Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reve...

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Autores principales: Joshua Moss, Judith Magenheim, Daniel Neiman, Hai Zemmour, Netanel Loyfer, Amit Korach, Yaacov Samet, Myriam Maoz, Henrik Druid, Peter Arner, Keng-Yeh Fu, Endre Kiss, Kirsty L. Spalding, Giora Landesberg, Aviad Zick, Albert Grinshpun, A. M. James Shapiro, Markus Grompe, Avigail Dreazan Wittenberg, Benjamin Glaser, Ruth Shemer, Tommy Kaplan, Yuval Dor
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/841a0167145749b69b07423fda860202
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spelling oai:doaj.org-article:841a0167145749b69b07423fda8602022021-12-02T17:32:16ZComprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease10.1038/s41467-018-07466-62041-1723https://doaj.org/article/841a0167145749b69b07423fda8602022018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07466-6https://doaj.org/toc/2041-1723The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reveals tissue contributions that agree with clinical findings.Joshua MossJudith MagenheimDaniel NeimanHai ZemmourNetanel LoyferAmit KorachYaacov SametMyriam MaozHenrik DruidPeter ArnerKeng-Yeh FuEndre KissKirsty L. SpaldingGiora LandesbergAviad ZickAlbert GrinshpunA. M. James ShapiroMarkus GrompeAvigail Dreazan WittenbergBenjamin GlaserRuth ShemerTommy KaplanYuval DorNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Joshua Moss
Judith Magenheim
Daniel Neiman
Hai Zemmour
Netanel Loyfer
Amit Korach
Yaacov Samet
Myriam Maoz
Henrik Druid
Peter Arner
Keng-Yeh Fu
Endre Kiss
Kirsty L. Spalding
Giora Landesberg
Aviad Zick
Albert Grinshpun
A. M. James Shapiro
Markus Grompe
Avigail Dreazan Wittenberg
Benjamin Glaser
Ruth Shemer
Tommy Kaplan
Yuval Dor
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
description The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reveals tissue contributions that agree with clinical findings.
format article
author Joshua Moss
Judith Magenheim
Daniel Neiman
Hai Zemmour
Netanel Loyfer
Amit Korach
Yaacov Samet
Myriam Maoz
Henrik Druid
Peter Arner
Keng-Yeh Fu
Endre Kiss
Kirsty L. Spalding
Giora Landesberg
Aviad Zick
Albert Grinshpun
A. M. James Shapiro
Markus Grompe
Avigail Dreazan Wittenberg
Benjamin Glaser
Ruth Shemer
Tommy Kaplan
Yuval Dor
author_facet Joshua Moss
Judith Magenheim
Daniel Neiman
Hai Zemmour
Netanel Loyfer
Amit Korach
Yaacov Samet
Myriam Maoz
Henrik Druid
Peter Arner
Keng-Yeh Fu
Endre Kiss
Kirsty L. Spalding
Giora Landesberg
Aviad Zick
Albert Grinshpun
A. M. James Shapiro
Markus Grompe
Avigail Dreazan Wittenberg
Benjamin Glaser
Ruth Shemer
Tommy Kaplan
Yuval Dor
author_sort Joshua Moss
title Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
title_short Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
title_full Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
title_fullStr Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
title_full_unstemmed Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
title_sort comprehensive human cell-type methylation atlas reveals origins of circulating cell-free dna in health and disease
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/841a0167145749b69b07423fda860202
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