Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum

Applying complexome profiling, Evers et al. unravel the composition of mitochondrial oxidative phosphorylation complexes in P. falciparum asexual and sexual blood stages. Abundance of these complexes differs between both stages, supporting the hypothesis that a mitochondrial metabolic switch is cent...

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Autores principales: Felix Evers, Alfredo Cabrera-Orefice, Dei M. Elurbe, Mariska Kea-te Lindert, Sylwia D. Boltryk, Till S. Voss, Martijn A. Huynen, Ulrich Brandt, Taco W. A. Kooij
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/84175595e535442092eacbb5b96bf88c
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Sumario:Applying complexome profiling, Evers et al. unravel the composition of mitochondrial oxidative phosphorylation complexes in P. falciparum asexual and sexual blood stages. Abundance of these complexes differs between both stages, supporting the hypothesis that a mitochondrial metabolic switch is central to gametocyte development and functioning.