keys_str_mv	AT mseyedmajidi expressionofp53andp63inorallichenplanusandorallichenoidlesions AT shshafaee expressionofp53andp63inorallichenplanusandorallichenoidlesions AT mhejazi expressionofp53andp63inorallichenplanusandorallichenoidlesions AT mhajiahmadi expressionofp53andp63inorallichenplanusandorallichenoidlesions AT ssiadati expressionofp53andp63inorallichenplanusandorallichenoidlesions
_version_	1718440301744357376

Expression of P53 and P63 in Oral Lichen Planus and Oral Lichenoid Lesions

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