Triglycerides and Open Angle Glaucoma – A Meta-analysis with meta-regression

Abstract Although intraocular pressure is the main the risk factor for the development of glaucoma, other risk factors such as vascular dysfunction might play an additional pathogenic role. Hypertriglyceridemia, which may lead to vascular dysfunction, has been implicated in the development of glauco...

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Autores principales:	Laura Pertl, Georg Mossböck, Andreas Wedrich, Martin Weger, Oliver Königsbrügge, Günther Silbernagel, Florian Posch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/841e471609f54c44a1cfe4b110f4de86
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spelling	oai:doaj.org-article:841e471609f54c44a1cfe4b110f4de862021-12-02T16:08:24ZTriglycerides and Open Angle Glaucoma – A Meta-analysis with meta-regression10.1038/s41598-017-08295-12045-2322https://doaj.org/article/841e471609f54c44a1cfe4b110f4de862017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08295-1https://doaj.org/toc/2045-2322Abstract Although intraocular pressure is the main the risk factor for the development of glaucoma, other risk factors such as vascular dysfunction might play an additional pathogenic role. Hypertriglyceridemia, which may lead to vascular dysfunction, has been implicated in the development of glaucoma. The objective of this meta-analysis was to investigate the association of triglyceride levels with the risk of glaucoma in case-control studies. Seventeen case-control studies were included investigating the difference in triglyceride levels in patients with glaucoma (N = 1 391) compared to subjects without glaucoma (N = 25 575). In random effects meta-analysis, the pooled mean triglyceride level across all studies and patients with and without glaucoma was 132.9 mg/dL (95%CI: 124.0–141.7). Patients with glaucoma had significantly higher mean triglyceride levels than patients without glaucoma (absolute difference = 14.2 mg/dL, 95%CI: 5.8–22.5, p < 0.0001). A considerable amount of heterogeneity of included studies was observed (I2 = 66.2%, heterogeneity χ2 = 47.4 on 16 degrees of freedom, p < 0.0001). In conclusion, this meta-analysis of case-control studies found that patients with glaucoma had higher mean triglyceride levels than patients without glaucoma. This finding is consistent with the concept that hypertriglyceridemia represents an additional risk factor for glaucoma. Whether this association is causal and/or might be modified by glaucoma medications remains to be investigated.Laura PertlGeorg MossböckAndreas WedrichMartin WegerOliver KönigsbrüggeGünther SilbernagelFlorian PoschNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laura Pertl Georg Mossböck Andreas Wedrich Martin Weger Oliver Königsbrügge Günther Silbernagel Florian Posch Triglycerides and Open Angle Glaucoma – A Meta-analysis with meta-regression
description	Abstract Although intraocular pressure is the main the risk factor for the development of glaucoma, other risk factors such as vascular dysfunction might play an additional pathogenic role. Hypertriglyceridemia, which may lead to vascular dysfunction, has been implicated in the development of glaucoma. The objective of this meta-analysis was to investigate the association of triglyceride levels with the risk of glaucoma in case-control studies. Seventeen case-control studies were included investigating the difference in triglyceride levels in patients with glaucoma (N = 1 391) compared to subjects without glaucoma (N = 25 575). In random effects meta-analysis, the pooled mean triglyceride level across all studies and patients with and without glaucoma was 132.9 mg/dL (95%CI: 124.0–141.7). Patients with glaucoma had significantly higher mean triglyceride levels than patients without glaucoma (absolute difference = 14.2 mg/dL, 95%CI: 5.8–22.5, p < 0.0001). A considerable amount of heterogeneity of included studies was observed (I2 = 66.2%, heterogeneity χ2 = 47.4 on 16 degrees of freedom, p < 0.0001). In conclusion, this meta-analysis of case-control studies found that patients with glaucoma had higher mean triglyceride levels than patients without glaucoma. This finding is consistent with the concept that hypertriglyceridemia represents an additional risk factor for glaucoma. Whether this association is causal and/or might be modified by glaucoma medications remains to be investigated.
format	article
author	Laura Pertl Georg Mossböck Andreas Wedrich Martin Weger Oliver Königsbrügge Günther Silbernagel Florian Posch
author_facet	Laura Pertl Georg Mossböck Andreas Wedrich Martin Weger Oliver Königsbrügge Günther Silbernagel Florian Posch
author_sort	Laura Pertl
title	Triglycerides and Open Angle Glaucoma – A Meta-analysis with meta-regression
title_short	Triglycerides and Open Angle Glaucoma – A Meta-analysis with meta-regression
title_full	Triglycerides and Open Angle Glaucoma – A Meta-analysis with meta-regression
title_fullStr	Triglycerides and Open Angle Glaucoma – A Meta-analysis with meta-regression
title_full_unstemmed	Triglycerides and Open Angle Glaucoma – A Meta-analysis with meta-regression
title_sort	triglycerides and open angle glaucoma – a meta-analysis with meta-regression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/841e471609f54c44a1cfe4b110f4de86
work_keys_str_mv	AT laurapertl triglyceridesandopenangleglaucomaametaanalysiswithmetaregression AT georgmossbock triglyceridesandopenangleglaucomaametaanalysiswithmetaregression AT andreaswedrich triglyceridesandopenangleglaucomaametaanalysiswithmetaregression AT martinweger triglyceridesandopenangleglaucomaametaanalysiswithmetaregression AT oliverkonigsbrugge triglyceridesandopenangleglaucomaametaanalysiswithmetaregression AT gunthersilbernagel triglyceridesandopenangleglaucomaametaanalysiswithmetaregression AT florianposch triglyceridesandopenangleglaucomaametaanalysiswithmetaregression
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Triglycerides and Open Angle Glaucoma – A Meta-analysis with meta-regression

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