Comprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma

Enhancer RNAs (eRNAs), a subclass of noncoding RNAs from enhancers, have been demonstrated to exhibit important regulatory effects on the expressions of various genes. However, the role of eRNAs in skin cutaneous melanoma (SKCM) remained largely unclear. In this study, we aimed to explore the expres...

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Autores principales:	Zhi-yong Chen, Jie-qing Huang, Yu Zhu, Yong-song Chen, Xue-feng Yu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8416dbdd30964ec7840105c976f23165
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spelling	oai:doaj.org-article:8416dbdd30964ec7840105c976f231652021-11-22T01:11:17ZComprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma1875-863010.1155/2021/2409820https://doaj.org/article/8416dbdd30964ec7840105c976f231652021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2409820https://doaj.org/toc/1875-8630Enhancer RNAs (eRNAs), a subclass of noncoding RNAs from enhancers, have been demonstrated to exhibit important regulatory effects on the expressions of various genes. However, the role of eRNAs in skin cutaneous melanoma (SKCM) remained largely unclear. In this study, we aimed to explore the expression and prognostic value of an enhancer RNA TEX41 in SKCM as well as the associations between TEX41 and tumor-infiltrating immune cells (TICs). We observed that TEX41 expression was distinctly increased in SKCM specimens compared with normal skin specimens using GEPIA. Survival assays based on TGCA datasets revealed that patients with low TEX41 expressions displayed a longer overall survival than those with high TEX41 expression. CIBERSORT datasets revealed that TEX41 was related to 8 types of TICs (macrophages M1, T cells regulatory, plasma cells, mast cells resting, T cells CD8, dendritic cells resting, and T cells follicular helper). Three kinds of TICs were negatively related to TEX41 expressions, including macrophages M2, NK cells resting, and macrophages M0. The expressions of TEX41 were involved in five KEGG pathways, including transcriptional misregulation in cancer, SNARE interactions in vesicular transport, mitophagy-animal, melanoma, melanogenesis, and progesterone-mediated oocyte maturation. Overall, TEX41 can be used as a novel biomarker for the prognosis of SKCM patients and is associated with TICs, indicating it as a therapeutic target for SKCM.Zhi-yong ChenJie-qing HuangYu ZhuYong-song ChenXue-feng YuHindawi LimitedarticleMedicine (General)R5-920ENDisease Markers, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhi-yong Chen Jie-qing Huang Yu Zhu Yong-song Chen Xue-feng Yu Comprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma
description	Enhancer RNAs (eRNAs), a subclass of noncoding RNAs from enhancers, have been demonstrated to exhibit important regulatory effects on the expressions of various genes. However, the role of eRNAs in skin cutaneous melanoma (SKCM) remained largely unclear. In this study, we aimed to explore the expression and prognostic value of an enhancer RNA TEX41 in SKCM as well as the associations between TEX41 and tumor-infiltrating immune cells (TICs). We observed that TEX41 expression was distinctly increased in SKCM specimens compared with normal skin specimens using GEPIA. Survival assays based on TGCA datasets revealed that patients with low TEX41 expressions displayed a longer overall survival than those with high TEX41 expression. CIBERSORT datasets revealed that TEX41 was related to 8 types of TICs (macrophages M1, T cells regulatory, plasma cells, mast cells resting, T cells CD8, dendritic cells resting, and T cells follicular helper). Three kinds of TICs were negatively related to TEX41 expressions, including macrophages M2, NK cells resting, and macrophages M0. The expressions of TEX41 were involved in five KEGG pathways, including transcriptional misregulation in cancer, SNARE interactions in vesicular transport, mitophagy-animal, melanoma, melanogenesis, and progesterone-mediated oocyte maturation. Overall, TEX41 can be used as a novel biomarker for the prognosis of SKCM patients and is associated with TICs, indicating it as a therapeutic target for SKCM.
format	article
author	Zhi-yong Chen Jie-qing Huang Yu Zhu Yong-song Chen Xue-feng Yu
author_facet	Zhi-yong Chen Jie-qing Huang Yu Zhu Yong-song Chen Xue-feng Yu
author_sort	Zhi-yong Chen
title	Comprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma
title_short	Comprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma
title_full	Comprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma
title_fullStr	Comprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma
title_full_unstemmed	Comprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma
title_sort	comprehensive analysis of the immune implication of tex41 in skin cutaneous melanoma
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/8416dbdd30964ec7840105c976f23165
work_keys_str_mv	AT zhiyongchen comprehensiveanalysisoftheimmuneimplicationoftex41inskincutaneousmelanoma AT jieqinghuang comprehensiveanalysisoftheimmuneimplicationoftex41inskincutaneousmelanoma AT yuzhu comprehensiveanalysisoftheimmuneimplicationoftex41inskincutaneousmelanoma AT yongsongchen comprehensiveanalysisoftheimmuneimplicationoftex41inskincutaneousmelanoma AT xuefengyu comprehensiveanalysisoftheimmuneimplicationoftex41inskincutaneousmelanoma
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Comprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma

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