Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation

Renal inflammation and fibrosis are observed in underlying diseases associated with the pathological progression of chronic kidney disease (CKD). The inhibition of renal inflammation and fibrosis is one method to suppress the progression of CKD. Juzentaihoto (TJ-48), a Kampo medicine, effectively re...

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Autores principales:	Satoyasu Ito, Eri Manabe, Yi Dai, Masaharu Ishihara, Takeshi Tsujino
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Chronic kidney disease Fibrosis Inflammation TJ-48 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/841fc600857f446ea16cb732e5607f7b
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spelling	oai:doaj.org-article:841fc600857f446ea16cb732e5607f7b2021-12-04T04:33:21ZJuzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation1347-861310.1016/j.jphs.2021.10.009https://doaj.org/article/841fc600857f446ea16cb732e5607f7b2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1347861321001043https://doaj.org/toc/1347-8613Renal inflammation and fibrosis are observed in underlying diseases associated with the pathological progression of chronic kidney disease (CKD). The inhibition of renal inflammation and fibrosis is one method to suppress the progression of CKD. Juzentaihoto (TJ-48), a Kampo medicine, effectively relieves chronic wasting diseases and fatigue and has been reported to decrease inflammation. In this study, we investigated whether TJ-48 has a renal protective effect and its underlying mechanism in mice with adenine-induced CKD. BALB/c mice were divided into four groups for examination: (1) control, (2) dietary restriction, (3) adenine, and (4) adenine + TJ-48. Biochemical and histological analyses, gene expression analysis, and complete blood counts were performed. TJ-48 treatment decreased tubular damage and fibrosis. TJ-48 also decreased creatinine levels exacerbated by adenine, suppressed the mRNA expression of tumor necrosis factor-α, chemokine ligand 2, transforming growth factor-β, and kidney injury molecule-1, and decreased the neutrophil/lymphocyte ratio increased by adenine. TJ-48 exerts a renoprotective effect possibly via the suppression of fibrosis and inflammation.Satoyasu ItoEri ManabeYi DaiMasaharu IshiharaTakeshi TsujinoElsevierarticleChronic kidney diseaseFibrosisInflammationTJ-48Therapeutics. PharmacologyRM1-950ENJournal of Pharmacological Sciences, Vol 148, Iss 1, Pp 172-178 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic kidney disease Fibrosis Inflammation TJ-48 Therapeutics. Pharmacology RM1-950
spellingShingle	Chronic kidney disease Fibrosis Inflammation TJ-48 Therapeutics. Pharmacology RM1-950 Satoyasu Ito Eri Manabe Yi Dai Masaharu Ishihara Takeshi Tsujino Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation
description	Renal inflammation and fibrosis are observed in underlying diseases associated with the pathological progression of chronic kidney disease (CKD). The inhibition of renal inflammation and fibrosis is one method to suppress the progression of CKD. Juzentaihoto (TJ-48), a Kampo medicine, effectively relieves chronic wasting diseases and fatigue and has been reported to decrease inflammation. In this study, we investigated whether TJ-48 has a renal protective effect and its underlying mechanism in mice with adenine-induced CKD. BALB/c mice were divided into four groups for examination: (1) control, (2) dietary restriction, (3) adenine, and (4) adenine + TJ-48. Biochemical and histological analyses, gene expression analysis, and complete blood counts were performed. TJ-48 treatment decreased tubular damage and fibrosis. TJ-48 also decreased creatinine levels exacerbated by adenine, suppressed the mRNA expression of tumor necrosis factor-α, chemokine ligand 2, transforming growth factor-β, and kidney injury molecule-1, and decreased the neutrophil/lymphocyte ratio increased by adenine. TJ-48 exerts a renoprotective effect possibly via the suppression of fibrosis and inflammation.
format	article
author	Satoyasu Ito Eri Manabe Yi Dai Masaharu Ishihara Takeshi Tsujino
author_facet	Satoyasu Ito Eri Manabe Yi Dai Masaharu Ishihara Takeshi Tsujino
author_sort	Satoyasu Ito
title	Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation
title_short	Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation
title_full	Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation
title_fullStr	Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation
title_full_unstemmed	Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation
title_sort	juzentaihoto improves adenine-induced chronic renal failure in balb/c mice via suppression of renal fibrosis and inflammation
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/841fc600857f446ea16cb732e5607f7b
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Juzentaihoto improves adenine-induced chronic renal failure in BALB/c mice via suppression of renal fibrosis and inflammation

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